1,6-Naphthyridin-5(6H)-one
- CAS No.
- 23616-31-1
- Chemical Name:
- 1,6-Naphthyridin-5(6H)-one
- Synonyms
- 1,6-Naphthyridin-5(6H);1,6-Naphthyridin-5-one;6H-1,6-naphthyridin-5-one;5-Hydroxy-1,6-naphthyridine;1,6-naphthyridine-5(6H)-one;5,6-dihydro-1,6-naphthyridin-5-one
- CBNumber:
- CB51096397
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD08567947
- MOL File:
- 23616-31-1.mol
- MSDS File:
- SDS
| Melting point | 239-241°C |
|---|---|
| Boiling point | 425.6±45.0 °C(Predicted) |
| Density | 1.267±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 11.18±0.20(Predicted) |
| Appearance | Light green to green Solid |
| InChI | InChI=1S/C8H6N2O/c11-8-6-2-1-4-9-7(6)3-5-10-8/h1-5H,(H,10,11) |
| InChIKey | WTYLPQUOPMMOQW-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(=O)NC=C2)C=CC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
1,6-Naphthyridin-5(6H)-one price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 64909 | 1,6-NAPHTHYRIDIN-5-ONE 97% | 23616-31-1 | 0.25G | $124 | 2026-04-30 | Buy |
| AstaTech | 64909 | 1,6-NAPHTHYRIDIN-5-ONE 97% | 23616-31-1 | 1G | $310 | 2026-04-30 | Buy |
| Apolloscientific | OR318077 | 1,6-Naphthyridin-5(6H)-one 97% | 23616-31-1 | 250mg | $102 | 2026-06-04 | Buy |
| Activate Scientific | AS16006 | 1,6-Naphthyridin-5-one 95% | 23616-31-1 | 1g | $225 | 2026-06-04 | Buy |
| Activate Scientific | AS16006 | 1,6-Naphthyridin-5-one 95% | 23616-31-1 | 5g | $788 | 2026-06-04 | Buy |
1,6-Naphthyridin-5(6H)-one Chemical Properties, Uses, Production
Description
1,6-Naphthyridin-5-one has both pyridinenaphthalene ring and active NH in its molecular structure, which can be used as a potential active functional group for synthesis of new drugs.
Uses
1,6-Naphthyridin-5-one can be used as a pharmaceutical intermediate for pharmaceutical experimental research and pharmaceutical synthesis.
Synthesis
58539-65-4
4637-24-5
23616-31-1
A mixture of 2-methylnicotinamide (13 g, 95.6 mmol, 1 eq.) and N,N-dimethylformamide dimethyl acetal (18.2 mL) was heated at 50 °C for 2 hours. During the second hour of the reaction, all volatiles were removed by distillation under reduced pressure. After cooling the residue to room temperature, it was diluted with 100 mL of anhydrous N,N-dimethylformamide, and then sodium hydride (5 g, 124.3 mmol, 1.3 equiv, 60% oil dispersion; note: vigorous release of hydrogen) was added in batches. The reaction mixture was heated at 80 °C for 2.5 h. Subsequently, the mixture was cooled in an ice bath, 25 mL of 2-propanol was added slowly and allowed to stand at 0-5 °C overnight. The resulting solid was collected and dissolved in 10 mL of hot water. The resulting solution was filtered, the filtrate was cooled in an ice bath, and the pH was adjusted dropwise to 7.0 by adding concentrated hydrochloric acid. after storage at 0-5 °C for 3 h, the precipitated solid was collected, washed with ice-cold water, and dried under vacuum to afford 1,6-naphthalenopyridin-5(6H)-one (3 g, 32% yield).1H NMR (DMSO-d6, 300 MHz): δ 8.90 (s, 1H), δ 8.49 (d, J = 7.6Hz, 1H), 7.51-7.43 (m, 2H), 6.61 (d, J = 7.6Hz, 1H).
References
[1] Journal of Heterocyclic Chemistry, 2006, vol. 43, # 5, p. 1311 - 1317
[2] Patent: US2014/94456, 2014, A1. Location in patent: Paragraph 0619; 0621
[3] Patent: WO2015/153683, 2015, A1. Location in patent: Paragraph 0367
1,6-Naphthyridin-5(6H)-one Preparation Products And Raw materials
1,6-Naphthyridin-5(6H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Yizhi Medical Technology Co., LTD | 13287715206 15508629772 | 2786175817@qq.com | China | 65 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Youd Chemical Technology Co., Ltd. | 021-37910092 15821801668 | cong44@126.com | China | 286 | 58 |
View Latest Price from 1,6-Naphthyridin-5(6H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | 1,6-NAPHTHYRIDIN-5(6H)-ONE
23616-31-1
|
$5.50 | 1KG | 98%-99% | 1kg-100kg | Career Henan Chemical Co |
-
- 1,6-NAPHTHYRIDIN-5(6H)-ONE
23616-31-1
- $5.50
- 98%-99%
- Career Henan Chemical Co
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