Piclamilast
- CAS No.
- 144035-83-6
- Chemical Name:
- Piclamilast
- Synonyms
- RP 73401;RPR 73401;piclamilas;Piclamilast;Piclamilast, 10 mM in DMSO;N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide;3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide;3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide;3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide;Benzamide,3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
- CBNumber:
- CB51328847
- Molecular Formula:
- C18H18Cl2N2O3
- Molecular Weight:
- 381.25
- MDL Number:
- MOL File:
- 144035-83-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 447.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.370 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 10.10±0.70(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23) |
| InChIKey | RRRUXBQSQLKHEL-UHFFFAOYSA-N |
| SMILES | Clc1cncc(c1NC(=O)c2cc(c(cc2)OC)OC3CCCC3)Cl |
| FDA UNII | WM58D7C3ZT |
| UNSPSC Code | 41106305 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Piclamilast price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0585 | Piclamilast ≥98% (HPLC) | 144035-83-6 | 25mg | $465 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0585 | Piclamilast ≥98% (HPLC) | 144035-83-6 | 5mg | $112 | 2025-07-31 | Buy |
| Cayman Chemical | 29170 | Piclamilast ≥98% | 144035-83-6 | 1mg | $39 | 2026-04-30 | Buy |
| Cayman Chemical | 29170 | Piclamilast ≥98% | 144035-83-6 | 5mg | $136 | 2026-04-30 | Buy |
| Cayman Chemical | 29170 | Piclamilast ≥98% | 144035-83-6 | 10mg | $213 | 2026-04-30 | Buy |
Piclamilast Chemical Properties, Uses, Production
Uses
Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor. Piclamilast may offer therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease. Piclamilast may also provide a treatment option for pre-term infants with bronchopulmonary dysplasia (BPD).
Definition
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.
Biological Activity
Piclamilast is a potent and selective cyclic AMP phosphodiesterase-4 inhibitor th at exhibits equal, high affinity for both the PDE4 high- and low-affinity rolipram binding states (HARBS and LARBS). Recent studies shown th at piclamilast inhibits Trypanosoma brucei PDEB1 (TbrPDEB1) and TbrPDEB2.', 'Piclamilast is also known as N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide. Piclamilast regulates the cAMP (cyclic adenosine monophosphate) signaling pathway. It increases the retinoid-dependent transactivation and the degradation of retinoic acid receptor α (RARα).
in vivo
Piclamilast (RP 73401, 10 mg/kg, 30 min) alone does not affect the MST of leukemia-bearing animals. Piclamilast combined with ATRA (HY-14649) significantly more effective than ATRA alone in increasing the MST (40 days; interval 34–45 days) of leukemia-bearing animals[3].
| Animal Model: | SCID mice[3]. |
| Dosage: | 10 mg/kg (combined with ATRA (HY-14649)). |
| Administration: | Injection daily. |
| Result: | Significantly more effective than ATRA alone in increasing the MST (40 days; interval 34–45 days) of leukemia-bearing animals. |
IC 50
PDE4: 16 nM (IC50, in pig aorta); PDE4: 2 nM (IC50, in eosinophil soluble); PDE1: >100 μM (IC50); PDE2: 40 μM (IC50); PDE3: >100 μM (IC50); PDE5: 14 μM (IC50)
storage
Store at RT
Piclamilast Preparation Products And Raw materials
Raw materials
Preparation Products
Piclamilast Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | zwchem@163.com | China | 524 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| AN PharmaTech Co Ltd | 86(21)68097365 | sales@anpharma.net | China | 4875 | 55 |
| Shanghai Boyners Pharm-Tech Co., Ltd. | 13817873692 | mkt@boynerspharm.com | China | 1707 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
View Latest Price from Piclamilast manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Piclamilast
144035-83-6
|
$44.00-163.00 | 99.57% | 10g | TargetMol Chemicals Inc. |
-
- Piclamilast
144035-83-6
- $44.00-163.00
- 99.57%
- TargetMol Chemicals Inc.
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