proMMP9-IN-3c
- CAS No.
- 2138321-18-1
- Chemical Name:
- proMMP9-IN-3c
- Synonyms
- proMMP9-IN-3c;ProMMP-9 inhibitor-3c;Butanamide, N-(4-fluorophenyl)-4-[(3,4,5,6,7,8-hexahydro-4-oxo-2-quinazolinyl)thio]-
- CBNumber:
- CB49633052
- Molecular Formula:
- C18H20FN3O2S
- Molecular Weight:
- 361.43
- MDL Number:
- MOL File:
- 2138321-18-1.mol
- MSDS File:
- SDS
proMMP9-IN-3c Chemical Properties, Uses, Production
Description
ProMMP-9 inhibitor-3c is a potent and specific proMMP-9 inhibitor which disrupts f MMP-9 homodimerization and prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR.
Uses
proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX)[1].
References
[1] Alford VM, et al. Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803. DOI:10.1021/acschembio.7b00758
proMMP9-IN-3c Preparation Products And Raw materials
Raw materials
Preparation Products
proMMP9-IN-3c Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from proMMP9-IN-3c manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | ProMMP-9 inhibitor-3c
2138321-18-1
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- ProMMP-9 inhibitor-3c
2138321-18-1
- $1520.00-2500.00
- TargetMol Chemicals Inc.
