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8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline structure

CAS No.: 100331-89-3

Chemical Name:: 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

Synonyms: 8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one;8-benzyloxy-5-(2-broMoacetyl)-2-(1H)-quinolinone;5-(2-Bromoacetyl)-8-benzyloxy-1H-quinolin-2-one;1-[8-(b;8-Benzyloxy-5;Indacaterol int;Indacaterol Impurity 37;Indacaterol Intermediate 2;Adatero and its intermediates;5-BroMoacetyl-8-benzyloxycarbostyril

CBNumber:: CB51119227

Molecular Formula:: C18H14BrNO3

Molecular Weight:: 372.21

MDL Number:: MFCD07784037

MOL File:: 100331-89-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:14:19

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8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Properties

Melting point	192-194oC
Boiling point	602.6±55.0 °C(Predicted)
Density	1.479±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly)
pka	10.38±0.70(Predicted)
form	Solid
color	White to Pale Beige
Stability	Unstable in DMSO
InChI	InChI=1S/C18H14BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,20,22)
InChIKey	RVHSDLUBNZBRMH-UHFFFAOYSA-N
SMILES	N1C2=C(C(C(CBr)=O)=CC=C2OCC2=CC=CC=C2)C=CC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-B286115-25MG	8-Benzyloxy-5-(2-bromoacetyl)-2(1H)-quinolinone	100331-89-3	25mg	$186	2026-06-03	Buy
TRC	TRC-B286115-10MG	8-Benzyloxy-5-(2-bromoacetyl)-2(1H)-quinolinone	100331-89-3	10mg	$91	2026-06-03	Buy
TRC	TRC-B286115-100MG	8-Benzyloxy-5-(2-bromoacetyl)-2(1H)-quinolinone	100331-89-3	100mg	$339	2026-06-03	Buy
AstaTech	53534	8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE 97%	100331-89-3	5G	$44	2026-04-30	Buy
AstaTech	53534	8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE 97%	100331-89-3	25G	$97	2026-04-30	Buy

Product number	Packaging	Price	Buy
TRC-B286115-25MG	25mg	$186	Buy
TRC-B286115-10MG	10mg	$91	Buy
TRC-B286115-100MG	100mg	$339	Buy
53534	5G	$44	Buy
53534	25G	$97	Buy

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Chemical Properties, Uses, Production

Chemical Properties

Off-white Solid

Uses

8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one can be used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Synthesis

5-Acetyl-8-(phenylmethoxy)-2-quinolinone

93609-84-8

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

100331-89-3

(1) A bromine solution was prepared by dissolving 7.8 g of bromine in 30 mL of dichloromethane. In another reaction flask, 13 g of 5-acetyl-8-benzyloxy-1H-quinolin-2-one and 7.56 g of boron trifluoride ether compound were dissolved in 170 ml of dichloromethane and heated to reflux. Subsequently, the bromine solution was slowly added dropwise to the refluxed solution and the reflux reaction was continued for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to alkaline by adding 10% aqueous potassium carbonate solution and the resulting precipitate was collected by filtration. The resulting crude product was purified by recrystallization from a solvent mixture of chloroform and methanol, resulting in 12.51 g of 5-bromoacetyl-8-benzyloxy-1H-quinolin-2-one as light yellow acicular crystals in 75.7% yield.

References

[1] Patent: US4579854, 1986, A
[2] Patent: WO2012/168349, 2012, A1. Location in patent: Page/Page column 30-31
[3] Patent: WO2012/168359, 2012, A1. Location in patent: Page/Page column 56; 57
[4] Patent: US2013/34504, 2013, A1. Location in patent: Paragraph 0120; 0121; 0122
[5] Patent: US2014/163066, 2014, A1. Location in patent: Paragraph 0209-0211

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Preparation Products And Raw materials

