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N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol

N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol structure

CAS No.: 129049-51-0

Chemical Name:: N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol

Synonyms: EMD 52297;N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol;L-threo-Pentonamide, 5-cyclohexyl-2,4,5-trideoxy-4-[[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidyl]amino]-N-[2-methyl-1-[[(2H-tetrazol-2-ylmethyl)amino]carbonyl]butyl]-, [S-(R*,R*)]- (9CI)

CBNumber:: CB51249063

Molecular Formula:: C39H59N11O7

Molecular Weight:: 793.96

MDL Number:

MOL File:: 129049-51-0.mol

Last updated:2025-04-18 09:52:24

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N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol Chemical Properties, Uses, Production

Description

Emd 52297 is a renin inhibitor.

Uses

EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor[1][2].

References

[1] Miriam T Rademaker, et al. Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circ Heart Fail. 2012 Sep 1;5(5):645-52. DOI:10.1161/CIRCHEARTFAILURE.112.967059
[2] Jürgen Maibaum, et al. Renin inhibitors as novel treatments for cardiovascular disease. Expert Opinion on Therapeutic Patents. Volume 13, 2003 - Issue 5.

N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol Preparation Products And Raw materials

Raw materials

Preparation Products

N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

129049-51-0 (N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol) Related Search:

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N-(tert-Butoxycarbonal)-phenylalanyl-histidyl-(4-amino-3-hydroxy-5-cyc lohexyl)-pentacarbonyl-isoleucyl-(2-amidomethyl)tetrazol EMD 52297 L-threo-Pentonamide, 5-cyclohexyl-2,4,5-trideoxy-4-[[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-L-histidyl]amino]-N-[2-methyl-1-[[(2H-tetrazol-2-ylmethyl)amino]carbonyl]butyl]-, [S-(R*,R*)]- (9CI) 129049-51-0 C39H59N11O7