4-chloro-N-methoxy-N-methylpicolinamide
- CAS No.
- 757251-62-0
- Chemical Name:
- 4-chloro-N-methoxy-N-methylpicolinamide
- Synonyms
- 4-chloro-N-methoxy-N-methylpicolinamide;4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide;4-Chloro-N-methoxy-N-methyl-2-pyridinecarboxamide;2-Pyridinecarboxamide, 4-chloro-N-methoxy-N-methyl-
- CBNumber:
- CB51559487
- Molecular Formula:
- C8H9ClN2O2
- Molecular Weight:
- 200.62
- MDL Number:
- MFCD11975556
- MOL File:
- 757251-62-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
4-chloro-N-methoxy-N-methylpicolinamide price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | C49186 | 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide 97% | 757251-62-0 | 1g | $124 | 2026-05-06 | Buy |
| Synthonix | C49186 | 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide 97% | 757251-62-0 | 5g | $135 | 2026-05-06 | Buy |
| Synthonix | C49186 | 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide 97% | 757251-62-0 | 10g | $140 | 2026-05-06 | Buy |
| Synthonix | C49186 | 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide 97% | 757251-62-0 | 25g | $290 | 2026-05-06 | Buy |
| Ambeed | A177583 | 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide 95% | 757251-62-0 | 5g | $67 | 2026-06-05 | Buy |
4-chloro-N-methoxy-N-methylpicolinamide Chemical Properties, Uses, Production
Synthesis
5470-22-4
6638-79-5
757251-62-0
N,O-dimethylhydroxylamine hydrochloride (4.6 g, 47.61 mmol) was dissolved in DMF (50 mL) at 0 °C, followed by the addition of DIPEA (16.9 mL, 95.23 mmol) and the mixture was stirred for 10 min. Next, 4-chloropyridine-2-carboxylic acid (5.0 g, 31.74 mmol) and HATU (17.8 g, 47.61 mmol) were added and the reaction mixture was stirred for 16 hours at room temperature. After completion of the reaction, the solvent was removed by vacuum concentration and the product was purified by silica gel column chromatography using a hexane solution of 15-20% ethyl acetate as eluent to give 4-chloro-N-methoxy-N-methylpyridine-2-carboxamide (4.8 g, 96% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.37 (s, 3H), 3.72 (s, 3H), 7.35 (d, 1H), 7.63 (br s, 1H), 7.48 (d, 1H). the LCMS analysis showed a retention time of Rt = 2.30 min and a mass spectrum of m/z 201 [M + H]+ .
References
[1] Patent: WO2014/53967, 2014, A1. Location in patent: Page/Page column 151
[2] Patent: WO2015/138208, 2015, A1. Location in patent: Page/Page column 10-11
4-chloro-N-methoxy-N-methylpicolinamide Preparation Products And Raw materials
Raw materials
Preparation Products
4-chloro-N-methoxy-N-methylpicolinamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 8696 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| Changzhou Kechem Bio-Scientific Co., LTD. | 0519-68985668 13685222090 | sales@kechem.cn | China | 26012 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
