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| | [D-Trp8]-γ-MSH (trifluoroacetate salt) Basic information |
| | [D-Trp8]-γ-MSH (trifluoroacetate salt) Chemical Properties |
| solubility | Water: soluble |
| | [D-Trp8]-γ-MSH (trifluoroacetate salt) Usage And Synthesis |
| Description | [D-Trp8]-γ-MSH is a melanocortin receptor 3 (MC3R) agonist and an analog of γ-melanocyte-stimulating hormone (γ-MSH).1 It selectively induces cAMP accumulation in cells expressing MC3R over cells expressing MC4R or MC5R (EC50s = 0.33, 100, and 82 nM, respectively, for the human receptors). In vivo, [D-Trp8]-γ-MSH (162 nmol/kg, i.v.) reduces the incidence of ventricular tachycardia, ventricular fibrillation, and death in a rat model of myocardial ischemia-reperfusion injury.2 It also inhibits urate-induced chemokine (C-X-C) motif ligand 1 (CXCL1) release and peritoneal polymorphonuclear leukocyte accumulation in recessive yellow (e/e) mice with a non-functional MC1R.3WARNING This product is not for human or veterinary use. | | References | [1] PAOLO GRIECO. d-Amino Acid Scan of γ-Melanocyte-Stimulating Hormone: Importance of Trp8 on Human MC3 Receptor Selectivity[J]. Journal of Medicinal Chemistry, 2000, 43 26: 4998-5002. DOI: 10.1021/jm000211e
[2] CHIARA MIONI . Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors[J]. European journal of pharmacology, 2003, 477 3: Pages 227-234. DOI: 10.1016/s0014-2999(03)02184-8
[3] STEPHEN J GETTING. [D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse).[J]. Molecular Pharmacology, 2006, 70 6: 1850-1855. DOI: 10.1124/mol.106.028878 |
| | [D-Trp8]-γ-MSH (trifluoroacetate salt) Preparation Products And Raw materials |
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