ChemicalBook >> CAS DataBase List >>6-Boc-3,6-diazabicyclo[3.2.0]heptane

6-Boc-3,6-diazabicyclo[3.2.0]heptane

6-Boc-3,6-diazabicyclo[3.2.0]heptane structure

CAS No.: 122848-57-1

Chemical Name:: 6-Boc-3,6-diazabicyclo[3.2.0]heptane

Synonyms: 6-Boc-3,6-diazabicyclo[3.2.0]heptane;tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate - [D6474];3,6-Diaza-bicyclo[3.2.0]heptane-6-carboxylic acid tert-butyl ester;cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid tert-butylester;3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid, 1,1-dimethylethyl ester

CBNumber:: CB51519627

Molecular Formula:: C10H18N2O2

Molecular Weight:: 198.26

MDL Number:: MFCD12198656

MOL File:: 122848-57-1.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:13

Request For Quotation

6-Boc-3,6-diazabicyclo[3.2.0]heptane Properties

Boiling point	276.4±13.0 °C(Predicted)
Density	1.104±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
pka	10.65±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H312+H332-H314-H361-H335-H402-H290
Precautionary statements	P501-P261-P273-P270-P202-P234-P201-P271-P264-P280-P390-P308+P313-P362+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P406-P405

6-Boc-3,6-diazabicyclo[3.2.0]heptane price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	56161	6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE 95%	122848-57-1	0.1G	$47	2026-04-30	Buy
AstaTech	56161	6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE 95%	122848-57-1	0.25G	$75	2026-04-30	Buy
AstaTech	56161	6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE 95%	122848-57-1	1G	$267	2026-04-30	Buy
Matrix Scientific	122410	cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid tert-butylester	122848-57-1	100.00mg	$59	2026-05-18	Buy
Matrix Scientific	122410	cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid tert-butylester	122848-57-1	250.00mg	$112	2026-05-18	Buy

Product number	Packaging	Price	Buy
56161	0.1G	$47	Buy
56161	0.25G	$75	Buy
56161	1G	$267	Buy
122410	100.00mg	$59	Buy
122410	250.00mg	$112	Buy

6-Boc-3,6-diazabicyclo[3.2.0]heptane Chemical Properties, Uses, Production

Synthesis

(1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

370880-79-8

122848-57-1

3-Benzyl-6-tert-butyl-3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate (2.61 mmol) was used as a raw material and dissolved in methanol (0.1 M) in a Parr vial. Palladium/carbon catalyst (Johnson Mathey, 5% wt, 61.1% H2O, 60 mg) was added. The mixture was placed on a Parr shaker and the air was removed by vacuum. The system was purged repeatedly with nitrogen followed by shaking at 15 PSI for about 1.5 hr. The progress of the reaction was monitored by TLC to confirm complete consumption of raw materials. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated to afford a viscous clear residue, tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate, in 66.1% yield. The product was sufficiently pure to be used in subsequent reactions without further purification. Mass spectrometry (ESI) calculated value: C10H18N2O2, 198.26; measured value: m/z 199.2 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 4.73-4.50 (m, 1H), 3.98 (t, J = 8.3 Hz, 1H), 3.46-3.15 (m, 2H), 3.09-2.99 (m , 1H), 2.93-2.82 (m, 1H), 2.73-2.62 (m, 1H), 2.53-2.42 (m, 1H), 2.31 (s, 1H), 1.43 (s, 9H).

References

[1] Patent: WO2011/50200, 2011, A1. Location in patent: Page/Page column 60-61
[2] Patent: WO2011/50202, 2011, A1. Location in patent: Page/Page column 50

6-Boc-3,6-diazabicyclo[3.2.0]heptane synthesis

Synthesis of 6-Boc-3,6-diazabicyclo[3.2.0]heptane from (1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

6-Boc-3,6-diazabicyclo[3.2.0]heptane Preparation Products And Raw materials

Raw materials

benzyl allyl(2-oxoethyl)carbaMate CarbaMic acid, N-(2,2-diMethoxyethyl)-N-2-propen-1-yl-, phenylMethyl ester 3-Cbz-3,6-diazabicyclo[3.2.0]heptane Benzyl allyl[2-(hydroxyimino)ethyl]carbamate (1R,5S)-3-benzyl 6-tert-butyl 3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate

3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine 1-Cbz-3-aMino-4-hydroxyMethylpyrrolidine Hydrogen Methanol

1of2

Preparation Products

6-Boc-3,6-diazabicyclo[3.2.0]heptane Suppliers

Global Suppliers ( 69)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Asfam Pharmaceutical Technology Co., Ltd.	02558867862; 18751812725	sales@ace-pharm.com	China	1977	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
PharmaBlock Sciences (Nanjing),Inc.	025-86918202 4000255188	sales@pharmablock.com	China	5000	55
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Santai Labs, Inc.	519-85601385	marketing@santailabs.com	China	891	62
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Porse Fine Chemical Co.,LTD	20-66003216 18666003216	info@porsefinechemical.com	China	1963	62
SanoChem (Chengdu) Tech. Co., Ltd.	28-87999436 02887999436	sales@sano-chem.com	China	3792	55
SPIRO PHARMA		eric_feng1954@126.com	China	9239	55

Supplier	Advantage
Nanjing Asfam Pharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
PharmaBlock Sciences (Nanjing),Inc.	55
Wuhan Chemwish Technology Co., Ltd	56
Santai Labs, Inc.	62
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Bide Pharmatech Ltd.	60
Porse Fine Chemical Co.,LTD	62
SanoChem (Chengdu) Tech. Co., Ltd.	55
SPIRO PHARMA	55

6-Boc-3,6-diazabicyclo[3.2.0]heptane Spectrum

6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE(122848-57-1)¹HNMR

122848-57-1 (6-Boc-3,6-diazabicyclo[3.2.0]heptane) Related Search:

tert-butyl 1-oxa-6-azaspiro[3,3]heptane-6-carboxylate 6-Boc-3,6-diazabicyclo[3.2.0]heptane 3,6-Diazabicyclo[3.2.0]heptane 3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine tert-butyl (1S,5R)-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylate

3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid, 1,1-diMethylethyl ester, (1R,5S)-

1of2

3,6-Diaza-bicyclo[3.2.0]heptane-6-carboxylic acid tert-butyl ester cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid tert-butylester 3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid, 1,1-dimethylethyl ester tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate - [D6474] 6-Boc-3,6-diazabicyclo[3.2.0]heptane 122848-57-1