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2-Amino-5-nitrothiazole

2-Amino-5-nitrothiazole Structure
2-Amino-5-nitrothiazole structure
CAS No.
121-66-4
Chemical Name:
2-Amino-5-nitrothiazole
Synonyms
5-Nitrothiazol-2-amine;ENHEPTIN;ENHEPTYNE;5-NITRO-1,3-THIAZOL-2-AMINE;Nitazoxanide Related Compound A (25 mg) (2-Amino-5-nitrothiazole);NSC 4;entramin;AKOS 203;ENTRAMINE;enheptint
CBNumber:
CB5143401
Molecular Formula:
C3H3N3O2S
Molecular Weight:
145.14
MDL Number:
MFCD00005326
MOL File:
121-66-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-12 21:25:05
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2-Amino-5-nitrothiazole Properties

Melting point 195-200 °C (dec.) (lit.)
Boiling point 345.1±15.0 °C(Predicted)
Density 1.583 (estimate)
refractive index 1.6740 (estimate)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility 95% ethanol: soluble1g/150g at 20°C
form Powder
pka 1.26±0.10(Predicted)
color Yellow
Water Solubility <0.1 g/100 mL at 20 ºC
Sensitive Light Sensitive
Merck 14,457
BRN 126797
Henry's Law Constant 1.9×106 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides.
InChI 1S/C3H3N3O2S/c4-3-5-1-2(9-3)6(7)8/h1H,(H2,4,5)
InChIKey MIHADVKEHAFNPG-UHFFFAOYSA-N
SMILES Nc1ncc(s1)[N+]([O-])=O
Toxicology and Carcinogenesis Bioassay of 2-Amino-5-Nitrothiazole for Possible Carcinogenicity (CASRN 121-66-4)
CAS DataBase Reference 121-66-4(CAS DataBase Reference)
FDA UNII 1GR77A37Z5
IARC 3 (Vol. 31, Sup 7) 1987
EPA Substance Registry System 2-Amino-5-nitrothiazole (121-66-4)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
RTECS  XJ2800000
F  8
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29341000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazardous Substances Data 121-66-4(Hazardous Substances Data)
REACH Registrations Active
NFPA 704
0
1 0

2-Amino-5-nitrothiazole price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2889 Nitazoxanide Related Compound A pharmaceutical secondary standard, certified reference material 121-66-4 50MG $601 2026-04-30 Buy
Sigma-Aldrich 133507 2-Amino-5-nitrothiazole 97% 121-66-4 25g $47.8 2026-04-30 Buy
Sigma-Aldrich 133507 2-Amino-5-nitrothiazole 97% 121-66-4 100g $170 2026-04-30 Buy
TCI Chemical A0381 2-Amino-5-nitrothiazole >98.0%(HPLC)(T) 121-66-4 25g $85 2026-04-30 Buy
TCI Chemical A0381 2-Amino-5-nitrothiazole >98.0%(HPLC)(T) 121-66-4 500g $993 2023-06-20 Buy
Product number Packaging Price Buy
PHR2889 50MG $601 Buy
133507 25g $47.8 Buy
133507 100g $170 Buy
A0381 25g $85 Buy
A0381 500g $993 Buy

2-Amino-5-nitrothiazole Chemical Properties, Uses, Production

Uses

Niltazoxanide USP Related Compound A 2-Amino-5-nitrothiazole.

Chemical Properties

greenish yellow, to orange or brown powder

Uses

2-Amino-5-nitrothiazole was used as diazo component in the synthesis of monoazo disperse dyes. It was used as matrix during matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of oligonucleotide and protein.

Definition

ChEBI: 2-Amino-5-nitrothiazole is a member of thiazoles and a C-nitro compound.

Production Methods

Early production of 2-Amino-5-nitrothiazole was based on nitration of 2-acetylaminothiazole and careful hydrolysis. Direct nitration of 2-aminothiazole gives a cleaner product and is best achieved by adding 2-aminothiazole nitrate [57530-25-3] to concentrated sulfuric acid at 0 – 10 ℃. This process and the nitration of o-anisidine are the only large-scale processes based on rearrangement of an amine nitrate, and both are potentially hazardous due to the possibility of runaway exothermic reactions.

