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DHODH-IN-25

DHODH-IN-25 structure

CAS No.: 2619531-95-0

Chemical Name:: DHODH-IN-25

Synonyms: DHODH-IN-25;1-Pyrrolidinecarboxamide, N-[4-[[(2-chloro-6-fluorophenyl)amino]carbonyl]-2-fluoro-5-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-2-(hydroxymethyl)-5-oxo-

CBNumber:: CB514254663

Molecular Formula:: C22H19ClF5N3O5

Molecular Weight:: 535.85

MDL Number:

MOL File:: 2619531-95-0.mol

Last updated:2025-04-17 18:22:24

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DHODH-IN-25 Properties

Density	1.546±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	9.59±0.70(predicted)

DHODH-IN-25 Chemical Properties, Uses, Production

Uses

DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 nM for human DHODH. DHODH-IN-25 can be used for the study of acute myeloid leukemia (AML)[1].

References

[1] DeRatt, Lindsey G., et al. "Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors." ACS Medicinal Chemistry Letters (2024).

DHODH-IN-25 Preparation Products And Raw materials

Raw materials

Preparation Products

DHODH-IN-25 Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2994	55
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
TargetMol Chemicals Inc.	58

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DHODH-IN-25 1-Pyrrolidinecarboxamide, N-[4-[[(2-chloro-6-fluorophenyl)amino]carbonyl]-2-fluoro-5-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-2-(hydroxymethyl)-5-oxo- 2619531-95-0