ChemicalBook >> CAS DataBase List >>6-Ethynyl-4,4-dimethylthiochroman

6-Ethynyl-4,4-dimethylthiochroman

6-Ethynyl-4,4-dimethylthiochroman structure

CAS No.: 118292-06-1

Chemical Name:: 6-Ethynyl-4,4-dimethylthiochroman

Synonyms: Tazarotene Impurity;Tazarotene Impurity 5;Tazarotene Impurity 4;4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN;6-Ethynyl-4,4-dimethyl-thiochroman;4,4-Dimethyl-6-ethynyl-benzothiopyran;6-Ethynyl-4,4-dimethylthiochroman - [E56888];6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene;6-Ethynyl-4,4-dimethyl-2,3-dihydrobenzothiopyran;6-ethynyl-4,4-diMethyl-3,4-dihydro-2H-1-benzothiopyran

CBNumber:: CB4948300

Molecular Formula:: C13H14S

Molecular Weight:: 202.32

MDL Number:: MFCD00902029

MOL File:: 118292-06-1.mol

MSDS File:: SDS

Last updated:2026-05-28 01:57:04

Request For Quotation

6-Ethynyl-4,4-dimethylthiochroman Properties

Melting point	69-72 °C
Boiling point	299 °C
Density	1.09
Flash point	128 °C
storage temp.	2-8°C
Appearance	Light yellow to orange Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

6-Ethynyl-4,4-dimethylthiochroman price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	091202	6-Ethynyl-4,4-dimethylthiochroman	118292-06-1	250.00mg	$189	2026-05-18	Buy
Matrix Scientific	091202	6-Ethynyl-4,4-dimethylthiochroman	118292-06-1	1.00g	$420	2026-05-18	Buy
Matrix Scientific	091202	6-Ethynyl-4,4-dimethylthiochroman	118292-06-1	5.00g	$1183	2026-05-18	Buy
Synthonix	E56888	6-Ethynyl-4,4-dimethylthiochroman 98%	118292-06-1	100mg	$44	2026-05-06	Buy
Synthonix	E56888	6-Ethynyl-4,4-dimethylthiochroman 98%	118292-06-1	250mg	$48	2026-05-06	Buy

Product number	Packaging	Price	Buy
091202	250.00mg	$189	Buy
091202	1.00g	$420	Buy
091202	5.00g	$1183	Buy
E56888	100mg	$44	Buy
E56888	250mg	$48	Buy

6-Ethynyl-4,4-dimethylthiochroman Chemical Properties, Uses, Production

Uses

6-Ethynyl-4,4-dimethylthiochroman is used in preparation of Alkynyl Aryl Iodides via Copper-catalyzed three-component Carboiodination of Arynes.

Synthesis

864841-55-4

118292-06-1

The general procedure for the synthesis of 6-alkynyl-4,4-dimethyldihydrochroman using the compound (CAS: 864841-55-4) as starting material is as follows: Example 4: Preparation of 4,4-dimethyl-6-ethynylthiobenzodihydropyran (2) from compound (8) 1. compound (8) (10.0 g, 45.87 mmol) was dissolved in N,N-dimethylformamide (150 mL) and the reaction system was subsequently cooled to -20°C. 2. Phosphorus trichloride (4.0 mL, 45.87 mmol) was slowly added under stirring and the reaction was continuously stirred for 1 hour. 3. Upon completion of the reaction, the crude product was diluted with ethyl acetate (200 mL) and washed sequentially with saturated sodium chloride solution and deionized water. 4. The organic phase was separated, dried over anhydrous sodium sulfate, filtered and concentrated, and the solvent was removed by vacuum evaporation. 5. The solid obtained was purified by column chromatography with an eluent ratio of hexane/ethyl acetate=9:1, resulting in 7.88 g of the target product (85% yield; oil). Product characterization data: 1H NMR (250 MHz, CDCl3) δ 1.35 (6H, s), 1.95 (2H, m), 3.05 (2H, m), 3.15 (1H, s), 7.13 (1H, d, J = 8.6 Hz), 7.58 (1H, dd, J = 8.6, 2.0 Hz), 7.99 (1H, d, J = 2.0 Hz).

