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2-COUMARANONE

2-COUMARANONE Structure
2-COUMARANONE structure
CAS No.
553-86-6
Chemical Name:
2-COUMARANONE
Synonyms
BENZOFURANONE;2(3H)-BENZOFURANONE;2-Coumaronone;3H-BENZOFURAN-2-ONE;2-Cumaranon;2-COUMARANONE;ISOCOUMARANONE;2-Oxobenzofuran;2H-BENZOFURANONE;BENZOFURAN-2-ONE
CBNumber:
CB5131550
Molecular Formula:
C8H6O2
Molecular Weight:
134.13
MDL Number:
MFCD00005856
MOL File:
553-86-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:10:53
Product description Number Pack Size Price
2-Coumaranone 97% 124591 1g $42.1
2-Coumaranone 97% 124591 10g $183
2-Coumaranone >98.0%(GC) C1445 5g $45
2-Coumaranone >98.0%(GC) C1445 25g $144
2(3H)-Benzofuranone TRC-B203635-5G 5g $135
More product size
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2-COUMARANONE Properties

Melting point 49-51 °C(lit.)
Boiling point 248-250 °C(lit.)
Density 1,22 g/cm3
vapor pressure 0.027-0.24Pa at 10-30℃
refractive index 1.4800 (estimate)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility H2O: soluble3.8g/L at 30°C
form Crystalline Powder or Crystals
color White to yellow-orange
Water Solubility H2O: soluble 3.8g/L at30°C
BRN 114689
InChI 1S/C8H6O2/c9-8-5-6-3-1-2-4-7(6)10-8/h1-4H,5H2
InChIKey ACZGCWSMSTYWDQ-UHFFFAOYSA-N
SMILES O=C1Cc2ccccc2O1
LogP 1.347
Surface tension 63.8mN/m at 1g/L and 20℃
CAS DataBase Reference 553-86-6(CAS DataBase Reference)
FDA UNII 4K47Z4Q1E7
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H317-H319
Precautionary statements  P280-P302+P352-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-43-36/38
Safety Statements  24/25-36-26-36/37
WGK Germany  3
HS Code  29322090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
REACH Registrations Inactive
NFPA 704
1
2 0

2-COUMARANONE price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 124591 2-Coumaranone 97% 553-86-6 1g $42.1 2026-04-30 Buy
Sigma-Aldrich 124591 2-Coumaranone 97% 553-86-6 10g $183 2026-04-30 Buy
TCI Chemical C1445 2-Coumaranone >98.0%(GC) 553-86-6 5g $45 2026-04-30 Buy
TCI Chemical C1445 2-Coumaranone >98.0%(GC) 553-86-6 25g $144 2026-04-30 Buy
TRC TRC-B203635-5G 2(3H)-Benzofuranone 553-86-6 5g $135 2026-06-03 Buy
Product number Packaging Price Buy
124591 1g $42.1 Buy
124591 10g $183 Buy
C1445 5g $45 Buy
C1445 25g $144 Buy
TRC-B203635-5G 5g $135 Buy

2-COUMARANONE Chemical Properties,Uses,Production

Description

2-Coumaranone (also named as Isophthalide, 3H-benzofuran-2-one) belongs to a class of organic compounds named as benzofuranones which exhibits mutagenic and carcinogenic activity. 2-Coumaranone has been used to study the effects of coumarins on 7,12-dimethyibenz(a)anthracene induced neoplasia of the rat mammary gland and as probe for detecting enzymes which hydrolyze 2-hydroxybenzofuran structures.

Reference

Y. S. Priya, K. Ramachandra Rao, P. V. Chalapathi, M. Satyavani, A. Veeraiah, Vibrational and UV spectroscopic studies of 2-coumaranone by experimental and density functional theory calculations, Journal of Molecular Structure, 2017, vol. 1144, pp. 535-544

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

2-Coumaranone has been used to study the effects of coumarins on 7,12-dimethyibenz(a)anthracene induced neoplasia of the rat mammary gland. It was employed as probe for detecting enzymes which hydrolyze 2-hydroxybenzofuran structures.

