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ChemicalBook >> CAS DataBase List >>4,4'-Bis(2-bromoacetyl)biphenyl

4,4'-Bis(2-bromoacetyl)biphenyl

4,4'-Bis(2-bromoacetyl)biphenyl Structure
4,4'-Bis(2-bromoacetyl)biphenyl structure
CAS No.
4072-67-7
Chemical Name:
4,4'-Bis(2-bromoacetyl)biphenyl
Synonyms
1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethane-1-one;Einecs 223-785-3;4,4'-Bis(2-bromoacet;Daclatasvir Intermediate 1;-biphenyl]-4-yl]ethan-1-one;Daclatasvir Intermediates 2;4,4'-bis(bromoacetyl)biphenyl;4,4'-Bis(2-bromoacetyl)biphenyl;4,4'-Bis(2-bromoacetyl)biphenyl(BABP);1,1'-(biphenyl-4,4'-diyl)bis(2-bromoethanone)
CBNumber:
CB4912273
Molecular Formula:
C16H12Br2O2
Molecular Weight:
396.07
MDL Number:
MFCD00017877
MOL File:
4072-67-7.mol
MSDS File:
SDS
Last updated:2026-07-06 17:03:36
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4,4'-Bis(2-bromoacetyl)biphenyl Properties

Melting point 226-227 °C(Solv: benzene (71-43-2))
Boiling point 464.8±30.0 °C(Predicted)
Density 1.622±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance Off-white to light brown Solid
InChI InChI=1S/C16H12Br2O2/c17-9-15(19)13-5-1-11(2-6-13)12-3-7-14(8-4-12)16(20)10-18/h1-8H,9-10H2
InChIKey RTSLQVZQORGDQQ-UHFFFAOYSA-N
SMILES C1(C2=CC=C(C(=O)CBr)C=C2)=CC=C(C(=O)CBr)C=C1
FDA UNII UMK2D77YJA
EPA Substance Registry System Ethanone, 1,1'-[1,1'-biphenyl]-4,4'-diylbis[2-bromo- (4072-67-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
TSCA  TSCA listed
HS Code  29147000

4,4'-Bis(2-bromoacetyl)biphenyl price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix B58594 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone) 95+% 4072-67-7 1g $28 2026-05-06 Buy
Synthonix B58594 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone) 95+% 4072-67-7 5g $32 2026-05-06 Buy
Synthonix B58594 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone) 95+% 4072-67-7 10g $33 2026-05-06 Buy
Synthonix B58594 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone) 95+% 4072-67-7 25g $34 2026-05-06 Buy
Synthonix B58594 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone) 95+% 4072-67-7 100g $136 2026-05-06 Buy
Product number Packaging Price Buy
B58594 1g $28 Buy
B58594 5g $32 Buy
B58594 10g $33 Buy
B58594 25g $34 Buy
B58594 100g $136 Buy

4,4'-Bis(2-bromoacetyl)biphenyl Chemical Properties, Uses, Production

Uses

4,4'-Bis(2-bromoacetyl)biphenyl is an intermediate in laboratory research and development.

Synthesis

Biphenyl

92-52-4

Bromoacetyl bromide

598-21-0

4,4'-Bis(2-bromoacetyl)biphenyl

4072-67-7

To a reaction flask was added 138.8 g (1.04 mol, 2.9 eq.) of aluminum trichloride. 700 ml of dichloromethane was added and the system was cooled to 0-10 °C and stirred. 174.6 g (0.87 mol, 2.4 eq.) of bromoacetyl bromide was slowly added dropwise, controlling the temperature to be maintained at 0 to 10 °C during the dropwise addition. After the dropwise addition, stirring of the reaction mixture was continued for 10 to 30 minutes. Subsequently, 150 ml of dichloromethane solution containing 55.8 g (0.36 mol, 1.0 equiv) of biphenyl was slowly added. After the addition was completed, the reaction mixture was gradually warmed to room temperature with continuous stirring. Next, 200 ml of n-heptane was added to the system, the temperature was raised to reflux, and the reaction was maintained at this temperature for 4 to 5 hours until the alkaline reaction was complete and a large amount of product precipitated. The reaction mixture was continued to be stirred at room temperature for 3 to 5 hours, followed by diafiltration to give the crude product 4,4'-bis(2-bromoacetyl)biphenyl (I). The crude product I was suspended in 500 ml of water and stirred for 1 to 2 hours at room temperature and diafiltrated to give 4,4'-bis(2-bromoacetyl)biphenyl crude oil (II). The crude product II was pulped in 300 ml of dichloromethane, stirred for 1 to 2 hours at room temperature and filtered to give purified 4,4'-bis(2-bromoacetyl)biphenyl. Finally, the product was dried under vacuum at 70 °C to give 121.3 g solid with 99.4% purity and 84.9% yield.

