2,8-Quinolinediol
- CAS No.
- 15450-76-7
- Chemical Name:
- 2,8-Quinolinediol
- Synonyms
- 8-Hydroxy-2-quinolinone;QUINOLINE-2,8-DIOL;Procaterol Impurity;8-HYDROXYCARBOSTYRIL;8-Hydroxycarbostyryl;2,8-DIHYDROXYQUINOLINE;8-Hydroxy-2(1H)-quinolinone;2,8-Dihydroxyquinoline, 8-Hydroxycarbostyril, 8-Hydroxyquinolin-2(1H)-one;8-diol;inedioL
- CBNumber:
- CB8250483
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD00216696
- MOL File:
- 15450-76-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~290 °C (dec.) |
|---|---|
| Boiling point | 403.2±45.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 8.85±0.20(Predicted) |
| color | Dark Reddish Brown |
| λmax | 335nm(EtOH)(lit.) |
| BRN | 472906 |
| InChI | InChI=1S/C9H7NO2/c11-7-3-1-2-6-4-5-8(12)10-9(6)7/h1-5,11H,(H,10,12) |
| InChIKey | ZXZKYYHTWHJHFT-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2O)C=CC1=O |
| CAS DataBase Reference | 15450-76-7(CAS DataBase Reference) |
| FDA UNII | 466PKO4UBM |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933499090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,8-Quinolinediol price More Price(86)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 37640 | 2,8-Quinolinediol ≥99.0% (HPLC) | 15450-76-7 | 1g | $47.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 37640 | 2,8-Quinolinediol ≥99.0% (HPLC) | 15450-76-7 | 5G | $133 | 2023-06-20 | Buy |
| TCI Chemical | D3819 | 2,8-Dihydroxyquinoline >98.0%(GC)(T) | 15450-76-7 | 5g | $53 | 2026-04-30 | Buy |
| TCI Chemical | D3819 | 2,8-Dihydroxyquinoline >98.0%(GC)(T) | 15450-76-7 | 25g | $154 | 2026-04-30 | Buy |
| Cayman Chemical | 36376 | 2,8-Quinolinediol ≥98% | 15450-76-7 | 1g | $32 | 2026-04-30 | Buy |
2,8-Quinolinediol Chemical Properties, Uses, Production
Synthesis
solution of quinoline-8-ol-1-oxide (20 g, 124 mmol) in acetic anhydride (200 mL) was stirred at 90°C for 5 hours. The reaction mixture was then poured into a water/ice mixture (1.5 L) and neutralized by adding conc. aq. The precipitate formed was collected by filtration and washed with water. The crude product was suspended in propanol and purified by adding petroleum ether to give 2-oxo-1,2-dihydroquinoline-8-acetate. 2-oxo-1,2-dihydroquinoline-8-acetate was heated in a concentrated solution. aq. Soaked in hydrochloric acid (200 mL) at 90°C for 4 hours. The reaction mixture was poured into ice water (400 mL), and the precipitate formed was collected by filtration and washed with water. Recrystallization from propane-2-ol/petroleum ether gave the target compound 2,8-quinolinediol (14.1 g, 70%). 
Chemical Properties
Brown Powder
Uses
2,8-Quinolinediol is a substituted quinolinone derivative used in the preparation of pharmaceutical compounds.
Uses
2,8-Quinolinediol is suitable for use as standard in a study to identify the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats by online and off-line LC-MS techniques. It may be used as starting reagent for the preparation of two powerful β2-adrenergic receptor agonists, used for the treatment of asthma:
- Procaterol
- Indacaterol
Definition
ChEBI: Quinoline-2,8-diol is a dihydroxyquinoline. It is a tautomer of an 8-hydroxyquinolin-2(1H)-one.
General Description
2,8-Quinolinediol is a quinolone derivative. It has been reported as metabolite of 8-hydroxyquinoline-N-oxide in rabbits. Synthesis of 2,8-quinolinediol has been reported. It is reported as one of the six possible forms of 8-hydroxycarbostyril. It has been detected as new UV-absorbing compound (UAC) in cow milk and its structure was elucidated using HRMS and by 1H, 13C and 1H ×13C NMR.It is also known as 8-hydroxycarbostyril or 8-hydroxyquinolin-2(1H)-one.
2,8-Quinolinediol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NanJing FineTech Chemical Co., Ltd | 025-52078417 17714198479 | sales@fine-chemtech.com | China | 275 | 58 |
| Nordijia Biopharmaceutical (Suzhou) Co., Ltd. | 15150674956 | dannielee@nordicabio.com | China | 339 | 58 |
| Nanjing Kaitian Chemical Co., Ltd | 15951673915 | 377901895@qq.com | China | 94 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 2,8-Quinolinediol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2,8-Quinolinediol
15450-76-7
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-07-15 | 2,8-Quinolinediol
15450-76-7
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-04-22 | 2,8-Quinolinediol
15450-76-7
|
$29.00 | 99.62% | 10g | TargetMol Chemicals Inc. |
-
- 2,8-Quinolinediol
15450-76-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,8-Quinolinediol
15450-76-7
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,8-Quinolinediol
15450-76-7
- $29.00
- 99.62%
- TargetMol Chemicals Inc.
