Methyl 5-fluoropicolinate
- CAS No.
- 107504-07-4
- Chemical Name:
- Methyl 5-fluoropicolinate
- Synonyms
- Methyl 5-fluoropicolinate;Methyl 5-fluoropyridine-2-carboxylate;5-fluoropyridine methyl formate;5-fluoropyridolinate methyl ester;methyl 5-fluoro-2-pyridinecarboxylate;5-fluoro-2-pyridinecarboxylic acid methy;5-Fluoropyridine-2-carboxylic acid methyl ester;5-fluoro-2-pyridinecarboxylic acid methyl ester;2-PYRIDINECARBOXYLIC ACID, 5-FLUORO-, METHYL ESTER;2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
- CBNumber:
- CB51289580
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD11845630
- MOL File:
- 107504-07-4.mol
- MSDS File:
- SDS
| Boiling point | 217.2±20.0 °C(Predicted) |
|---|---|
| Density | 1.243±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -0.73±0.10(Predicted) |
| form | solid |
| color | Off-white |
| InChI | InChI=1S/C7H6FNO2/c1-11-7(10)6-3-2-5(8)4-9-6/h2-4H,1H3 |
| InChIKey | KCMBKUFSDZMQEM-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC=C(F)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302-H315 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 2933399990 |
| REACH Registrations | Inactive |
Methyl 5-fluoropicolinate price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC520639 | Methyl 5-fluoropyridine-2-carboxylate 98% | 107504-07-4 | 1g | $36 | 2026-06-04 | Buy |
| Synthonix | M16415 | Methyl 5-fluoropicolinate 97.0% | 107504-07-4 | 1g | $20 | 2026-05-06 | Buy |
| Synthonix | M16415 | Methyl 5-fluoropicolinate 97.0% | 107504-07-4 | 5g | $60 | 2026-05-06 | Buy |
| Synthonix | M16415 | Methyl 5-fluoropicolinate 97.0% | 107504-07-4 | 10g | $100 | 2026-05-06 | Buy |
| Synthonix | M16415 | Methyl 5-fluoropicolinate 97.0% | 107504-07-4 | 25g | $130 | 2026-05-06 | Buy |
Methyl 5-fluoropicolinate Chemical Properties, Uses, Production
Uses
Methyl 5-fluoropicolinate is a fluoroorganic heterocyclic compound that can be used in the preparation of BTK inhibitors or degradation agents for the treatment of BTK-related diseases such as tumours or autoimmune system disorders.
Synthesis
107504-08-5
67-56-1
107504-07-4
General procedure for the synthesis of methyl 5-fluoropyridinecarboxylate: 5 g of 5-fluoropyridine-2-carboxylic acid was added to 50 mL of methanol and 2.7 mL of thionyl chloride was added slowly and dropwise. The reaction mixture was transferred to a sealed microwave reaction flask and the reaction was stirred at 65 °C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a solvent mixture of dichloromethane and methanol and filtered through a silica gel column. The filtrate was collected and concentrated under reduced pressure to give 5.9 g of the target compound, methyl 5-fluoropyridinecarboxylate. Thin layer chromatography showed an Rf value of 0.77 (Method K). Mass spectrometry analysis showed a molecular ion peak (M + H)+ of 156.
References
[1] Patent: WO2013/79460, 2013, A1. Location in patent: Page/Page column 46
[2] Patent: US2013/137688, 2013, A1. Location in patent: Paragraph 0239; 0240; 0241
[3] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0628; 0630-0632
Methyl 5-fluoropicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Diluo Technology Co., LTD | 19279824758 19526192903 | 15106284752@163.com | China | 174 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
View Latest Price from Methyl 5-fluoropicolinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Methyl 5-fluoro-2-pyridinecarboxylate
107504-07-4
|
$2.20-8.80 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2019-07-06 | 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
107504-07-4
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Methyl 5-fluoro-2-pyridinecarboxylate
107504-07-4
- $2.20-8.80
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI)
107504-07-4
- $1.00
- 99%
- Career Henan Chemical Co
