1-Boc-azetidine-2-carboxylic acid methyl ester
- CAS No.
- 255882-72-5
- Chemical Name:
- 1-Boc-azetidine-2-carboxylic acid methyl ester
- Synonyms
- 1-Boc-Azetidine-2-carboxy...;Methyl 1-Boc-azetidine-2-carboxylate;Methyl N-Boc-Azetidine-2-carboxylate;tert-butyl methyl azetidine-1,2-dicarboxylate;1-tert-Butyl-2-methylazetidin-1,2-dicarboxylat;1-TERT-BUTYL METHYL AZETIDINE-1,2-DICARBOXYLATE;O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate;1-O-tert-butyl 2-O-methyl azetidine-1,2-dicarboxylate;O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate - [B0733];1,2-Azetidinedicarboxylicacid, 1-(1,1-dimethylethyl) 2-methy...
- CBNumber:
- CB51116837
- Molecular Formula:
- C10H17NO4
- Molecular Weight:
- 215.25
- MDL Number:
- MFCD06657099
- MOL File:
- 255882-72-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| HS Code | 2933998090 |
1-Boc-azetidine-2-carboxylic acid methyl ester price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 27010 | METHYL N-BOC-AZETIDINE-2-CARBOXYLATE 97% | 255882-72-5 | 1G | $23 | 2026-04-30 | Buy |
| AstaTech | 27010 | METHYL N-BOC-AZETIDINE-2-CARBOXYLATE 97% | 255882-72-5 | 5G | $67 | 2026-04-30 | Buy |
| Apolloscientific | OR317246 | 1-Boc-Azetidine-2-carboxylic acid methyl ester 97% | 255882-72-5 | 5g | $82 | 2026-06-04 | Buy |
| Matrix Scientific | 068936 | O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate | 255882-72-5 | 5.00g | $73 | 2026-05-18 | Buy |
| Matrix Scientific | 068936 | O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate | 255882-72-5 | 10.00g | $119 | 2026-05-18 | Buy |
1-Boc-azetidine-2-carboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
Azacyclic butane-2-carboxylic acid has been used in the preparation of many inhibitors, such as liver fibrosis inhibitors and algal growth inhibitors. Furthermore, azacyclic butane-2-carboxylic acid also has important applications in many asymmetric synthetic fields.
Synthesis
67-56-1
159749-28-7
255882-72-5
Isobutyl chloroformate (8.43 g, 61.7 mmol) was slowly added to a solution of anhydrous THF (20 mL) containing N-Boc-azetidine-2-carboxylic acid (12.42 g, 61.7 mmol) and N-methylmorpholine (6.23 g, 61.7 mmol) under nitrogen protection, and the rate of addition was controlled to maintain a reaction temperature of less than -8 °C. After addition, the reaction mixture was stirred at -8 °C for 1 hour, then brought to room temperature and continued stirring for 3 hours. Methanol (200 mL) was added to the reaction solution and stirred at room temperature for 18 hours. Upon completion of the reaction, the volatile components were removed by distillation under reduced pressure and the residue was partitioned with water and diethyl ether. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the oily product methyl N-Boc-2-azetidinecarboxylate (11.15 g, 84.0% yield). The product was confirmed by NMR hydrogen spectrum (CDCl3): δ 1.43 (s, 9H), 2.20 (m, 1H), 2.50 (m, 1H), 3.78 (s, 3H), 3.90 (m, 1H), 4.00 (m, 1H), 4.60 (m, 1H).
References
[1] Patent: WO2006/100461, 2006, A1. Location in patent: Page/Page column 79
1-Boc-azetidine-2-carboxylic acid methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 993 | 60 |
| Runpharm Technology Limited | 18171398856 2968382473 | service@runpharm.com | China | 716 | 55 |
| shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
| Suzhou Ryan Pharmachem Technology Co.,Ltd | 0512-66585217 13962137180 | sales@ryanchem.com | China | 380 | 55 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
View Lastest Price from 1-Boc-azetidine-2-carboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-16 | 1-Boc-azetidine-2-carboxylic acid methyl ester
255882-72-5
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-02-04 | 1-Boc-azetidine-2-carboxylic acid methyl ester
255882-72-5
|
1KG | 98%; 99% | 1kg; 5kg | Career Henan Chemical Co |
-
- 1-Boc-azetidine-2-carboxylic acid methyl ester
255882-72-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Boc-azetidine-2-carboxylic acid methyl ester
255882-72-5
- $0.01
- 98%; 99%
- Career Henan Chemical Co
