5-Nitro-1,3-benzoxazole
- CAS No.
- 70886-33-8
- Chemical Name:
- 5-Nitro-1,3-benzoxazole
- Synonyms
- 5-Nitrobenzoxazole;Benzoxazole, 5-nitro-;5-Nitro-1,3-benzoxazole
- CBNumber:
- CB5154128
- Molecular Formula:
- C7H4N2O3
- Molecular Weight:
- 164.12
- MDL Number:
- MFCD01359855
- MOL File:
- 70886-33-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HazardClass | IRRITANT |
| HS Code | 2934999090 |
5-Nitro-1,3-benzoxazole price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR60169 | 5-Nitro-1,3-benzoxazole ≥95% | 70886-33-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR60169 | 5-Nitro-1,3-benzoxazole ≥95% | 70886-33-8 | 5g | $48 | 2026-06-04 | Buy |
| Matrix Scientific | 045160 | 5-Nitro-1,3-benzoxazole | 70886-33-8 | 10.00g | $65 | 2026-05-18 | Buy |
| Matrix Scientific | 045160 | 5-Nitro-1,3-benzoxazole | 70886-33-8 | 25.00g | $160 | 2026-05-18 | Buy |
| Matrix Scientific | 045160 | 5-Nitro-1,3-benzoxazole | 70886-33-8 | 100.00g | $628 | 2026-05-18 | Buy |
5-Nitro-1,3-benzoxazole Chemical Properties,Uses,Production
Uses
5-Nitrobenzoxazole is a useful reactant for copper-catalyzed direct carboxylation of C-H bonds in benzoxazoles and related compounds with carbon dioxide.
Synthesis
122-51-0
99-57-0
70886-33-8
To a 50 mL single-necked round-bottomed flask equipped with a magnetic stirrer was added 2-amino-4-nitrophenol (5.0 mmol, 1.0 eq.) and triethyl orthoformate (60.0 mmol, 12.0 eq.). The reaction mixture was slowly heated to 150 °C and the reaction was stirred at this temperature for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by distillation under reduced pressure to remove the excess triethyl orthoformate and the resulting ethanol by-product. The crude product was purified by silica gel column chromatography to give the final target compound 5-nitrobenzoxazole (see Table S-2).
References
[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 48, p. 11511 - 11515
[2] Journal of the Chinese Chemical Society, 2015, vol. 62, # 5, p. 412 - 419
[3] Tetrahedron, 2013, vol. 69, # 32, p. 6627 - 6633
[4] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 1029 - 1034
[5] Angewandte Chemie - International Edition, 2009, vol. 48, # 48, p. 9127 - 9130
5-Nitro-1,3-benzoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 qq272369594;2159423853qq | 2723695949@qq.com | China | 4991 | 50 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
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