D-Pyroglutamic acid tert-butyl ester
- CAS No.
- 205524-46-5
- Chemical Name:
- D-Pyroglutamic acid tert-butyl ester
- Synonyms
- (R)-tert-Butyl 5-oxopyrrolidine-2-carboxylate;idone-5-carboxyL;Glutamic Acid Impurity 21;tert-butyl D-Pyroglutamate;tert-butyl 5-oxo-D-prolinate;5-Oxo-D-proline tert-butyl ester;D-PyroglutaMic acid ter-butyl ester;D-PYROGLUTAMIC ACID TERT-BUTYL ESTER;2-Methyl-2-propanyl 5-oxo-D-prolinate;5-oxo-D-Proline1,1-dimethylethyl ester
- CBNumber:
- CB51119313
- Molecular Formula:
- C9H15NO3
- Molecular Weight:
- 185.22
- MDL Number:
- MFCD09261417
- MOL File:
- 205524-46-5.mol
- MSDS File:
- SDS
| Boiling point | 319℃ |
|---|---|
| Density | 1.099 |
| Flash point | 147℃ |
| storage temp. | 2-8°C |
| pka | 14.65±0.40(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | Consistent with structure |
| InChI | InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)6-4-5-7(11)10-6/h6H,4-5H2,1-3H3,(H,10,11)/t6-/m1/s1 |
| InChIKey | QXGSPAGZWRTTOT-ZCFIWIBFSA-N |
| SMILES | C(OC(C)(C)C)(=O)[C@H]1CCC(=O)N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HS Code | 2933790090 |
D-Pyroglutamic acid tert-butyl ester price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 287633 | D-Pyroglutamic acid tert-butyl ester | 205524-46-5 | 1g | $425 | 2026-06-03 | Buy |
| Usbiological | 287633 | D-Pyroglutamic acid tert-butyl ester | 205524-46-5 | 2g | $588 | 2026-06-03 | Buy |
| Usbiological | 287633 | D-Pyroglutamic acid tert-butyl ester | 205524-46-5 | 5g | $921 | 2026-06-03 | Buy |
| Usbiological | 287633 | D-Pyroglutamic acid tert-butyl ester | 205524-46-5 | 10g | $1204 | 2026-06-03 | Buy |
| Usbiological | 287633 | D-Pyroglutamic acid tert-butyl ester | 205524-46-5 | 25g | $1912 | 2026-06-03 | Buy |
D-Pyroglutamic acid tert-butyl ester Chemical Properties,Uses,Production
Synthesis
540-88-5
4042-36-8
205524-46-5
The general procedure for the synthesis of tert-butyl D-pyroglutamate from tert-butyl acetate and D-(+)-pyroglutamic acid was as follows: (R)-5-oxopyrrolidine-2-carboxylic acid (3.21 g, 24.9 mmol) was dissolved in tert-butyl acetate (100 mL) under argon protection. Subsequently, 60% aqueous perchloric acid (1.5 mL) was slowly added at room temperature. The reaction mixture was stirred at room temperature for 24 hours in an argon atmosphere. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution (50 mL) was added to the mixture to neutralize the reaction solution, followed by extraction with chloroform (3 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by distillation under reduced pressure to afford tert-butyl (R)-5-oxopyrrolidine-2-carboxylate (4.62 g, yield) as a white solid. The physical properties of the product are described below.
References
[1] Chemistry - A European Journal, 2016, vol. 22, # 27, p. 9330 - 9337
[2] Patent: JP6095208, 2017, B2. Location in patent: Paragraph 0036-0038
D-Pyroglutamic acid tert-butyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yurlic Chemical S&T Co.Ltd. | 021-37285141 15618858630 | yancf@yulibiotech.com | China | 170 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ChangShu Haitian Fine Chemicals Co.,Ltd | 13913622609 | 974295387@qq.com | China | 192 | 61 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
View Lastest Price from D-Pyroglutamic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
205524-46-5
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
205524-46-5
- $100.00
- 99%
- Career Henan Chemical Co
