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ChemicalBook >> CAS DataBase List >>2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]-

2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]-

2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- Structure
2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- structure
CAS No.
2989271-65-8
Chemical Name:
2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]-
Synonyms
P2Y14R antagonist 2;2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]-
CBNumber:
CB514685751
Molecular Formula:
C18H13FN2O4S
Molecular Weight:
372.37
MDL Number:
MOL File:
2989271-65-8.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:25
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2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- Properties

Boiling point 471.2±45.0 °C(predicted)
Density 1.462±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 3.78±0.10(predicted)

2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1136927 P2Y14R antagonist 2 99.56% 2989271-65-8 5mg $390 2026-06-04 Buy
ChemScene CS-1136927 P2Y14R antagonist 2 99.56% 2989271-65-8 10mg $623 2026-06-04 Buy
ChemScene CS-1136927 P2Y14R antagonist 2 99.56% 2989271-65-8 25mg $1246 2026-06-04 Buy
ChemScene CS-1136927 P2Y14R antagonist 2 99.56% 2989271-65-8 50mg $2004 2026-06-04 Buy
Arctom HY-162661 P2Y14R antagonist 2 99.56% 2989271-65-8 5mg $342 2026-05-26 Buy
Product number Packaging Price Buy
CS-1136927 5mg $390 Buy
CS-1136927 10mg $623 Buy
CS-1136927 25mg $1246 Buy
CS-1136927 50mg $2004 Buy
HY-162661 5mg $342 Buy

2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- Chemical Properties, Uses, Production

Uses

P2Y14R antagonist 2 (compound 39) is a potent, selective and orally active P2Y14R antagonist with an IC50 value of 0.40 nM. P2Y14R antagonist 2 shows anti-inflammatory activity. P2Y14R antagonist 2 has the potential for the research of colitis[1].

in vivo

P2Y14R antagonist 2 (50, 100 μM for 100μL per mice; rectally administered, daily for 7 days) shows anti-inflammatory activity in mice with colitis[1].
Pharmacokinetic Parameters[1].

Parametersdose (mg/kg)Cmax (ng/mL)T1/2 (min)Tmax (min)AUCall (min*ng/mL)CL (mL/min/kg)F (%)
iv1.0-21 ± 8.4-27924 ± 5520133.8 ± 33-
po5.0518.25 ± 196.26177.6 ± 24.61590744 ± 21613232.2 ± 46.265.0
Animal Model:6-8 weeks, 20-22 g, male C57BL/6 mice (colitis) [1]
Dosage:50, 100 μM for 100μL per mice
Administration:Rectally administered, daily for 7 days
Result:Alleviated DSS-induced body weight loss, loose stools, rectal bleeding, colon shortening, and elevated spleen weighted index.

IC 50

P2Y14 Receptor: 0.40 nM (IC50)

References

[1] Wang YH, et al. Discovery of a Series of 4-Amide-thiophene-2-carboxyl Derivatives as Highly Potent P2Y14 Receptor Antagonists for Inflammatory Bowel Disease Treatment. J Med Chem. 2024 Jul 3. DOI:10.1021/acs.jmedchem.4c00699

2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
TargetMol Chemicals Inc. 58

2989271-65-8 (2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]-) Related Search:

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2-Thiophenecarboxylic acid, 5-[(5-fluoro-2-pyridinyl)oxy]-4-[(4-methylbenzoyl)amino]- P2Y14R antagonist 2 2989271-65-8