Xanthohumol

Xanthohumol Properties

Melting point	157-159℃
Boiling point	576.5±50.0 °C(Predicted)
Density	1.244
storage temp.	2-8°C
solubility	ethanol: soluble10mg/mL
form	powder
pka	7.59±0.45(Predicted)
color	Yellow
biological source	plant (Humulus lupulus)
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChI	InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
InChIKey	ORXQGKIUCDPEAJ-YRNVUSSQSA-N
SMILES	C(C1=C(OC)C=C(O)C(C/C=C(/C)\C)=C1O)(=O)/C=C/C1=CC=C(O)C=C1
LogP	5.172 (est)
FDA UNII	T4467YT1NT
NCI Drug Dictionary	xanthohumol
UNSPSC Code	85151701
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H317-H400
Precautionary statements	P273-P280
PPE	Eyeshields, Faceshields, Gloves
Hazard Codes	N,Xi
Risk Statements	50/53-43
Safety Statements	60-61-45-22
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	UD5574117
HS Code	29145090
Storage Class	11 - Combustible Solids

Xanthohumol price More Price(92)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	X0379	Xanthohumol from hop (Humulus lupulus) ≥96% (HPLC)	6754-58-1	5mg	$391	2026-04-30	Buy
Sigma-Aldrich	01130595	Xanthohumol primary reference standard	6754-58-1	10mg	$1230	2026-04-30	Buy
TCI Chemical	X0068	Xanthohumol >97.0%(HPLC)	6754-58-1	25mg	$651	2026-04-30	Buy
Cayman Chemical	15399	Xanthohumol ≥98%	6754-58-1	1mg	$28	2026-04-30	Buy
Cayman Chemical	15399	Xanthohumol ≥98%	6754-58-1	5mg	$83	2026-04-30	Buy

Product number	Packaging	Price	Buy
X0379	5mg	$391	Buy
01130595	10mg	$1230	Buy
X0068	25mg	$651	Buy
15399	1mg	$28	Buy
15399	5mg	$83	Buy

Xanthohumol Chemical Properties, Uses, Production

Description

Xanthohumol(XH, 6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II) Impairs prostate cancer cell growth and proliferation Cell permeable.

Chemical Properties

Xanthohumol is a Light yellow to Brown powder to crystal. It can dissolve in ethanol. This compound is a natural prenylated chalcone isolated from the hop plant, H. lupulus. Xanthohumol and its metabolites induce protective detoxification enzymes, at least in part via the nuclear factor erythroid-2-related factor 2 pathway.

Uses

Xanthohumol from hop (Humulus lupulus) has been used:
to treat glioblastoma cells to test its effect on inducing apoptosis
to test its protective effect in renal ischemia/reperfusion (I/R) injury
as a component of Dulbecco′s modified Eagle medium (DMEM) to test its antiviral activity in Huh7.5 cells infected with hepatitis C virus cell culture (HCVcc) system

Definition

ChEBI: Xanthohumol is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells. It has a role as a metabolite, an apoptosis inducer, an antineoplastic agent, an antiviral agent, an EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor and an anti-HIV-1 agent. It is a member of chalcones, a polyphenol and an aromatic ether. It is a conjugate acid of a xanthohumol(1-).

Application

Xanthohumol is the prenylated chalcone isolated from the female inflorescences of the hop plant (Humulus lupulus L.), an ingredient of beer, have long been used in traditional medicine. Xanthohumol is one of the bioactive substances, and has been reported that it has various pharmacological activities, including antioxidant, anti-inflammatory, anti-proliferative, and osteogenic effects.

General Description

Xanthohumol (XN), a prenylated chalcone present in Hop (Humulus lupulus), has been found to possess prominent activities against aging, diabetes, inflammation, microbial infection, and cancer.

