METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
- CAS No.
- 455-70-9
- Chemical Name:
- METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
- Synonyms
- Methyl5-fluoronicotinate;5-Fluoro-nicotinic acid methyl ester;METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE;Methyl 5-fluoro-3-pyridinecarboxylate;5-fluoro-2-methyl-3-pyridinecarboxylate;5-fluoro-3-pyridinecarboxylic acid methyl ester;5-Fluoropyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 5-fluoro-, methyl ester;3-PYRIDINECARBONYL CHLORIDE, 5-FLUORO-, METHYL ESTER;METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber:
- CB42446725
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD01692049
- MOL File:
- 455-70-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 5-fluoronicotinate | CDS020854 | 100mg | $68.1 |
| Methyl 5-fluoropyridine-3-carboxylate 97% | PC200409 | 1g | $21 |
| Methyl 5-fluoropyridine-3-carboxylate 97% | PC200409 | 5g | $25 |
| Methyl 5-fluoropyridine-3-carboxylate 97% | PC200409 | 25g | $100 |
| Methyl 5-fluoropyridine-3-carboxylate 97% | PC200409 | 100g | $374 |
| Melting point | 48 °C |
|---|---|
| Boiling point | 194.5±25.0 °C(Predicted) |
| Density | 1.243±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | 0.77±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | 1S/C7H6FNO2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,1H3 |
| InChIKey | PGCFLXMMCWKPDU-UHFFFAOYSA-N |
| SMILES | O=C(OC)C1=CN=CC(F)=C1 |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS020854 | Methyl 5-fluoronicotinate | 455-70-9 | 100mg | $68.1 | 2023-06-20 | Buy |
| Apolloscientific | PC200409 | Methyl 5-fluoropyridine-3-carboxylate 97% | 455-70-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC200409 | Methyl 5-fluoropyridine-3-carboxylate 97% | 455-70-9 | 5g | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC200409 | Methyl 5-fluoropyridine-3-carboxylate 97% | 455-70-9 | 25g | $100 | 2026-06-04 | Buy |
| Apolloscientific | PC200409 | Methyl 5-fluoropyridine-3-carboxylate 97% | 455-70-9 | 100g | $374 | 2026-06-04 | Buy |
METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Chemical Properties,Uses,Production
Chemical Properties
Light yellow solid
Uses
Methyl 5-fluoronicotinate
Synthesis
36052-25-2
455-70-9
Example 2.26: Synthesis of methyl 5-fluoronicotinate; To a stirring solution of 243 mg (1.6 mmol) of methyl 5-aminonicotinate dissolved in 5 mL of HF-pyridine at 0 °C was slowly added 119 mg (1.72 mmol) of sodium nitrite (NaNO2). The reaction mixture was stirred continuously at 0 °C for 30 min, then warmed up to 50 °C and kept for 1 hour. Upon completion of the reaction, the reaction was quenched with ice and saturated sodium bicarbonate (NaHCO3) solution. The aqueous phase was extracted with chloroform (CHCl3) and the organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Purification by fast silica gel column chromatography (eluent: 1% methanol/chloroform) afforded 139 mg of methyl 5-fluoronicotinate as a yellow solid in 56% yield.
References
[1] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 62
[2] Journal of Organic Chemistry, 1949, vol. 14, p. 328,331
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 31, p. 9896 - 9900
[4] Angew. Chem., 2018, vol. 130, p. 10044 - 10048,5
METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
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Preparation Products
METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
View Lastest Price from METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
455-70-9
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
455-70-9
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
455-70-9
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
455-70-9
- $7.00
- 99%
- Career Henan Chemical Co
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