VV116
- CAS No.
- 2647442-33-7
- Chemical Name:
- VV116
- Synonyms
- Mindeudesivir;VV116;Remindevir-d1;VV116, 10 mM in DMSO;5′-Guanylic acid, 2′-O,4′-C-methylene- (ACI);D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-5-d)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) (;(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-5-d)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)
- CBNumber:
- CB49734801
- Molecular Formula:
- C24H30DN5O7
- Molecular Weight:
- 502.54
- MDL Number:
- MOL File:
- 2647442-33-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.375±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
|---|---|
| solubility | DMF: 20 mg/ml; DMSO: 12 mg/ml; Ethanol: Slightly soluble |
| form | A solid |
| pka | 4.110±0.30(predicted) |
| color | White to off-white |
| InChIKey | RVSSLHFYCSUAHY-QXMJNOOVSA-N |
| SMILES | C([C@@]1(C2=CC([2H])=C3C(=NC=NN23)N)O[C@@H]([C@H]([C@H]1OC(=O)C(C)C)OC(=O)C(C)C)COC(=O)C(C)C)#N |
VV116 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37745 | VV116 ≥95% | 2647442-33-7 | 1mg | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 37745 | VV116 ≥95% | 2647442-33-7 | 5mg | $522 | 2026-04-30 | Buy |
| Cayman Chemical | 37745 | VV116 ≥95% | 2647442-33-7 | 10mg | $979 | 2026-04-30 | Buy |
| Cayman Chemical | 37745 | VV116 ≥95% | 2647442-33-7 | 25mg | $2292 | 2026-04-30 | Buy |
| ChemScene | CS-0498192 | Mindeudesivir 98.20% | 2647442-33-7 | 5mg | $303 | 2026-06-04 | Buy |
VV116 Chemical Properties, Uses, Production
Description
VV116, also known as JT001, is an oral drug candidate of nucleoside analog against SARS-CoV-2. VV116 is a deuterated, tri-isobutyrate ester prodrug of the RDV parent nucleoside, and is rapidly metabolized into the parent nucleoside (116-N1) in the body. 116-N1 is intracellularly converted to the nucleoside triphosphate active form, which would interfere with the function of RNA-dependent RNA polymerase of SARS-CoV-2, thus exerting antiviral effects (Fig. 1). VV116 showed potent activity against a panel of SARS-CoV-2 variants (alpha, beta, delta, and omicron) and excellent therapeutic efficacy in the mice model.
Uses
GS-621763-d1 is the deuterium labeled GS-621763 (HY-145119)[1]. GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice[2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Schfer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111. DOI:10.1101/2021.09.13.460111
VV116 Preparation Products And Raw materials
Raw materials
Preparation Products
VV116 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| Shanghai Synmedia Chemical Co., Ltd. | 021-38681880 13817889927 | sales@synmedia-chem.com | China | 249 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| Xishi Chemical (Shanghai) Co., Ltd. | 021-60499358 13661956116 | info@cs-pharm.com | China | 227 | 58 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2505 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 7998 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2961 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1941 | 55 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
