N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide
![N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide Structure](CAS/20200515/GIF/171964-73-1.gif)
- CAS No.
- 171964-73-1
- Chemical Name:
- N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide
- Synonyms
- ZD-0892;ZD0892,ZD 0892;N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide;L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-;(S)-1-((4-Methoxybenzoyl)-L-valyl)-N-((S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)pyrrolidine-2-carboxamide;(S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxamide
- CBNumber:
- CB51476726
- Molecular Formula:
- C24H32F3N3O5
- Molecular Weight:
- 499.52
- MDL Number:
- MFCD00942206
- MOL File:
- 171964-73-1.mol
- MSDS File:
- SDS
N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide Properties
| Boiling point | 677.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.227±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.20±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | KXL5BC5A6F |
N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0014993 | ZD-0892 95.0% | 171964-73-1 | 5mg | $395 | 2026-06-04 | Buy |
| ChemScene | CS-0014993 | ZD-0892 95.0% | 171964-73-1 | 10mg | $634 | 2026-06-04 | Buy |
| ChemScene | CS-0014993 | ZD-0892 95.0% | 171964-73-1 | 25mg | $1267 | 2026-06-04 | Buy |
| ChemScene | CS-0014993 | ZD-0892 95.0% | 171964-73-1 | 50mg | $2031 | 2026-06-04 | Buy |
| ChemScene | CS-0014993 | ZD-0892 95.0% | 171964-73-1 | 100mg | $3250 | 2026-06-04 | Buy |
N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide Chemical Properties, Uses, Production
Uses
ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
in vivo
ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis[1]. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats[2].
References
[1] Lee JK, et al. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Nat Med. 1998 Dec;4(12):1383-91. DOI:10.1038/3973
[2] Cowan KN, et al. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med. 2000 Jun;6(6):698-702. DOI:10.1038/76282
N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(4-Methoxybenzoyl)-L-valyl]-N-[(1S)-3,3,3-Tr ifluor-1-isopropyl2-oxopropyl]-L-prolinamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9988 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
