[D-Trp8]-γ-MSH (trifluoroacetate salt)
- CAS No.
- Chemical Name:
- [D-Trp8]-γ-MSH (trifluoroacetate salt)
- Synonyms
- [D-Trp8]-γ-MSH (trifluoroacetate salt);[D-Trp8]-γ-MSH (trifluoroacetate salt)
- CBNumber:
- CB515525946
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
[D-Trp8]-γ-MSH (trifluoroacetate salt) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14037 | [D-Trp8]-γ-MSH (trifluoroacetate salt) ≥95% | 1mg | $69 | 2026-04-30 | Buy | |
| Cayman Chemical | 14037 | [D-Trp8]-γ-MSH (trifluoroacetate salt) ≥95% | 5mg | $263 | 2026-04-30 | Buy | |
| Cayman Chemical | 14037 | [D-Trp8]-γ-MSH (trifluoroacetate salt) ≥95% | 10mg | $493 | 2026-04-30 | Buy | |
| Cayman Chemical | 14037 | [D-Trp8]-γ-MSH (trifluoroacetate salt) ≥95% | 25mg | $1062 | 2026-04-30 | Buy |
[D-Trp8]-γ-MSH (trifluoroacetate salt) Chemical Properties, Uses, Production
Description
[D-Trp8]-γ-MSH is a melanocortin receptor 3 (MC3R) agonist and an analog of γ-melanocyte-stimulating hormone (γ-MSH).1 It selectively induces cAMP accumulation in cells expressing MC3R over cells expressing MC4R or MC5R (EC50s = 0.33, 100, and 82 nM, respectively, for the human receptors). In vivo, [D-Trp8]-γ-MSH (162 nmol/kg, i.v.) reduces the incidence of ventricular tachycardia, ventricular fibrillation, and death in a rat model of myocardial ischemia-reperfusion injury.2 It also inhibits urate-induced chemokine (C-X-C) motif ligand 1 (CXCL1) release and peritoneal polymorphonuclear leukocyte accumulation in recessive yellow (e/e) mice with a non-functional MC1R.3WARNING This product is not for human or veterinary use.
References
[1] PAOLO GRIECO. d-Amino Acid Scan of γ-Melanocyte-Stimulating Hormone: Importance of Trp8 on Human MC3 Receptor Selectivity[J]. Journal of Medicinal Chemistry, 2000, 43 26: 4998-5002. DOI: 10.1021/jm000211e
[2] CHIARA MIONI . Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors[J]. European journal of pharmacology, 2003, 477 3: Pages 227-234. DOI: 10.1016/s0014-2999(03)02184-8
[3] STEPHEN J GETTING. [D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse).[J]. Molecular Pharmacology, 2006, 70 6: 1850-1855. DOI: 10.1124/mol.106.028878
[D-Trp8]-γ-MSH (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
[D-Trp8]-γ-MSH (trifluoroacetate salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6808 | 58 |
| Aoki Biotechnology (Shenzhen) Co., Ltd. | -- | CHINA | 6056 | 58 | |
| Neobioscience Co., Ltd. | -- | info@neobioscience.com | CHINA | 6192 | 58 |
| Supplier | Advantage |
|---|---|
| Cayman Chemical Company | 58 |
| Aoki Biotechnology (Shenzhen) Co., Ltd. | 58 |
| Neobioscience Co., Ltd. | 58 |
