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Methyl 4-amino-3-(trifluoromethoxy)benzoate

Methyl 4-amino-3-(trifluoromethoxy)benzoate structure

CAS No.: 457097-93-7

Chemical Name:: Methyl 4-amino-3-(trifluoromethoxy)benzoate

Synonyms: Methyl 4-amino-3-(trifluoromethoxy)benzoate;3-trifluoromethoxy-4-aminobenzoate methyl ester;Benzoic acid, 4-amino-3-(trifluoromethoxy)-, methyl ester

CBNumber:: CB12688652

Molecular Formula:: C9H8F3NO3

Molecular Weight:: 235.16

MDL Number:: MFCD15527567

MOL File:: 457097-93-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:27:41

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Methyl 4-amino-3-(trifluoromethoxy)benzoate Properties

storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Appearance	Yellow to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338
HS Code	2918290090

Methyl 4-amino-3-(trifluoromethoxy)benzoate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	HTA09793	Methyl 4-amino-3-(trifluoromethoxy)benzoate	457097-93-7	2.5g	$354	2026-06-04	Buy
Apolloscientific	PC53602	Methyl 4-amino-3-(trifluoromethoxy)benzoate 95%	457097-93-7	250mg	$25	2026-06-04	Buy
Apolloscientific	PC53602	Methyl 4-amino-3-(trifluoromethoxy)benzoate 95%	457097-93-7	1g	$32	2026-06-04	Buy
Apolloscientific	PC53602	Methyl 4-amino-3-(trifluoromethoxy)benzoate 95%	457097-93-7	5g	$98	2026-06-04	Buy
Apolloscientific	PC53602	Methyl 4-amino-3-(trifluoromethoxy)benzoate 95%	457097-93-7	10g	$160	2026-06-04	Buy

Product number	Packaging	Price	Buy
HTA09793	2.5g	$354	Buy
PC53602	250mg	$25	Buy
PC53602	1g	$32	Buy
PC53602	5g	$98	Buy
PC53602	10g	$160	Buy

Methyl 4-amino-3-(trifluoromethoxy)benzoate Chemical Properties,Uses,Production

Synthesis

4-Amino-3-(trifluoromethoxy)benzoic acid

175278-22-5

67-56-1

Methyl 4-amino-3-(trifluoromethoxy)benzoate

457097-93-7

Thionyl chloride (2.68 g, 0.023 mol) was slowly added dropwise to methanol (12 mL) via a syringe at -5 °C, ensuring that the reaction temperature did not exceed -4 °C. After the dropwise addition was completed, the reaction mixture was stirred continuously at -5 °C or lower for 1 hour. Subsequently, 4-amino-3-(trifluoromethoxy)benzoic acid (0.5 g, 0.003 mol) [Alfa Aesar] was added all at once. The reaction mixture was transferred to ambient temperature and stirred for 3 days. After completion of the reaction, the solvent was removed by vacuum concentration. Water (10 mL) was added to the residue and sodium bicarbonate (0.46 g, 5.4 mmol) was added all at once and stirred at ambient temperature for 30 min. The mixture was extracted several times using ethyl acetate. The organic phases were combined, dried with sodium sulfate, filtered and concentrated in vacuum to afford methyl 4-amino-3-(trifluoromethoxy)benzoate 1.02 g (96.2% yield), which was initially a reddish oily material, and gradually transformed to a brown solid after cooling. Mass Spectrometry (MS): m/z 236.1 (MH+). 1H NMR (500MHz, DMSO-d6) data: δ3.771 (s, 3H), 6.329 (s, 2H), 6.834 (d, 1H), 7.6181 (s, 1H), 7.655 (dd, 1H).

References

[1] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 92
[2] Patent: US2015/175557, 2015, A1. Location in patent: Paragraph 0300
[3] Patent: EP2017263, 2009, A1. Location in patent: Page/Page column 213
[4] Patent: US2013/115194, 2013, A1. Location in patent: Paragraph 0335
[5] Patent: US2013/287731, 2013, A1. Location in patent: Paragraph 0284; 0285

Methyl 4-amino-3-(trifluoromethoxy)benzoate Preparation Products And Raw materials

Raw materials

4-Amino-3-(trifluoromethoxy)benzoic acid Methanol 4-Bromo-2-(trifluoromethoxy)aniline carbon monoxide

Preparation Products

4-Chloro-3-(trifluoromethoxy)benzoic acid

Methyl 4-amino-3-(trifluoromethoxy)benzoate Suppliers

Global( 31)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Anxuan Chemical, Co., Ltd.	13912302692	sales@anxuanchem.com	China	4824	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
LinkChem Technology Co., Ltd.	021-58950110 13124863828	sales@linkchem.cn	China	2996	58
Aikon International Limited	025-66061636 19370895928	qqyang@aikonchem.com	China	15810	58
SHANGHAI FDC-CHEMICAL CO.,LTD	021-61469567 13774476675	sales@fdc-chemical.com	China	10000	58
Rhawn Reagent	400-400-1332688 18019345275	huyue@rhawn.cn	China	14942	58
Allfluoro Pharmaceutical Company Limited	+86-400-0216110 +86-15958047586	sales@allfluoro.com	China	11380	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25333	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14301	58

Supplier	Advantage
Changzhou Anxuan Chemical, Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Amadis Chemical Company Limited	58
LinkChem Technology Co., Ltd.	58
Aikon International Limited	58
SHANGHAI FDC-CHEMICAL CO.,LTD	58
Rhawn Reagent	58
Allfluoro Pharmaceutical Company Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58

Methyl 4-amino-3-(trifluoromethoxy)benzoate Spectrum

Methyl 4-amino-3-(trifluoromethoxy)benzoate(457097-93-7)¹HNMR

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Methyl 4-amino-3-(trifluoromethoxy)benzoate Benzoic acid, 4-amino-3-(trifluoromethoxy)-, methyl ester 3-trifluoromethoxy-4-aminobenzoate methyl ester 457097-93-7