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pipazetate hydrochloride

CAS No.
6056-11-7
Chemical Name:
pipazetate hydrochloride
Synonyms
Selgon;Selvjgon;Lenopect;Selvigon;Pipazetate HCl;Theratuss Hydrochloride;pipazetate hydrochloride;Pipazethate hydrochloride;FEUBUXUFKHXRKO-UHFFFAOYSA-N;Pipazethate Monohydrochloride
CBNumber:
CB4875480
Molecular Formula:
C21H25N3O3S.ClH
Molecular Weight:
435.973
MDL Number:
MOL File:
6056-11-7.mol
Last updated:2023-05-04 15:16:52

pipazetate hydrochloride Properties

Melting point 160-161°
FDA UNII 757GN3W2CZ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362
Toxicity LD50 orally in rats: 560 mg/kg (Schuler)

pipazetate hydrochloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P475700 PipazetateHydrochloride 6056-11-7 10mg $165 2021-12-16 Buy
Usbiological 019745 Pipazetate Hydrochloride 6056-11-7 10mg $460 2021-12-16 Buy
Medical Isotopes, Inc. 52790 PipazetateHCl 6056-11-7 10mg $650 2021-12-16 Buy
American Custom Chemicals Corporation API0016766 PIPAZETHATE HYDROCHLORIDE 95.00% 6056-11-7 10MG $329.7 2021-12-16 Buy
Product number Packaging Price Buy
P475700 10mg $165 Buy
019745 10mg $460 Buy
52790 10mg $650 Buy
API0016766 10MG $329.7 Buy

pipazetate hydrochloride Chemical Properties,Uses,Production

Originator

Theratuss, Squibb ,US ,1962

Uses

Pipazetate Hydrochloride, a pyridobenzothiazine derivative an antiarrhythmic characteristics. Pipazetate is used as a cough supressant.

Manufacturing Process

8.5 parts of 1-azaphenothiazine carboxylic acid chloride and 14 parts of piperidino-ethoxyethanol were introduced into 100 parts of chlorobenzene and the mixture boiled under reflux for 5 minutes. After cooling off the precipitated hydrochloride salt of piperidino-ethoxyethanol was filtered off on a suction filter. Water was added to the filtrate and the pH thereof adjusted to 5 to 6 with dilute HCl. The aqueous phase was then removed, a caustic soda solution added thereto and then extracted with ether. The ethyl extract was washed with water, then dried with potash and the ether distilled off. 9.4 parts of the piperidino-ethoxy-ethyl ester of 1-azaphenothiazine carboxylic acid were obtained. This product was dissolved in 20 parts of isopropanol and the solution neutralized with isopropanolic HCl. The monohydrochloride which precipitated out after recrystallization from isopropanol had a melting point of 160°C to 161°C.

Therapeutic Function

Antitussive

pipazetate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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pipazetate hydrochloride Pipazetate HCl 10H-Pyrido[3,2-b][1,4]benzothiazine-10-carboxylicacid, 2-[2-(1-piperidinyl)ethoxy]ethyl ester, hydrochloride (1:1) Pipazethate hydrochloride Selvigon 10H-Pyrido[3,2-b][1,4]benzothiazine-10-carboxylic Acid 2-(2-Piperidinoethoxy)ethyl Ester Hydrochloride 2-(2-Piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate Hydrochloride Lenopect Pipazethate Monohydrochloride Selgon Selvjgon Theratuss Hydrochloride FEUBUXUFKHXRKO-UHFFFAOYSA-N Pipazetate HCl (Pipazethate HCl) 6056-11-7 C21H26ClN3O3S Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals