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4-Chloro-1-butanol

4-Chloro-1-butanol structure

CAS No.: 928-51-8

Chemical Name:: 4-Chloro-1-butanol

Synonyms: 4-chlorobutan-1-ol;4-CHLOROBUTANOL;oro-1-butanoL;4-Chlorolbutanol;4-Choro-1-bytanol;4-chloro-1-butano;4-Chlorbutan-1-ol;4-CHLOROBUTANOL-1;4-CHLORO-1-BUTANOL;4-ChIoro-1-butanoI

CBNumber:: CB5100347

Molecular Formula:: C4H9ClO

Molecular Weight:: 108.57

MDL Number:: MFCD00002967

MOL File:: 928-51-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:29:03

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4-Chloro-1-butanol Properties

Boiling point	84-85 °C/16 mmHg (lit.)
Density	1.088 g/mL at 25 °C (lit.)
refractive index	n20/D 1.453(lit.)
Flash point	97 °F
storage temp.	2-8°C
solubility	Soluble in methanol, chloroform, and dimethyl sufoxide.
form	Liquid
pka	15.01±0.10(Predicted)
color	Clear colorless to light yellow
BRN	1731408
InChI	InChI=1S/C4H9ClO/c5-3-1-2-4-6/h6H,1-4H2
InChIKey	HXHGULXINZUGJX-UHFFFAOYSA-N
SMILES	C(O)CCCCl
CAS DataBase Reference	928-51-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	42EI3I5AY0
NIST Chemistry Reference	4-Chloro-1-butanol(928-51-8)
EPA Substance Registry System	1-Butanol, 4-chloro- (928-51-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07,GHS08

Signal word

Warning

Hazard statements

H226-H290-H302-H315-H319-H335-H351

Precautionary statements

P202-P210-P301+P312-P303+P361+P353-P305+P351+P338-P308+P313

target organs

Respiratory system

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,C,F

Risk Statements

10-22-36/37/38-20/21/22-34-40

Safety Statements

23-24/25-36/37/39-26-16-36/37

RIDADR

UN 2920 8/PG 2

WGK Germany

RTECS

EL1325000

Hazard Note

Harmful

TSCA

TSCA listed

HazardClass

3.2

PackingGroup

III

HS Code

29055910

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Flam. Liq. 3
Met. Corr. 1
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
3		0

4-Chloro-1-butanol price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	278823	4-Chloro-1-butanol technical grade, ~85%	928-51-8	50ml	$132	2026-04-30	Buy
Sigma-Aldrich	278823	4-Chloro-1-butanol technical grade, ~85%	928-51-8	250ml	$567	2026-04-30	Buy
TCI Chemical	C0144	4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran) >85.0%(GC)	928-51-8	25g	$49	2026-04-30	Buy
TCI Chemical	C0144	4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran) >85.0%(GC)	928-51-8	500g	$370	2026-04-30	Buy
TRC	TRC-C367830-50G	4-Chloro-1-butanol (Technical Grade)	928-51-8	50g	$249	2026-06-03	Buy

Product number	Packaging	Price	Buy
278823	50ml	$132	Buy
278823	250ml	$567	Buy
C0144	25g	$49	Buy
C0144	500g	$370	Buy
TRC-C367830-50G	50g	$249	Buy

4-Chloro-1-butanol Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Tetramethylene chlorohydrin is used inorganic synthesis.

Uses

4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Uses

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Definition

ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.

General Description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.

Health Hazard

The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.

Fire Hazard

Flammable; flash point 36°C (97°F); vapor density 3.7 (air = 1); the vapor forms an explosive mixture with air, range is not reported. Fire-extinguishing agent: “alcohol” foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It decomposes to HCl and tetrahydrofuran on heating.

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES and ALCOHOLS.

Waste Disposal

Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.

