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N,N-Dimethylformamide dimethyl acetal

N,N-Dimethylformamide dimethyl acetal Structure
N,N-Dimethylformamide dimethyl acetal structure
CAS No.
4637-24-5
Chemical Name:
N,N-Dimethylformamide dimethyl acetal
Synonyms
DMF-DMA;Dimethoxy-N,N-dimethylmethanamine;1,1-dimethoxy-n,n-dimethyl-methanamin;(Dimethylamino)dimethoxymethane;DMF-DIMETHYLACETAL;1,1-DIMETHOXYTRIMETHYLAMINE;1,1-DIMETHOXY-N,N-DIMETHYLMETHYLAMINE;N,N-Dimethylformamide dimethyl;DIMETHYLFORMAMIDEDIMETHYLACETAL;Dimethoxy(dimethylamino)methane
CBNumber:
CB8178244
Molecular Formula:
C5H13NO2
Molecular Weight:
119.16
MDL Number:
MFCD00008482
MOL File:
4637-24-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:46:40
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N,N-Dimethylformamide dimethyl acetal Properties

Melting point -85°C
Boiling point 102-103 °C/720 mmHg (lit.)
Density 0.897 g/mL at 25 °C (lit.)
vapor pressure 34.5hPa at 20℃
refractive index n20/D 1.396(lit.)
Flash point 45 °F
storage temp. Store below +30°C.
solubility Miscible with most organic solvents.
form Solid
pka 5.00±0.50(Predicted)
color White to off-white
PH 7 (H2O)
explosive limit 1.3-17.7%(V)
Water Solubility hydrolysis
Sensitive Moisture Sensitive
BRN 506020
InChI 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
InChIKey ZSXGLVDWWRXATF-UHFFFAOYSA-N
SMILES COC(OC)N(C)C
LogP 0.750 (est)
CAS DataBase Reference 4637-24-5(CAS DataBase Reference)
FDA UNII DF7CTT5QPH
NIST Chemistry Reference Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
EPA Substance Registry System Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)
UNSPSC Code 12352302
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Corrosion (GHS05)Exclamation Mark (GHS07)
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H225-H317-H318-H332
Precautionary statements  P210-P280-P302+P352-P304+P340+P312-P305+P351+P338+P310
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xn,Xi
Risk Statements  11-22-36/37/38-36/38-20-20/21/22-10-52
Safety Statements  16-26-36/37-36/37/39-33-29-7/9
RIDADR  UN 3271 3/PG 2
WGK Germany  1
F  21
Autoignition Temperature 155 °C
TSCA  TSCA listed
HazardClass  3
PackingGroup  II
HS Code  29225000
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Inhalation
Eye Dam. 1
Flam. Liq. 2
Skin Sens. 1
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
REACH Registrations Active
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
3 1

N,N-Dimethylformamide dimethyl acetal price More Price(90)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 140732 N,N-Dimethylformamide dimethyl acetal technical grade, 94% 4637-24-5 25ml $64.7 2026-04-30 Buy
Sigma-Aldrich 140732 N,N-Dimethylformamide dimethyl acetal technical grade, 94% 4637-24-5 2.5l $1430 2026-04-30 Buy
Sigma-Aldrich 8.03068 N,N-Dimethylformamide dimethyl acetal for synthesis 4637-24-5 25mL $56.8 2025-07-31 Buy
Sigma-Aldrich 8.03068 N,N-Dimethylformamide dimethyl acetal for synthesis 4637-24-5 1mL $34.2 2024-03-01 Buy
Sigma-Aldrich 8.03068 N,N-Dimethylformamide dimethyl acetal for synthesis 4637-24-5 100mL $163 2024-03-01 Buy
Product number Packaging Price Buy
140732 25ml $64.7 Buy
140732 2.5l $1430 Buy
8.03068 25mL $56.8 Buy
8.03068 1mL $34.2 Buy
8.03068 100mL $163 Buy

N,N-Dimethylformamide dimethyl acetal Chemical Properties, Uses, Production

Chemical Properties

clear colourless liquid

Uses

1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.