General Description

Greenish-yellow to orange-yellow fluffy powder or a brown chunky powder. Slightly bitter taste. Used as a veterinary medicine.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Amino-5-nitrothiazole may be sensitive to light. Incompatible with nitric acid and sulfuric acid. Also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. A preparative hazard .

Fire Hazard

Flash point data for 2-Amino-5-nitrothiazole are not available. 2-Amino-5-nitrothiazole is probably combustible.

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SO,. Incompatible with HNO3 and H2SO4. An antiprotozoal agent.

Potential Exposure

2-Amino-5-nitrothiazole is a synthetic veterinary antiprotozoal agent used since 1950 to treat farm fowl and pigeons. It is also used as an intermediate in manufacturing a group of dyes known as disperse azo dyes. It is not known to occur as a natural product. People may be exposed to 2-amino-5-nitrothiazole through contact with birds treated with the drug, releases from poultry farms, and occupational exposures in the dye industry.

2-Amino-5-nitrothiazole synthesis

96-50-4
121-66-4
Synthesis of 2-Amino-5-nitrothiazole from 2-Aminothiazole

2-Amino-5-nitrothiazole Preparation Products And Raw materials

Raw materials

2-Aminothiazole Sulfuric acid Thiourea

Preparation Products

2-Chloro-5-nitrothiazole 2-[N-ethyl-4-[(5-nitrothiazol-2-yl)azo]-m-toluidino]ethyl acetate 2-Bromo-5-nitrothiazole C.I. Disperse Blue 295 press cake 3-[ethyl[3-methyl-4-[(5-nitrothiazol-2-yl)azo]phenyl]amino]propane-1,2-diol
Disperse Blue 284 DISPERSE BLUE 102 C.I. Disperse Blue 107 2-[ethyl[3-methyl-4-[(5-nitrothiazol-2-yl)azo]phenyl]amino]ethanol DISPERSE BLUE 124
Disperse Blue 339 2,2'-[3-methyl-4-(5-nitrothiazol-2-ylazo)phenylimino]bisethanol Disperse Blue 284 DISPERSE VIOLET 48 2-[ethyl[3-methyl-4-[(5-nitrothiazol-2-yl)azo]phenyl]amino]ethanol
Nitazoxanide Ethyl [(5-nitro-1,3-thiazol-2-yl)amino](oxo)acetate N-(5-nitro-2-thiazolyl)benzamide tenonitrozole Methyl 1-[[2-N-(5-Nitrothiazolyl)carboxamido]phenyl]-2,3,4- tri-O-acetyl--D-glucopyranuronate

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2-Amino-5-nitrothiazole Suppliers

Global Suppliers ( 535)
Supplier Tel Email Country ProdList Advantage
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd. 18606289633 15862625988 sales@clentchem.com China 244 60
Shijiazhuang Outejia Chemical Co. LTD 0311-87795622 sales@adonghui.com China 54 64
Hubei Jiuchang New Material Technology Co., Ltd 13407109540 15216757546@163.com China 242 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd. 60
Shijiazhuang Outejia Chemical Co. LTD 64
Hubei Jiuchang New Material Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
future industrial shanghai co., ltd 65
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

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View Latest Price from 2-Amino-5-nitrothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-5-nitrothiazole pictures 2026-09-16 2-Amino-5-nitrothiazole
121-66-4
 $350.00 200kg 99% 5 tons Anhui Royal Chemical Co., Ltd.
2-Amino-5-nitrothiazole pictures 2026-09-16 2-Amino-5-nitrothiazole
121-66-4
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Amino-5-nitrothiazole pictures 2026-08-20 2-Amino-5-nitrothiazole
121-66-4
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

2-Amino-5-nitrothiazole Spectrum

2-Amino-5-nitrothiazole(121-66-4)MS2-Amino-5-nitrothiazole(121-66-4)1HNMR2-Amino-5-nitrothiazole(121-66-4)IR12-Amino-5-nitrothiazole(121-66-4)IR22-Amino-5-nitrothiazole(121-66-4)Raman

121-66-4 (2-Amino-5-nitrothiazole) Related Search:

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Glycine Aminoethoxyvinyl glycine hydrochloride Nitrogen dioxide

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