Raw materials

5-Acetyl-8-(phenylmethoxy)-2-quinolinone Potassium carbonate Dichloromethane

Preparation Products

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Suppliers

Global Suppliers ( 231)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Goyic Pharmaceutical & Chemical Co., Ltd.	021-50689757 15618953996	sales@goyic.com	China	310	58
NanJing FineTech Chemical Co., Ltd	025-52078417 17714198479	sales@fine-chemtech.com	China	275	58
Wuhan Mayue Longteng Technology Development Co., Ltd.	132-37125928 15171477138	2428374547@qq.com	China	52	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Shanghai Goyic Pharmaceutical & Chemical Co., Ltd.	58
NanJing FineTech Chemical Co., Ltd	58
Wuhan Mayue Longteng Technology Development Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Adamas Reagent, Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE 100331-89-3	$2.00	1kg	99%	1200KG/M	Jinan Million Pharmaceutical Co., Ltd
2026-08-10	8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline 100331-89-3	$1.00	1kg	99	1111	S&Y Biochem Co.,Ltd
2025-11-19	8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline 100331-89-3		1kg	98%	200KG	Shanghai Joiny Pharmaceutical Co.,LTD

8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE
100331-89-3
$2.00
99%
Jinan Million Pharmaceutical Co., Ltd

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
100331-89-3
$1.00
99
S&Y Biochem Co.,Ltd

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
100331-89-3
$0.00
98%
Shanghai Joiny Pharmaceutical Co.,LTD

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Spectrum

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline(100331-89-3)¹HNMR

100331-89-3 (8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline) Related Search:

6-Bromomethyl-3,4-dihydro-2-methyl-quinazolin-4-one 5-Acetyl-8-(phenylmethoxy)-2-quinolinone Indeno(1,2,3-c,d)pyrene 2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2R)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, rel- Indacaterol Impurity 13 (Mixture of Diastereomers)

Indacaterol interMediate 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride 2(1H)-Quinolinone, 5-[(1S)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 2(1H)-Quinolinone, 5,5'-[[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)imino]bis(1-hydroxy-2,1-ethanediyl)]bis[8-(phenylmethoxy)- (S)-Indacaterol

Indacaterol Impurity 12 5-ForMyl-8-hydroxycarbostyril N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)(phenylmethyl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 2,8-Quinolinediol

(S)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one Indacaterol Impurity 19 2-Aminoindan hydrochloride

1of4

8-Benzyloxy-5 1-[8-(benzyloxy)-2-hydroxyquinolin-5-yl]-2-broMoethan-1-one 5-(2-BroMo-1-oxoethyl)-8-benzyloxy-2(1H)-quinolinone 5-(BroMoacetyl)-8-(phenylMethoxy)-2(1H)-quinolinone 5-BroMoacetyl-8-benzyloxycarbostyril 8-Benzyloxy-5-(2-broMoacetyl)-2-(1h)-quinoline 2(1H)-Quinolinone, 5-(2-bromoacetyl)-8-(phenylmethoxy)- Indacaterol Intermediate 2 8-(Benzyloxy)-5-(broMoacetyl)quinolin-2(1H)-one 1-[8-(b Indacaterol int Adatero and its intermediates 5-(2-Bromoacetyl)-8-benzyloxy-1H-quinolin-2-one 5-(2-bromoacetyl)-8-phenylmethoxy-1H-quinolin-2-one Indacaterol Impurity 37 5-(2-Bromoacetyl)-8-(phenylmethoxy)-2(1H)-quinolinone 8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE Intermediate of 8-benzyloxy-5-bromoacetyl-2-quinolinone indaterol 5-Bromoacetyl-8-benzyloxy-2-quinolone 8-Benzyloxyl-5-(2-bromoacetyl)-2-hydroxyquinoline 8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one 8-benzyloxy-5-(2-broMoacetyl)-2-(1H)-quinolinone 8-benzyloxy-5-(2-bromoacety)-2-(lH)-quinolinone) BHQ_[8-(benzyloxy)-5-(2- bromoacetyl_quinolin-2 (1H)-one] 100331-89-3 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Intermediate of Indacaterol