2-Nitrobenzyl chloride
- CAS No.
- 612-23-7
- Chemical Name:
- 2-Nitrobenzyl chloride
- Synonyms
- 1-(chloromethyl)-2-nitrobenzene;Benzene, 1-(chloromethyl)-2-nitro-;AKOS BBS-00004020;O-NITROBENZYL CHLORIDE;2-Nitrobenzyl chloride;A-CHLORO-O-NITROTOLUENE;α-chloro-2-nitrotoluene;à-chloro-2-nitrotoluene;2-NitrobenzylChloride98%;2-NitrobenzylChloride>
- CBNumber:
- CB5101344
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00007185
- MOL File:
- 612-23-7.mol
- MSDS File:
- SDS
| Melting point | 46-48 °C (lit.) |
|---|---|
| Boiling point | 127-133 °C/10 mmHg (lit.) |
| Density | 1,556 g/cm3 |
| refractive index | 1.5557 (estimate) |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | ethanol: soluble98% |
| form | Crystals, Crystalline Powder or Chunks |
| color | Yellow to tan |
| Water Solubility | Soluble in acetone, alcohol benzene, diethyl ether, and ethanol (98%). Insoluble in water. |
| BRN | 388396 |
| Stability | Stable. Incompatible with bases, moisture, acohols, oxidizing agents, amines. Corrodes steel. |
| InChI | 1S/C7H6ClNO2/c8-5-6-3-1-2-4-7(6)9(10)11/h1-4H,5H2 |
| InChIKey | BXCBUWKTXLWPSB-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccccc1CCl |
| CAS DataBase Reference | 612-23-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | HB8U484NPM |
| EPA Substance Registry System | o-Nitrobenzyl chloride (612-23-7) |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-36 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XS9092000 | |||||||||
| F | 19-21 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Nitrobenzyl chloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41296 | 2-Nitrobenzyl chloride for synthesis | 612-23-7 | 10g | $672 | 2026-04-30 | Buy |
| Sigma-Aldrich | 107336 | 2-Nitrobenzyl chloride 99% | 612-23-7 | 10g | $190 | 2023-06-20 | Buy |
| TCI Chemical | N0182 | 2-Nitrobenzyl Chloride >98.0%(GC)(T) | 612-23-7 | 5g | $74 | 2026-04-30 | Buy |
| TCI Chemical | N0182 | 2-Nitrobenzyl Chloride >98.0%(GC)(T) | 612-23-7 | 25g | $209 | 2026-04-30 | Buy |
| Activate Scientific | AS24998 | 2-Nitrobenzyl Chloride 98% | 612-23-7 | 1g | $37 | 2026-06-04 | Buy |
2-Nitrobenzyl chloride Chemical Properties, Uses, Production
Chemical Properties
liquid
Uses
2-Nitrobenzyl chloride has been used to introduce the photo labile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine. It is used as a pharmaceutical intermediate.
Uses
2-Nitrobenzyl chloride was used in the synthesis of S-(2-nitrobenzyl)cysteine which was inserted into human erythropoietin. 2-Nitrobenzyl chloride was used to prepare 4,4′-dinitrostillbene.
General Description
Pale yellow crystals. Insoluble in water. Is thermally unstable.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic. Lachrymator. Causes irritation on contact. Hazardous decomposition products. Mutagen.
Fire Hazard
2-NITROBENZYL CHLORIDE is combustible.
Biochem/physiol Actions
2-Nitrobenzyl chloride reacts with N-methyldiethanolamine and further reaction of the resulting quaternary diol with thionyl chloride at room temperature yields nitrobenzyl mustard quaternary salts.
2-Nitrobenzyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | 85521272 18932438858 | sales@chemfish.com | China | 7780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29676 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 43514 | 58 |
| Shanghai Baoyang Baoxin Biotechnology Co., LTD | 021-56698539 19921169802 | bxsw_sh@163.com | China | 3913 | 58 |
| Beijing Jingtu Hengsheng Commerce&Trade Co.,Ltd. | 00-13911456598 13911456598 | 13911456598@163.cn | China | 2529 | 58 |
| Nanjing Bic Biotechnology Co., Ltd | 025-58906079 15151970915 | sales@bicbiotech.com | China | 1066 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43392 | 58 |
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