4-Methylthiophenylacetic acid
- CAS No.
- 16188-55-9
- Chemical Name:
- 4-Methylthiophenylacetic acid
- Synonyms
- RARECHEM AL BO 0923;4-Methylthiophenylac;Etoricoxib Impurity 53;4-(Methylthio)fenylazijnzuur;4-(methylthio)ohenylacetic acid;4-(METHYLTHIO)PHENYLACETIC ACID;4-(Methylthio)benzeneacetic acid;4-(Methylthio)phenylacetic acid,98%;4-(Methylthio)phenylacetic acid 99%;2-(4-(methylthio)phenyl)acetic acid
- CBNumber:
- CB5145142
- Molecular Formula:
- C9H10O2S
- Molecular Weight:
- 182.24
- MDL Number:
- MFCD00192325
- MOL File:
- 16188-55-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(Methylthio)phenylacetic acid 99% | 396591 | 1g | $60.7 |
| 4-(Methylthio)phenylacetic Acid >98.0%(GC)(T) | M2874 | 1g | $48 |
| 4-(Methylthio)phenylacetic Acid >98.0%(GC)(T) | M2874 | 5g | $152 |
| 4-(Methylthio)phenylacetic Acid | M725578 | 50mg | $60 |
| 4-(Methylthio)phenylacetic Acid | D365 | 5g | $41 |
| More product size | |||
| Melting point | 97-98 °C(lit.) |
|---|---|
| Boiling point | 337.4±25.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | powder to crystal |
| pka | 4.34±0.10(Predicted) |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C9H10O2S/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H,6H2,1H3,(H,10,11) |
| InChIKey | AHMLFHMRRBJCRM-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=C(SC)C=C1 |
| CAS DataBase Reference | 16188-55-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29309099 | |||||||||
| NFPA 704 |
|
4-Methylthiophenylacetic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 396591 | 4-(Methylthio)phenylacetic acid 99% | 16188-55-9 | 1g | $60.7 | 2025-07-31 | Buy |
| TCI Chemical | M2874 | 4-(Methylthio)phenylacetic Acid >98.0%(GC)(T) | 16188-55-9 | 1g | $48 | 2025-07-31 | Buy |
| TCI Chemical | M2874 | 4-(Methylthio)phenylacetic Acid >98.0%(GC)(T) | 16188-55-9 | 5g | $152 | 2025-07-31 | Buy |
| TRC | M725578 | 4-(Methylthio)phenylacetic Acid | 16188-55-9 | 50mg | $60 | 2021-12-16 | Buy |
| AK Scientific | D365 | 4-(Methylthio)phenylacetic Acid | 16188-55-9 | 5g | $41 | 2021-12-16 | Buy |
4-Methylthiophenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
Cream crystalline powder
General Description
TiO2 photocatalytic one-electron oxidation of 4-(methylthio)phenylacetic acid has been reported by time-resolved diffuse reflectance spectroscopy.
Synthesis
1878-66-6
5188-07-8
16188-55-9
1. 10 g of 4-bromophenylacetic acid was dissolved in 20 mL of DMF under nitrogen protection. 2. 5.0 g of sodium methanethiol and 0.5 g of copper powder were added for nitrogen displacement. 3. The reaction mixture was heated to 130 °C under nitrogen protection and the reaction was stirred for 24 hours. 4. After the reaction was completed, it was cooled to room temperature. 5. The reaction mixture was processed according to the method of Example 1 to finally obtain 4-methylthiophenylacetic acid in 79.3% yield. Alternative steps: 1. 10 g of 4-bromophenylacetic acid was dissolved in 20 mL of DMF under nitrogen protection. 2. 5.0 g of sodium methanethiol and 0.1 g of cuprous bromide were added for nitrogen substitution. 3. The reaction mixture was heated to 130 °C under nitrogen protection and the reaction was stirred for 4 hours. 4. Upon completion of the reaction, the mixture was cooled to room temperature, 5mL of 40% NaOH solution was added and stirred for 10 minutes. 5. Extracted twice with 25mL of ethyl acetate and combined the organic phases. 6. Add 50mL of ethyl acetate and adjust pH to 2-4 with 10% dilute sulfuric acid. 7. Collect the ethyl acetate layer and wash with 10mL of water. 8. Concentrate ethyl acetate to about 20mL by distillation, add 20mL hexane. 9. Heat to reflux to completely dissolve the solid, slowly cool to room temperature and filter to obtain yellow crystals. 10. 6.38g of 4-methylthiophenylacetic acid was obtained after drying in 76.1% yield.
References
[1] Patent: CN105646306, 2016, A. Location in patent: Paragraph 0011
4-Methylthiophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8422 | 58 |
View Lastest Price from 4-Methylthiophenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-07-25 | 4-Methylthiophenylacetic acid
16188-55-9
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-04-04 | 4-Methylthiophenylacetic acid
16188-55-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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2019-07-14 | 4-Methylthiophenylacetic acid
16188-55-9
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 4-Methylthiophenylacetic acid
16188-55-9
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Methylthiophenylacetic acid
16188-55-9
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Methylthiophenylacetic acid
16188-55-9
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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