carboquone
- CAS No.
- 24279-91-2
- Chemical Name:
- carboquone
- Synonyms
- DK340000;Esquinon;arbamate;Esquinone;NSC 134679;carboquone;Carbazylquinone;Carbazilquinone;carboquone USP/EP/BP;SHHKQEUPHAENFK-UHFFFAOYSA-N
- CBNumber:
- CB4875147
- Molecular Formula:
- C15H19N3O5
- Molecular Weight:
- 321.33
- MDL Number:
- MOL File:
- 24279-91-2.mol
| Melting point | 202° (dec) |
|---|---|
| Boiling point | 460.09°C (rough estimate) |
| Density | 1.1990 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| pka | 13.14±0.50(Predicted) |
| color | Red to reddish-brown crystals |
| FDA UNII | 1CB0HBT12C |
| ATC code | L01AC03 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in male mice, male rats (mg/kg): 6.09, 3.88 i.v.; 3.84, 3.16 i.p.; 30.8, 28.0 orally (Masuda, Suzuki) |
|---|
carboquone Chemical Properties, Uses, Production
Originator
Esquinon,Sankyo,Japan,1974
Definition
ChEBI: Carboquone is an organic molecular entity.
Manufacturing Process
In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1- methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution was cooled. To the cooled solution was added 0.5 ml of aziridine and then the resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4 days. Thereafter, the crystalline substance which precipitated in situ was recovered by filtration and washed with ethanol to give 50 mg of the desired product as red crystals melting at 200°C (with decomposition).
Therapeutic Function
Antineoplastic
Safety Profile
A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx.
