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ChemicalBook >> CAS DataBase List >>Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- Structure
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- structure
CAS No.
2651196-69-7
Chemical Name:
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-
Synonyms
CDK12-IN-4;Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-
CBNumber:
CB49824357
Molecular Formula:
C20H20F2N8O
Molecular Weight:
426.42
MDL Number:
MOL File:
2651196-69-7.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
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Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- Properties

Density 1.73±0.1 g/cm3(Predicted)
pka 8.93±0.30(Predicted)

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- Chemical Properties,Uses,Production

Uses

CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].

IC 50

CDK12: 0.641 μM (IC50); CDK2/cyclinE: >20 μM (IC50); CDK9/cyclinT1: >20 μM (IC50)

References

[1] Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Shanghai Merlot Chemical Co., LTD 15821661757 226174156@qq.com China 476 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29855 58
Supplier Advantage
BOC Sciences 		58
Shanghai Merlot Chemical Co., LTD 58
TargetMol Chemicals Inc. 58
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)- CDK12-IN-4 2651196-69-7 C20H20F2N8O