6,7-dimethoxyphthalide
- CAS No.
- 569-31-3
- Chemical Name:
- 6,7-dimethoxyphthalide
- Synonyms
- Opianyl;Meconine;NSC 35547;Meconic lactone;6,7-dimethoxyphthalide;Meconin, 10 mM in DMSO;Noscapine Impurity 4(Meconine);Meconin (1.0 mg/mL in Chloroform);6,7-dimethoxy-3H-2-benzofuran-1-one;6,7-DiMethoxy-3H-1-isobenzofuranone
- CBNumber:
- CB4883065
- Molecular Formula:
- C10H10O4
- Molecular Weight:
- 194.184
- MDL Number:
- MFCD00219354
- MOL File:
- 569-31-3.mol
- MSDS File:
- SDS
| Melting point | 103℃ |
|---|---|
| Boiling point | 290.62°C (rough estimate) |
| Density | 1.2534 (rough estimate) |
| refractive index | 1.5430 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| Water Solubility | 2.5g/L(25 ºC) |
| FDA UNII | MK5R222CG0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
6,7-dimethoxyphthalide price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9001140 | Meconin ≥95% | 569-31-3 | 5mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 9001140 | Meconin ≥95% | 569-31-3 | 10mg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 9001140 | Meconin ≥95% | 569-31-3 | 50mg | $515 | 2026-04-30 | Buy |
| TRC | TRC-M202900-5MG | Meconin | 569-31-3 | 5mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-M202900-25MG | Meconin | 569-31-3 | 25mg | $314 | 2026-06-03 | Buy |
6,7-dimethoxyphthalide Chemical Properties, Uses, Production
Synthesis
Compound 7 (91.0 g, 0.5 mol), HCHO solution (81 g, 1.0 mol), HCl (80 g, 0.8 mol) and AcOH (200 g) were heated at 50~60 °C for 24 h to obtain a clear solution, which was then poured into cold water Chemicalbook (1kg). The resulting solid was collected by suction filtration, washed with water (60 g x 3), and dried at 50 °C to give crude cinnamon 8 (95 g) as a tan solid, which was purified by recrystallization from 90% MeOH/H2O (180 g) ) to obtain purified Meconin.
Chemical Properties
White Solid
Uses
A lactone of meconinic acid, extracted from opium. Meconin is a marker for illicit opiate use.
Definition
ChEBI: Meconine is a member of 2-benzofurans.
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 3369, 1987 DOI: 10.1016/S0040-4039(00)95515-1
IC 50
Human Endogenous Metabolite
6,7-dimethoxyphthalide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Anhui Shite Pharmaceutical Technology Co., LTD | 086-21-50829787 13621628489 | sales1@stepuppharm.com | China | 253 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