Uses

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Uses

Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highly flammable

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

Synthesis

Sodium Methoxide

124-41-4

N,N-Dimethylformamide

68-12-2

N,N-Dimethylformamide dimethyl acetal

4637-24-5

A method for synthesizing N,N-dimethylformamide dimethyl acetal, comprising the steps of (1) heating N,N-dimethylformamide to 70°C, mixing with dimethyl sulfate in a molar ratio of 1:1 and reacting for 4 hours after the end of dropwise addition to obtain the imine complex, and then cooling to room temperature; (2) adding solid sodium methanol to 200 solvent oil, dispersing it by ultrasonication, adjusting the temperature to 25 ℃ and maintained, dropwise addition of the imine complex, the reaction for 2 hours and then filtered, the filtrate often pressure fractionation, collection of 105-108 ℃ fraction, to obtain N,N-dimethylformamide dimethyl acetal, the yield was 75.3%, purity of 97%; wherein the molar ratio of sodium methanol to the imine complex is 1:1. The synthesis of the N,N-dimethylformamide dimethyl acetal of Example 6 is the same as that of Example 2, the The difference is that the organic solvent of this embodiment is a mixed solvent oil: D40 solvent oil, D60 solvent oil and 260 solvent oil, with a volume ratio of 2:1:1, to obtain N,N-dimethylformamide dimethyl acetal with a yield of 85.4% and a purity of 97%.

References

[1] Patent: CN106083611, 2016, A. Location in patent: Paragraph 0034-0037; 0048-0049

N,N-Dimethylformamide dimethyl acetal synthesis

124-40-3
149-73-5
4637-24-5
Synthesis of N,N-Dimethylformamide dimethyl acetal from Dimethylamine and Trimethoxymethane

N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials

Raw materials

MethanaMiniuM, MethoxydiMethyl-, Methyl sulfate (1:1) Sodium Methoxide N,N-Dimethylformamide

Preparation Products

(5-(Trifluoromethyl)-1-methyl-1H-pyrazol-4-yl)methanamine (1-tert-Butyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanol 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 5-Methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (5-(Trifluoromethyl)-1-phenyl-1H-pyrazol-4-yl)methanol
1-Phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 1-tert-Butyl 6-methyl 3-formyl-1H-indole-1,6-dicarboxylate Ethyl 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylate 3-Bromochromone 5-(Trifluoromethyl)-1-phenyl-1H-pyrazole-4-carbonitrile
5-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride Methyl 4-amino-6-indolecarboxylate Indole-6-carboxaldehyde Ethyl 1-(tert-butyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 1-Phenyl-5-(trifluoromethyl)pyrazole-4-carbonyl chloride
(1-tert-Butyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanamine Ethyl 2-methyl-3-(trifluoromethyl)pyrazole-4-carboxylate 7-Hydroxyindole 6-Hydroxymethylindole Ethyl 2-phenyl-3-(trifluoromethyl)pyrazole-4-carboxylate
5-(Trifluoromethyl)-1-methyl-1H-pyrazol-4-amine (5-(Trifluoromethyl)-1-phenyl-1H-pyrazol-4-yl)methanamine 3-Nitrobenzo[b]furan-5-ol Ethyl 5-methyl-1-phenyl-1H-pyrazole-4-carboxylate 5-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carbonitrile
3-Nitroisonicotinaldehyde (5-Methyl-1-phenyl-1H-pyrazol-4-yl)methanol 2-Amino-4-methyl-pyrimidine-5-carboxylic acid [1-(4-Fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol 1-Methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
1-tert-Butyl-5-(trifluoromethyl)-1H-pyrazol-4-amine (5-(Trifluoromethyl)-1-methyl-1H-pyrazol-4-yl)methanol 4-(Pyridin-3-yl)pyrimidin-2-amine 1-tert-Butyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonitrile Indole-7-carboxaldehyde
4-Aminomethyl-1-methylpyrazole 5-Hydroxyindole Indole-6-carboxylic acid 5-(Trifluoromethyl)-1-phenyl-1H-pyrazole-4-carboxamide 5-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide

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N,N-Dimethylformamide dimethyl acetal Suppliers

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Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 15995069468 15995069468 3398435160@qq.com China 300 58
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Nanjing Dilu Pharmaceutical Co., Ltd 18014482516 18014482516 977144864@qq.com China 424 58
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Nanjing Hike Biological Technology.,ltd 58
Nanjing Dilu Pharmaceutical Co., Ltd 58
Changzhou DongChen Pharmaceutical Co., Ltd. 55
Changzhou Baokang Pharmaceutical & Chemical Co.,Ltd. 60
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Zhongxin Chenshi (Wuhan) Technology Co., Ltd 58
Shanghai Taijilin Industrial Co., Ltd. 58
changzhoubaotuobiochemical&pharm、LTD. 58
Nanjing Yihua Biotechnology Co., Ltd 58

Related articles

Related Questions

Ask a question
Q:What is N,N-dimethylformamide dimethyl acetal used for?STAR - Apr 17,2026
A:N,N-Dimethylformamide dimethyl acetal (DMFDMA), also called 1,1-dimethoxy-N,N-dimethylmethanamine, is a colorless liquid with rancid odour. The chemical structure of DMFDMA presents two important sites, a partially positive carbon that acts as an electrophile in condensation reactions and a partially negative nitrogen that acts as a nucleophile. Because of its structure, DMFDMA reacts with many different organic groups and can be a versatile reagent used in gas chromatography, as a protecting group and as a C1 synthon, especially in the construction of heterocycles.

View Latest Price from N,N-Dimethylformamide dimethyl acetal manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N-Dimethylformamide dimethyl acetal pictures 2026-09-15 N,N-Dimethylformamide dimethyl acetal
4637-24-5
 0.99 RongNa Biotechnology Co.,Ltd
N,N-dimethyl for mamide dimethyl acctel pictures 2026-09-15 N,N-dimethyl for mamide dimethyl acctel
4637-24-5
 $10.00 1KG 99 1000tons Hubei Deli Pharmaceutical Technology Co., Ltd.
N,N-Dimethylformamide dimethyl acetal pictures 2026-06-30 N,N-Dimethylformamide dimethyl acetal
4637-24-5
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

N,N-Dimethylformamide dimethyl acetal Spectrum

N,N-Dimethylformamide dimethyl acetal(4637-24-5)1HNMRN,N-Dimethylformamide dimethyl acetal(4637-24-5)IR1N,N-Dimethylformamide dimethyl acetal(4637-24-5)Raman

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N-(Dimethoxymethyl)dimethylamine N,N-Dimethylfirmanmidedimethylacetal N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine) N,N-Dimethylformamide dimethyl acetal, ca 97% Methanamine, 1,1-dimethoxy-N,N-dimethyl- esterate m n,n-dimethylformamide dimethyl acetal solution N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL (DMF-DMA) 1,1-Dimethoxytrimethylamin N,N -DIMETHYL FORMAMIDE DIMETHYL ACETYL N,N'-Dimethylformanimide dimethyl acetal N,N-Dimethylformamide Dimethyl Acetal [for Esterification] (0.5ml*10) (Dimethylamino)formaldehyde Dimethoxy-N,N-dimethylmethylamine N,N-Dimethylformamide dimethyl acetal ,95% (Dimethylamino)formaldehyde dimethyl acetal Dimethyl(dimethoxymethyl)amine Dimethylaminomethanal dimethyl acetal N,N-Dimethyl-α,α-dimethoxymethanamine N,N-Dimethylformamide Dimethyl Acetal [for Esterification] 1,1-Dimethoxy-N,N-dimethylmethylamine, 1,1-Dimethoxytrimethylamine N,N-Dimethylformamide dim Trimethylamine, 1,1-dimethoxy- N,N-DIMETHYLDIMETHOXYMETHYLAMINE N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL N-DIMETHOXYMETHYL-N,N-DIMETHYLAMINE DIMETHYLFORMAMIDEDIMETHYLACETAL DMF-DIMETHYLACETAL AURORA KA-683 METHYL-8 REAGENT METHYL-8(R) REAGENT METHYL-8 DMFDMA (DMFA) 1,1-DIMETHOXYTRIMETHYLAMINE dimethylformamidediemthylacetal N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, 9 4% N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, D ERIVATIZATION GRADE DMFDMA [N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL] DmfDmaAcetal N,N-Dimethylformamide dimethyl acetal, 97+% N,N-dimethyl for mamide dimethyl acctel DMFDMA [N N-DiMethylforMaMide diMethyl acetal] N,N-DiMethylforMaMide diMethylacetal(DMFDA) N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 100GR N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 25GR N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 500GR N,N-Dimethylformamide dimethyl acetal, ca. 97% N,N-Dimethylformamide Dimethyl Acetal￡¨DMADMF￡ N,N-DiMethylforMaMide diMethyl acetal, ca. 97%, AcroSeal N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL FO (Dimethoxymethyl)dimethylamine, 1,1-Dimethoxy-N,N-dimethylmethylamine N,N-two DMFtwoMethylal N,N-DiMethylforMaMide diMethyl acetal technical grade, 94% DiMethylfirManMidediMethylacetal(DMFDMA) N,N-Dimethylformamide dimethyl acetal Leflunomide Impurity 5 formamide dimethyL