4-Chloro-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Morpholinobutyl)hydrazine 2-(3-Chloropropyl)-1,3-dioxolane 4-Chloro-butyraldehyde 4-Amino-1-butanol 1-Bromo-4-chlorobutane

1,3-dioxepan-2-one 1-(4-(Pyrrolidin-1-yl)butyl)hydrazine CHEMBRDG-BB 4024933 1-Piperazinebutanol(6CI,7CI,8CI,9CI)

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4-Chloro-1-butanol Suppliers

Global( 420)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Tongling LishidaChem Technology Co., Ltd	19064063435 18606623089	2236291497@qq.com	China	182	58
Chizhou Bluesky Chemical Co., Ltd.	15996451730; 15996451730	719225026@qq.com	China	39	58
Tongling Minlei Trading Co., Ltd.	13955922755	13955922755@163.com	China	208	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Anqing PhiChem Corporation	0556-5209970	salesaq@phichem.com.cn	China	36	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing dtftchem Technology Co., Ltd.	010-60275820 13031183356	elainezt@sina.com	China	1386	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Tongling LishidaChem Technology Co., Ltd	58
Chizhou Bluesky Chemical Co., Ltd.	58
Tongling Minlei Trading Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Anqing PhiChem Corporation	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing dtftchem Technology Co., Ltd.	62
Energy Chemical	61

View Lastest Price from 4-Chloro-1-butanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	4-Chloro-1-butanol 928-51-8	$10.00	1KG	99.%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2025-06-27	4-Chloro-1-butanol 928-51-8	$10.00-30.00	50KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	4-Chloro-1-butanol 928-51-8		1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.

4-Chloro-1-butanol
928-51-8
$10.00
99.%
Hebei Chuanghai Biotechnology Co,.LTD

4-Chloro-1-butanol
928-51-8
$10.00-30.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Chloro-1-butanol
928-51-8
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

4-Chloro-1-butanol Spectrum

4-Chloro-1-butanol(928-51-8)MS 4-Chloro-1-butanol(928-51-8)¹HNMR 4-Chloro-1-butanol(928-51-8)¹³CNMR 4-Chloro-1-butanol(928-51-8)IR1 4-Chloro-1-butanol(928-51-8)Raman

928-51-8(4-Chloro-1-butanol)Related Search:

1-Butanol 2-Methyl-1-propanol 3-Chloro-1,2-propanediol Ethambutol Epichlorohydrin

Sodium tert-butoxide Potassium tert-butoxide tert-Butanol Cyclobutane 4-(4-Piperidyl)-1-butanol

Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) 1-Butanesulfonyl chloride 2-butyl-4-methylpyridine 1-Methylethyl 1-butanesulfonate 4,4'-Dimethyl-2,2'-bipyridyl

L-N-Butylsulfonyl-p-hydroxyphenylalanine Tirofiban hydrochloride monohydrate 1-Butanesulfonic acid methyl ester

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4-CHLORO-1-BUTANOL 4-CHLOROBUTANOL-1 TETRAMETHYLENE CHLOROHYDRIN 1-Butanol, 4-chloro- 4-Chlorbutan-1-ol 4-Chloro-1-butane-ol 4-chloro-1-butano 4-Choro-1-bytanol 4-CHLORO-1-BUTANOL, TECH., CA. 85% 4-Chloro-1-butanol, balance THF andHCl, 85% 4-CHLORO-1-BUTANOL TECH 85% 4-Chloro-1-butanol, tech. 85% 4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran) 4-CHLORO-1-BUTANOL GC ABOUT 90% 4-Chloro-1-butanol, 85%, balance THF and HCl 4-Chloro-1-butanol, balance THF and HCl,90-95% 4-Chloro-1-butanol ,85% [technical grade] 4-Chloro-1-butanol technical grade, ~85% 4-Chloro-1-butanol, 95%, tech. 4-Chloro-1-butanol (Technical Grade) 4 - chloride butyl alcohol 4-Chloro-1-hydroxybutane 4-Chlorobutane-1-ol 4-Chlorolbutanol 4-Chloro-n-butylclcohol Tetramethylenechlorohydrine 4-Chloro-1-butanol, Pract. 4-Chloro-1-butanol, technical, 85% 4-ChIoro-1-butanoI 4-Chloro-1-butanol(containsvaryingamountsofTetrahydrofuran)> oro-1-butanoL 4-CHLOROBUTANOL 4-chlorobutan-1-ol 928-51-8 213-175-5 ClCH24OH C4H9OCl CH2ClCH2CH2CH2OH C4H9ClO HOCH24Cl Organic Building Blocks Oxygen Compounds Building Blocks Alcohols C2 to C6 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides 蠅-Chloroalkanols Alcohols Building Blocks C2 to C6 Chemical Synthesis Organic Building Blocks Oxygen Compounds API Intermediate omega-Chloroalkanols omega-Functional Alkanols, Carboxylic Acids, Amines & Halides bc0001