Biochem/physiol Actions

Xanthohumol induces apoptosis in glioma cancer by modulating microRNA based network. It exhibits anti-inflammatory property by inhibiting janus kinases (JAKs), signal transducer and activator of transcription proteins (STATs). Xanthohumol elicits antiviral functionality against bovine viral diarrhea virus (BVDV) and anti-hepatitis C virus in vitro. It also induces autophagy and has antiplatelet and neuroprotective effects. Xanthohumol also regulates various metabolic processes including the inhibition of triglyceride formation, atherosclerotic plaque and adipogenesis.

storage

Store at +4°C

References

[1] YUKIKO SASAZAWA. Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein[J]. ACS Chemical Biology, 2012, 7 5: 892-900. DOI:10.1021/cb200492h.
[2] ROBERTA VENè. Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice.[J]. Molecular Medicine, 2012, 18: 1292-1302. DOI:10.2119/molmed.2012.00174.
[3] VIOLETTA KRAJKA-KUNIAK Wanda B D Jarosaw Paluszczak. Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro[J]. Toxicology in Vitro, 2013, 27 1: Pages 149-156. DOI:10.1016/j.tiv.2012.10.008.
[4] BIRGIT M. DIETZ Judy L B. Biological reactive intermediates (BRIs) formed from botanical dietary supplements[J]. Chemico-Biological Interactions, 2011, 192 1: Pages 72-80. DOI:10.1016/j.cbi.2010.10.007.
[5] SOSMITHA GIRISA. Xanthohumol from Hop: Hope for cancer prevention and treatment[J]. IUBMB Life, 2021, 73 8: 1016-1044. DOI:10.1002/iub.2522.

Xanthohumol Preparation Products And Raw materials

Raw materials

Preparation Products

Xanthohumol Suppliers

Global Suppliers ( 333)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Spring & Autumn Biological Engineering Co., Ltd.	17388075642 13815430202	sale02@cqherb.com	China	261	59
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
Stanford Chemicals Company	+1 (949) 468-0555	sales@stanfordchem.com	United States	13	60
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Shanghai Winherb Medical Technology Co., Ltd.	17301719108 13341702378	winherb@126.com	China	1245	58

Supplier	Advantage
Nanjing Spring & Autumn Biological Engineering Co., Ltd.	59
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81
Dalian Meilun Biotech Co., Ltd.	58
Stanford Chemicals Company	60
BioBioPha Co., Ltd.	65
T&W GROUP	58
Chengdu Biopurify Phytochemicals Ltd.	60
Shanghai Winherb Medical Technology Co., Ltd.	58

View Latest Price from Xanthohumol manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-19	Xanthohumol 6754-58-1		0.99		RongNa Biotechnology Co.,Ltd
2026-09-11	XANTHOHUMOL 6754-58-1	1KG	≥98% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2026-09-11	Xanthohumol Hops Extract 6754-58-1	1kg	3%-99% HPLC	1000kg	Changsha Staherb Natural Ingredients Co., Ltd.

Xanthohumol
6754-58-1
0.99
RongNa Biotechnology Co.,Ltd

XANTHOHUMOL
6754-58-1
$0.00
≥98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Xanthohumol Hops Extract
6754-58-1
$0.00
3%-99% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Xanthohumol Spectrum

XANTHOHUMOL(6754-58-1)¹HNMR

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XANTHOHUMOL XANTHOHUMOL, HUMULUS LU PULUS 2',4',4-TRIHYDROXY-6'-METHOXY-3'-PRENYLCHALCONE (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one XanthohuMo Xanthohumol from hop (Humulus lupulus) 1-(2,4-Dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 2-Propen-1-one,1-[2,4-dihydroxy-6-Methoxy-3-(3-Methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-,(2E)- Xanthohumol, >99% Humulus Lupulus Extract Xanthohumol 6754-58-1 HPLC 95% 98% Yellow Powder large stock Xanthohumol 6754-58-1 1-(2,4-Dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl) Xantho Flav-Pure Xantho-Flav 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-but-2-enyl)-phenyl]-3-(4-hydroxy-phenyl)-propenone Hops Flower Extract (Standard) Xanthohumol Standard (E)-1-(2,4-Dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)propenone (E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one Xanthohumol ex. Hop (Humulus Lupulus), 94% Xanthohumol Hops Extract Xanthohumol (6CI, 7CI) Xanthohumol 99.8% Xanthohumol-RM high qualtiy Xanthohumol Xanthohumol, 10 mM in DMSO Xanthohumol from hop (Humulus lupulus) (E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methyl-2-buteneyl)phenyl]-3-(4-hydroxyphenyl)propyleneone prop-2-en-1-one 6754-58-1 Flavaniods standard material,plant extracts SiChem