References

[1] Patent: US2006/205950, 2006, A1. Location in patent: Page/Page column 4
[2] Patent: EP1700855, 2006, A1. Location in patent: Page/Page column 6

6-Ethynyl-4,4-dimethylthiochroman Preparation Products And Raw materials

Raw materials

864841-55-4 2H-1-Benzothiopyran, 6-(1,1-dichloroethyl)-3,4-dihydro-4,4-dimethyl-

Preparation Products

Tazarotene

6-Ethynyl-4,4-dimethylthiochroman Suppliers

Global Suppliers ( 141)

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Zhongxin Chemtech Co., Ltd.	022-66880623	sales@tjzxchem.com	China	612	60
Wuhan EnTai Technology Development Co,.Ltd	86-27-82330560	2536851935@qq.com	China	346	69
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Suzhou Zehou Biotechnology Co. , Ltd.	0512-68716880 19984816880	sales@growingchem.com	China	229	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6741	52
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
China Langchem Inc.	0086-21-58956006		China	7798	57

Supplier	Advantage
Tianjin Zhongxin Chemtech Co., Ltd.	60
Wuhan EnTai Technology Development Co,.Ltd	69
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Suzhou Zehou Biotechnology Co. , Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
XiaoGan ShenYuan ChemPharm co,ltd	52
Syntechem Co.,Ltd	57
China Langchem Inc.	57

View Latest Price from 6-Ethynyl-4,4-dimethylthiochroman manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-12	6-Ethynyl-4,4-dimethylthiochroman 118292-06-1		1kg	99%min	1 tons	Hangzhou Verychem Science And Technology Co.Ltd
2025-04-04	6-Ethynyl-4,4-dimethylthiochroman 118292-06-1		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	6-Ethynyl-4,4-dimethylthiochroman 118292-06-1	$1.00	1kg	99%		Career Henan Chemical Co

6-Ethynyl-4,4-dimethylthiochroman
118292-06-1
99%min
Hangzhou Verychem Science And Technology Co.Ltd

6-Ethynyl-4,4-dimethylthiochroman
118292-06-1
98%
Henan Aochuang Chemical Co.,Ltd.

6-Ethynyl-4,4-dimethylthiochroman
118292-06-1
$1.00
99%
Career Henan Chemical Co

118292-06-1 (6-Ethynyl-4,4-dimethylthiochroman) Related Search:

Dimethyl ether Dimethyl carbonate Dimethyl phthalate Dimethyl fumarate Dimethyl sulfate

Hydrochlorothiazide Dacthal Dimethyl disulfide Ethane N,N-Dimethylformamide

Dimethyl sulfoxide 3-Ethynyltoluene Tazarotene 2-tert-Butylthiophenol 4,4-Dimethyl-thiochroman

6-Ethynyl-4,4-dimethylthiochroman 6-(4,4-Dimethyl-thiochroman-6-ylethynyl)-nicotinic acid

1of4

6-Ethynyl-4,4-dimethyl-thiochroman 4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN 6-Ethynyl-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran 6-ethynyl-4,4-diMethyl-3,4-dihydro-2H-1-benzothiopyran 2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-diMethyl- Tazarotene IMpurity (6-Ethynyl-4,4-DiMethyl ThiochroMan) Tazarotene Impurity 5 6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene Tazarotene Impurity 4 Tazarotene Impurity 4,4-Dimethyl-6-ethynyl-benzothiopyran 6-Ethynyl-4,4-dimethylthiochroman - [E56888] 6-Ethynyl-4,4-dimethyl-2,3-dihydrobenzothiopyran 118292-06-1 14871-23-4 C13H14S Pharmaceutical Intermediates