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 2491, 1982 DOI: 10.1021/jo00133a055

Synthesis

Preparation of  2-coumarone (I) comprises reacting cyclohexanone (II) with carboxyl-containing acylating agent (III) to methyl 2-(2-oxo-cyclohexyl)-2-hydroxy-acetate (IV) and optional dehydration to a mixture (V) of methyl 2-oxo-cyclohexylidene-acetate and the enol-lactone of the acid; or direct conversion of (I) to (V); and catalytic gas phase dehydrogenation of (IV) or (V) to (I).
2-COUMARANONE

2-COUMARANONE synthesis

614-75-5
553-86-6
Synthesis of 2-COUMARANONE from 2-Hydroxyphenylacetic acid

2-COUMARANONE Preparation Products And Raw materials

Raw materials

Preparation Products

2(3H)-Benzofuranone, 3-(hydroxymethylene)-

2-COUMARANONE Suppliers

Global( 369)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Benoy Chemical Co., Ltd
+8617342059697 sales@benoychem.com China 314 58
Shanghai Cube Chemical Co., Ltd.
+86-02156500520 +86-18116101847 kevin.li@cubechem.com China 43 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 sales1@chuanghaibio.com China 5216 58
airuikechemical co., ltd. 		+86-18353166132 sales02@airuikechemical.com China 983 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Dalian Richfortune Chemicals Co., Ltd 		+86-86-411-84820922 +86-8613904096939 sales@richfortunechem.com China 305 57
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Supplier Advantage
Hangzhou Benoy Chemical Co., Ltd
58
Shanghai Cube Chemical Co., Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
airuikechemical co., ltd. 		58
Capot Chemical Co.,Ltd. 		60
Dalian Richfortune Chemicals Co., Ltd 		57
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58

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View Lastest Price from 2-COUMARANONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Coumaranone pictures 2026-05-28 2-Coumaranone
553-86-6
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
2-COUMARANONE pictures 2026-03-20 2-COUMARANONE
553-86-6
 $1.00 1PCS 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-COUMARANONE USP/EP/BP pictures 2025-11-18 2-COUMARANONE USP/EP/BP
553-86-6
 $1.10 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • 2-Coumaranone pictures
  • 2-Coumaranone
    553-86-6
  • $2.00-5.00
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD
  • 2-COUMARANONE pictures
  • 2-COUMARANONE
    553-86-6
  • $1.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

2-COUMARANONE Spectrum

2-COUMARANONE(553-86-6)MS2-COUMARANONE(553-86-6)1HNMR2-COUMARANONE(553-86-6)13CNMR2-COUMARANONE(553-86-6)IR12-COUMARANONE(553-86-6)IR22-COUMARANONE(553-86-6)Raman

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1-Benzofuran-2(3H)-one 2,3-dihydrobenzofuran-2-one Benzo[b]furan-2(3H)-one BENZOFURAN-2[3H]-ONE 2H-BENZOFURANONE 2-COUMARANONE 2,3-DIHYDROBENZO[B]FURAN-2-ONE 3H-Benzofuran-2-one~2,3-Dihydrobenzofuran-2-one GIRARD'S REAGENT P 98% 2-Coumaranone,99% 2-Cumaranon BENZOFURAN-2-ONE ISOCOUMARANONE 2-Coumaranone,97% Benzofuran-2(2H)-one 2(3H)-Benzofuranone Isocoumaranone 2-Coumaranone 97% (3H)-benzofuran-2-on 2-Coumaranone > 2-COUMARANONE USP/EP/BP Azoxystobin intermediate 2-Chlorothalidone 2(3H)-BENZOFURANONE 2-Coumaronone 3H-BENZOFURAN-2-ONE BENZOFURANONE 2-Oxobenzofuran 553-86-6 533-86-6 Building Blocks Benzofurans Heterocyclic Building Blocks Benzofurans Building Blocks Heterocyclic Building Blocks