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CETRORELIX

CETRORELIX Structure
CETRORELIX structure
CAS No.
145672-81-7
Chemical Name:
CETRORELIX
Synonyms
Cetrorelix impurity;Ns 75a;D 20761;Ovurelix;Cetrotid;Sb 075 acetate;SB-075 ACETATE;NS-75A;Cetrorelix( x acetate);Cetrorelix acetate (SB-75);Cetrorelix Acetate, 10 mM in DMSO
CBNumber:
CB51478311
Molecular Formula:
C70H92ClN17O14.C2H4O2
Molecular Weight:
1491.11
MDL Number:
MFCD08459466
MOL File:
145672-81-7.mol
Last updated:2025-09-17 10:44:43
Product description Number Pack Size Price
Cetrorelix acetate ≥98% (HPLC) C5249 5mg $126.35
Cetrorelix acetate ≥98% (HPLC) C5249 25mg $503.5
Cetrorelix (acetate) ≥95% 23910 1mg $40
Cetrorelix (acetate) ≥95% 23910 5mg $99
Cetrorelix (acetate) ≥95% 23910 10mg $158
More product size
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CETRORELIX Properties

storage temp. -20°C
solubility methanol: soluble10%
form solid
color White to off-white
Water Solubility Soluble in water
Sequence N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2
InChIKey KFEFLCOCAHJBEA-YIQVFHPZNA-N
NCI Dictionary of Cancer Terms D-20761
FDA UNII XPQ226310Q
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360F
Precautionary statements  P201-P280-P308+P313
Risk Statements  60-63
Safety Statements  22
WGK Germany  3

CETRORELIX price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C5249 Cetrorelix acetate ≥98% (HPLC) 145672-81-7 5mg $126.35 2025-07-31 Buy
Sigma-Aldrich C5249 Cetrorelix acetate ≥98% (HPLC) 145672-81-7 25mg $503.5 2025-07-31 Buy
Cayman Chemical 23910 Cetrorelix (acetate) ≥95% 145672-81-7 1mg $40 2024-03-01 Buy
Cayman Chemical 23910 Cetrorelix (acetate) ≥95% 145672-81-7 5mg $99 2024-03-01 Buy
Cayman Chemical 23910 Cetrorelix (acetate) ≥95% 145672-81-7 10mg $158 2024-03-01 Buy
Product number Packaging Price Buy
C5249 5mg $126.35 Buy
C5249 25mg $503.5 Buy
23910 1mg $40 Buy
23910 5mg $99 Buy
23910 10mg $158 Buy

CETRORELIX Chemical Properties,Uses,Production

Description

Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model. Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide with 65% to 86% PMF survival compared to 46% PMF survival with a saline control. Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.

Uses

Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.

Uses

Cetrorelix, a luteinizing hormone releasing hormone receptor (LHRHR) antagonist, was used to study its safety, mechanism of action, metabolism, and efficacy as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). Cetrorelix is used to evaluate its effects on a wide range of physiological processes and malignancies that involve luteinizing hormone releasing hormone receptor signaling pathways involving processes such as steroidogenesis.

Definition

ChEBI: The acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.

Biochem/physiol Actions

Cetrorelix acetate is a luteinizing hormone releasing hormone receptor antagonist. It causes prepubertal reduction in bone modeling, bone density and bone strength comparable to post-menopausal bone loss.

storage

Store at -20°C

References

[1] THOMAS BECKERS  Peter H  Helmut Reil?nder. Characterization of Gonadotropin-Releasing Hormone Analogs Based on a Sensitive Cellular Luciferase Reporter Gene Assay[J]. Analytical biochemistry, 1997, 251 1: Pages 17-23. DOI: 10.1006/abio.1997.2208
[2] T YANO. Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone-releasing hormone antagonist SB-75.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 15: 7090-7094. DOI: 10.1073/pnas.91.15.7090
[3] DROR MEIROW. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice.[J]. Human reproduction, 2004, 19 6: 1294-1299. DOI: 10.1093/humrep/deh257

CETRORELIX Preparation Products And Raw materials

Raw materials

Preparation Products

CETRORELIX Suppliers

Global( 125)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16517 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Cellmano Biotech Limited 		0551-65326643 18156095617 info@cellmano.com China 995 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
Longyan Tianhua Biological Technology Co., Ltd 		0086 18039857276 18039857276 CHINA 2783 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
Cellmano Biotech Limited 		58
TargetMol Chemicals Inc. 		58
Longyan Tianhua Biological Technology Co., Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from CETRORELIX manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cetrorelix Acetate pictures 2025-10-13 Cetrorelix Acetate
145672-81-7
 US $2.00-5.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Cetrorelix Acetate pictures 2025-09-17 Cetrorelix Acetate
145672-81-7
 US $40.00-123.00 / mg 98.00% 10g TargetMol Chemicals Inc.
Cetrorelix pictures 2025-02-17 Cetrorelix
145672-81-7
 US $0.00-0.00 / box 1box 99% 1000 Shandong Huizhihan Supply Chain Co., Ltd
  • Cetrorelix Acetate pictures
  • Cetrorelix Acetate
    145672-81-7
  • US $2.00-5.00 / kg
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • Cetrorelix pictures
  • Cetrorelix
    145672-81-7
  • US $0.00-0.00 / box
  • 99%
  • Shandong Huizhihan Supply Chain Co., Ltd

145672-81-7(CETRORELIX)Related Search:

Cetrorelix acetate CETRORELIX CETRORELIX cetrorelix Acetylated cetrorelix NA
CETRORELIX ACETATE (Sitraric Acetate) Deamidated cetrorelix AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-NH2, ACETATE Cetrorelix trifluoroacetate Cetrorelix acetate

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D 20761 D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt) Ns 75a Sb 075 acetate Cetrorelix Acetate,SB-075 acetate,NS-75A, >98% Cetrorelix impurity SB-075 ACETATE;NS-75A Cetrotid Ovurelix N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetic acid salt Cetrorelix( x acetate) Cetrorelix acetate (SB-75) Cetrorelix AcetateQ: What is Cetrorelix Acetate Q: What is the CAS Number of Cetrorelix Acetate Q: What is the storage condition of Cetrorelix Acetate Q: What are the applications of Cetrorelix Acetate SB-75,GnRH Receptor,Cetrorelix Acetate,Inhibitor,SB 75,Gonadotropin releasing hormone receptor,inhibit,SB75,GNRHR (S)-N-((R)-1-Amino-1-oxopropan-2-yl)-1-((2S,5S,8R,11S,14S,17R,20R,23R)-20-(4-chlorobenzyl)-2-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-8-(3-ureid Cetrorelix Acetate, 10 mM in DMSO Cetrorelix Acetate，SB-075 acetate，NS-75A 145672-81-7 C70H92ClN17O14xC2H4O2 Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals