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Methyl 4-amino-3,5-dichlorobenzoate

Methyl 4-amino-3,5-dichlorobenzoate structure

CAS No.: 41727-48-4

Chemical Name:: Methyl 4-amino-3,5-dichlorobenzoate

Synonyms: Methyl 4-amino-3,5-dichlorobenzoate;4-Amino-3,5-dichlorobenzoic acid methyl ester;Benzoicacid, 4-amino-3,5-dichloro-, methyl ester

CBNumber:: CB5149847

Molecular Formula:: C8H7Cl2NO2

Molecular Weight:: 220.05

MDL Number:: MFCD08436086

MOL File:: 41727-48-4.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:12

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Methyl 4-amino-3,5-dichlorobenzoate Properties

Melting point	79-81
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
Appearance	White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332-H312-H315-H302-H335-H319
Precautionary statements	P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362
HS Code	2916399090

Methyl 4-amino-3,5-dichlorobenzoate price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	RBA72748	Methyl 4-amino-3,5-dichlorobenzoate	41727-48-4	10g	$472	2026-06-05	Buy
Apolloscientific	OR6766	Methyl 4-amino-3,5-dichlorobenzoate >97%	41727-48-4	1g	$21	2026-06-04	Buy
Apolloscientific	OR6766	Methyl 4-amino-3,5-dichlorobenzoate >97%	41727-48-4	5g	$48	2026-06-04	Buy
Activate Scientific	AS47465	Methyl 4-amino-3,5-dichlorobenzoate 97%	41727-48-4	1g	$25	2026-06-04	Buy
Apolloscientific	OR6766	Methyl 4-amino-3,5-dichlorobenzoate >97%	41727-48-4	25g	$229	2026-06-04	Buy

Product number	Packaging	Price	Buy
RBA72748	10g	$472	Buy
OR6766	1g	$21	Buy
OR6766	5g	$48	Buy
AS47465	1g	$25	Buy
OR6766	25g	$229	Buy

Methyl 4-amino-3,5-dichlorobenzoate Chemical Properties, Uses, Production

Synthesis

67-56-1

56961-25-2

41727-48-4

General procedure for the synthesis of methyl 4-amino-3,5-dichlorobenzoate from methanol and 4-amino-3,5-dichlorobenzoic acid: Thionyl chloride (2.14 g, 0.018 mol) was slowly added dropwise to methanol (10 mL) via a syringe under the condition of -3 to -4 °C. The reaction temperature was controlled not to exceed -1.1 °C during the dropwise addition, and the time of the dropwise addition was about 35 min. After the dropwise addition, the reaction mixture was stirred at 0 °C or lower for 1 hour. Subsequently, 4-amino-3,5-dichlorobenzoic acid (0.75 g, 3.6 mmol) [ACROS Organics] was added in a single addition. The reaction mixture was stirred at room temperature for about 3 days until the reaction was complete. After completion of the reaction, the homogeneous reaction mixture was concentrated under vacuum. Water (6 mL) was added to the concentrated residue and sodium bicarbonate (0.36 g, 4.3 mmol) was added all at once and stirred for 30 minutes at room temperature. The mixture was extracted several times with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under vacuum to afford methyl 4-amino-3,5-dichlorobenzoate 0.79 g (quantitative yield) as a brown solid product. Mass spectrum (MS): m/z 220 (MH+). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 500 MHz, DMSO-d6): δ 3.780 (s, 3H), 6.407 (br s, 2H), 7.731 (s, 2H).

References

[1] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 116
[2] Patent: WO2015/167795, 2015, A1. Location in patent: Page/Page column 29

Methyl 4-amino-3,5-dichlorobenzoate Preparation Products And Raw materials

Raw materials

Methanol 4-Amino-3,5-dichlorobenzoic acid

Preparation Products

Methyl 4-amino-3,5-dichlorobenzoate Suppliers

Global Suppliers ( 53)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing ShengSai Chemical Co., Ltd.	025-85205967 13951876367	shengsaichem@163.com	China	818	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Mashilabs (Shanghai) Co.,Ltd.	19916721580	mafarm@126.com	China	4534	58
Shanghai Yongye Biotechnology Co., Ltd.	86-021-61559134 15921386130	3423497944@qq.com	China	8135	55
Quzhou AMK BioTech Co., Ltd	0570-3081766 18357083060	sales@qzamkbio.com	China	1199	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
BePharm Ltd	400-685-9117	market@bepharm.com	China	15081	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Shanghai CR Corporation Limited	13917420128 13062833949	fred.wen@crcorporation.cn	China	9769	58
Dalian lichuang Chemical Co., Ltd	0411-0411-00000000 13644282108	3500508746@qq.com	China	2942	55

Supplier	Advantage
Nanjing ShengSai Chemical Co., Ltd.	58
Bide Pharmatech Ltd.	60
Mashilabs (Shanghai) Co.,Ltd.	58
Shanghai Yongye Biotechnology Co., Ltd.	55
Quzhou AMK BioTech Co., Ltd	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
BePharm Ltd	60
Amadis Chemical Company Limited	58
Shanghai CR Corporation Limited	58
Dalian lichuang Chemical Co., Ltd	55

Methyl 4-amino-3,5-dichlorobenzoate Spectrum

METHYL 4-AMINO-3,5-DICHLOROBENZOATE(41727-48-4)¹HNMR

41727-48-4 (Methyl 4-amino-3,5-dichlorobenzoate) Related Search:

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4-Amino-3,5-dichlorobenzoic acid methyl ester Benzoicacid, 4-amino-3,5-dichloro-, methyl ester Methyl 4-amino-3,5-dichlorobenzoate 41727-48-4