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2-Methoxy-4-trifluoromethyl-pyridine

2-Methoxy-4-trifluoromethyl-pyridine Structure
2-Methoxy-4-trifluoromethyl-pyridine structure
CAS No.
219715-34-1
Chemical Name:
2-Methoxy-4-trifluoromethyl-pyridine
Synonyms
2-Methoxy-4-trifluoromethyl-pyridine;Pyridine,2-methoxy-4-(trifluoromethyl)-;2-Methoxy-4-trifluoromethyl-pyridine ISO 9001：2015 REACH
CBNumber:
CB51113179
Molecular Formula:
C7H6F3NO
Molecular Weight:
177.12
MDL Number:
MFCD00096939
MOL File:
219715-34-1.mol
MSDS File:
SDS
Last updated:2026-05-12 09:11:21
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2-Methoxy-4-trifluoromethyl-pyridine Properties

Boiling point 172.9±40.0 °C(Predicted)
Density 1.263±0.06 g/cm3(Predicted)
vapor pressure 7.398-7.399hPa at 25℃
storage temp. Sealed in dry,Room Temperature
pka 1.04±0.10(Predicted)
EPA Substance Registry System Pyridine, 2-methoxy-4-(trifluoromethyl)- (219715-34-1)

SAFETY

Risk and Safety Statements

Signal word  Warning
Hazard statements  H411-H226-H302
Precautionary statements  P264-P270-P301+P312-P330-P501
TSCA  TSCA listed
HS Code  2933399990
REACH Registrations Inactive

2-Methoxy-4-trifluoromethyl-pyridine price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC201198 2-Methoxy-4-(trifluoromethyl)pyridine 98% 219715-34-1 1g $191 2026-06-04 Buy
Apolloscientific PC201198 2-Methoxy-4-(trifluoromethyl)pyridine 98% 219715-34-1 5g $613 2026-06-04 Buy
Activate Scientific AS37844 2-Methoxy-4-(trifluoromethyl)pyridine 98% 219715-34-1 1g $136 2026-06-04 Buy
Activate Scientific AS37844 2-Methoxy-4-(trifluoromethyl)pyridine 98% 219715-34-1 5g $478 2026-06-04 Buy
Matrix Scientific 119913 2-Methoxy-4-(trifluoromethyl)pyridine 219715-34-1 1.00g $324 2026-05-18 Buy
Product number Packaging Price Buy
PC201198 1g $191 Buy
PC201198 5g $613 Buy
AS37844 1g $136 Buy
AS37844 5g $478 Buy
119913 1.00g $324 Buy

2-Methoxy-4-trifluoromethyl-pyridine Chemical Properties,Uses,Production

Uses

2-Methoxy-4-(trifluoromethyl)pyridine

Synthesis

Sodium Methoxide

124-41-4

2-Chloro-4-(trifluoromethyl)pyridine

81565-18-6

2-Methoxy-4-trifluoromethyl-pyridine

219715-34-1

In a dry reaction flask, 2-chloro-4-trifluoromethylpyridine (45.5 g, 0.251 mol) and a 30% mass fraction of sodium methanol solution (135.5 g, 0.753 mol) were added. The mixture was stirred well and then heated to 65 °C and maintained at that temperature for the reaction. The progress of the reaction was monitored by gas chromatography (GC) until complete conversion of the feedstock. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered to remove insoluble material. Subsequently, methanol was recovered by distillation under reduced pressure. Water was added to the residue and extracted with dichloromethane to separate the organic and aqueous phases. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the light yellow liquid product 2-methoxy-4-trifluoromethylpyridine (40.9 g, 92.1% yield).

References

[1] Patent: CN108558744, 2018, A. Location in patent: Paragraph 0052-0055
[2] Patent: EP1559320, 2005, A1. Location in patent: Page/Page column 9

2-Methoxy-4-trifluoromethyl-pyridine Preparation Products And Raw materials

Raw materials

Methanol Sodium Methoxide 2-Chloro-4-(trifluoromethyl)pyridine

Preparation Products

2-Methoxy-4-trifluoromethyl-pyridine Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Hunan HuaTeng Pharmaceutical Co., Ltd., 400-8592883 15367835770 sales@huatengsci.com China 5869 58
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
Zheda Panaco Chemical Engineering Co., Ltd 0571-86770761 zhedapanaco02@zhedachem.com China 100 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Nanijing m&m biotechnology Co. ,Ltd. 025-87782433 18021532344 1345332203@qq.com China 4226 58
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
Suzhou Nuoouman Biological Technology Co., Ltd. 15026866316 180642609@qq.com China 4969 58
ANHUI WITOP BIOTECH CO., LTD +8618071025641 eric@witopchemical.com China 23504 58
Supplier Advantage
Pure Chemistry Scientific Inc. 62
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Hunan HuaTeng Pharmaceutical Co., Ltd., 58
Shanghai Tombiopharma Chemical Co. Ltd. 55
Zheda Panaco Chemical Engineering Co., Ltd 60
Amadis Chemical Company Limited 58
Nanijing m&m biotechnology Co. ,Ltd. 58
Aikon International Limited 58
Suzhou Nuoouman Biological Technology Co., Ltd. 58
ANHUI WITOP BIOTECH CO., LTD 58

View Lastest Price from 2-Methoxy-4-trifluoromethyl-pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methoxy-4-trifluoromethyl-pyridine pictures 2026-08-20 2-Methoxy-4-trifluoromethyl-pyridine
219715-34-1
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Methoxy-4-trifluoromethyl-pyridine pictures 2020-01-09 2-Methoxy-4-trifluoromethyl-pyridine
219715-34-1
 $1.00 1ASSAYS 85.0-99.8% 20tons Career Henan Chemical Co

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2-Methoxy-4-trifluoromethyl-pyridine Pyridine,2-methoxy-4-(trifluoromethyl)- 2-Methoxy-4-trifluoromethyl-pyridine ISO 9001：2015 REACH 219715-34-1 Pyridines