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L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]-

L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- structure

CAS No.: 264275-77-6

Chemical Name:: L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]-

Synonyms: XVA143;L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]-

CBNumber:: CB49835261

Molecular Formula:: C25H21Cl2N3O8

Molecular Weight:: 562.36

MDL Number:

MOL File:: 264275-77-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:09

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L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- Properties

Boiling point	883.8±65.0 °C(Predicted)
Density	1.550±0.06 g/cm3(Predicted)
pka	3.08±0.10(Predicted)

L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0181864	XVA143 99.94%	264275-77-6	5mg	$508	2026-06-04	Buy
ChemScene	CS-0181864	XVA143 99.94%	264275-77-6	10mg	$812	2026-06-04	Buy
ChemScene	CS-0181864	XVA143 99.94%	264275-77-6	25mg	$1628	2026-06-04	Buy
ChemScene	CS-0181864	XVA143 99.94%	264275-77-6	50mg	$2606	2026-06-04	Buy
ChemScene	CS-0181864	XVA143 99.94%	264275-77-6	100mg	$4171	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0181864	5mg	$508	Buy
CS-0181864	10mg	$812	Buy
CS-0181864	25mg	$1628	Buy
CS-0181864	50mg	$2606	Buy
CS-0181864	100mg	$4171	Buy

L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- Chemical Properties, Uses, Production

Description

XVA143 is a α/β I allosteric inhibitor of the integrin leucocyte function-associated antigen-1 (αLβ2, LFA-1) which plays crucial roles in T cell adhesion, migration and immunological synapse (IS) formation. Consequently, αLβ2 is an important therapeutic target in autoimmunity.

Uses

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1].

References

[1] Azucena Salas, et al. Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity. 2004 Apr;20(4):393-406. DOI:10.1016/s1074-7613(04)00082-2
[2] Mélanie R Tardif, et al. LFA-1 antagonists as agents limiting human immunodeficiency virus type 1 infection and transmission and potentiating the effect of the fusion inhibitor T-20. Antimicrob Agents Chemother. 2009 Nov;53(11):4656-66. DOI:10.1128/AAC.00117-09

L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Younan Technology Co., Ltd	020-82000279 18988941452	YN_research@163.com	China	2984	58
Nantong Hi-Future Biotechnology Co., Ltd	+86-0513; 18051384581	sales@chemhifuture.com	China	3075	58
Shanghai Merlot Chemical Co., LTD	15821661757	226174156@qq.com	China	476	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Guangzhou Younan Technology Co., Ltd	58
Nantong Hi-Future Biotechnology Co., Ltd	58
Shanghai Merlot Chemical Co., LTD	58
TargetMol Chemicals Inc.	58

264275-77-6 (L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]-) Related Search:

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L-Alanine, N-[2,6-dichloro-4-[[[(3-hydroxyphenyl)methyl]amino]carbonyl]benzoyl]-3-[(3,5-dihydroxybenzoyl)amino]- XVA143 264275-77-6 C25H21Cl2N3O8