References

[1] Patent: CN108727171, 2018, A. Location in patent: Paragraph 0049-0057
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 1, p. 104 - 107
[3] Journal of the American Pharmaceutical Association (1912-1977), 1954, vol. 43, p. 79,80
[4] Bulletin de la Societe Chimique de France, 1958, p. 1156,1158
[5] Chemical and Pharmaceutical Bulletin, 1971, vol. 19, p. 2262 - 2270

4,4'-Bis(2-bromoacetyl)biphenyl Preparation Products And Raw materials

Raw materials

Biphenyl 4,4'-Diacetylbiphenyl Bromoacetyl bromide Aluminum chloride Dichloromethane

Preparation Products

4,4'-Bis(piperidinoacetyl)biphenyl dihydrobromide

4,4'-Bis(2-bromoacetyl)biphenyl Suppliers

Global Suppliers ( 237)
Supplier Tel Email Country ProdList Advantage
Yantai Xianhua Chemical Technology Co., Ltd (HSBC Shandong Yantai Fine Chemical Co., Ltd.) 18754503080 sunzhulin@xhtechgroup.com China 90 58
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 991 64
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6741 52
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Synches Co., Ltd. 021-53292253 biz@synches.com China 199 64
Changzhou Joyous Chemical Co., Ltd. 0519-85607258 sales@joyouschem.com China 292 60
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 21-33585366 13311639313 sales@shyrchem.com China 807 55
Supplier Advantage
Yantai Xianhua Chemical Technology Co., Ltd (HSBC Shandong Yantai Fine Chemical Co., Ltd.) 58
ChemFuture PharmaTech (Jiangsu) Ltd 65
Energy Chemical 61
Shanghai Boc Chemical Co.,Ltd 64
XiaoGan ShenYuan ChemPharm co,ltd 52
Beijing Isomersyn Technology CO;LTD 57
Synches Co., Ltd. 64
Changzhou Joyous Chemical Co., Ltd. 60
Shanghai T&W Pharmaceutical Co., Ltd. 58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 55

View Latest Price from 4,4'-Bis(2-bromoacetyl)biphenyl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4'-Bis(2-bromoacetyl)biphenyl pictures 2026-09-02 4,4'-Bis(2-bromoacetyl)biphenyl
4072-67-7
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd
4,4'-Bis(2-bromoacetyl)biphenyl pictures 2026-08-07 4,4'-Bis(2-bromoacetyl)biphenyl
4072-67-7
 $20.00-30.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
4,4'-Bis(2-bromoacetyl)biphenyl pictures 2026-07-06 4,4'-Bis(2-bromoacetyl)biphenyl
4072-67-7
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd

4,4'-Bis(2-bromoacetyl)biphenyl Spectrum

4,4'-Bis(2-bromoacetyl)biphenyl(4072-67-7)1HNMR

4072-67-7 (4,4'-Bis(2-bromoacetyl)biphenyl) Related Search:

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1of4

1,1'-[1,1'-biphenyl]-4,4'-diylbis[2-bromoethan-1-one] 1,1'-(1,1'-Biphenyl-4,4'-diyl)bis(2-bromoethanone) Einecs 223-785-3 Ethanone, 1,1'-(1,1'-biphenyl)-4,4'-diylbis(2-bromo- 4,4'-Bis(2-bromoacetyl)biphenyl 2-Bromo-1-[4-[4-(2-bromoacetyl)phenyl]phenyl]ethanone 4,4'-Bis(2-bromoacetyl)biphenyl 1,1'-(1,1'-Biphenyl)-4,4'-diylbis(2-bromoethan-1-one) Daclatasvir Intermediates 2 1,1'-(biphenyl-4,4'-diyl)bis(2-bromoethanone) Daclatasvir Intermediate 1 -biphenyl]-4-yl]ethan-1-one 4,4-Bis-2-bromoacetyl-biphenylQ: What is 4,4-Bis-2-bromoacetyl-biphenyl Q: What is the CAS Number of 4,4-Bis-2-bromoacetyl-biphenyl Q: What is the storage condition of 4,4-Bis-2-bromoacetyl-biphenyl Q: What are the applications of 4,4-Bis-2-bromoacetyl-biphenyl 4,4'-Bis(2-bromoacetyl)biphenyl(BABP) 1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(2-bromoethan-1-one) 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethanone) 4,4'-bis(bromoacetyl)biphenyl 4,4'-Bis(2-bromoacet 1,1'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-bromoethane-1-one 4072-67-7