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ChemicalBook >> CAS DataBase List >>6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Structure
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one structure
CAS No.
109229-22-3
Chemical Name:
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
Synonyms
6-benzyl-5;3-d]pyriMidin-4(3H)-one;6-benzyl-3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidin-4-one;6-benzyl-1H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-4-one;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H);Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-4(3H)-one;6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyriMidin-4-one;6-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one;6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;5,6,7,8-Tetrahydro-6-(benzyl)-pyrido[4,3-d]pyrimidin-4(3H)-one
CBNumber:
CB51562360
Molecular Formula:
C14H15N3O
Molecular Weight:
241.29
MDL Number:
MFCD09835497
MOL File:
109229-22-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:43
Product description Number Pack Size Price
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one B296215 250mg $140
6-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE 95.00% CHM0391264 5MG $497.1
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one X8904 1g $318
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one X8904 5g $804
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one >95% 069990 1g $870
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6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Properties

Melting point 165-166.5 °C(Solv: acetone (67-64-1))
Boiling point 406.5±55.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 6.65±0.20(Predicted)
Appearance Light yellow to yellow Solid

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B296215 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 109229-22-3 250mg $140 2021-12-16 Buy
American Custom Chemicals Corporation CHM0391264 6-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE 95.00% 109229-22-3 5MG $497.1 2021-12-16 Buy
AK Scientific X8904 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 109229-22-3 1g $318 2021-12-16 Buy
AK Scientific X8904 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 109229-22-3 5g $804 2021-12-16 Buy
Matrix Scientific 069990 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one >95% 109229-22-3 1g $870 2021-12-16 Buy
Product number Packaging Price Buy
B296215 250mg $140 Buy
CHM0391264 5MG $497.1 Buy
X8904 1g $318 Buy
X8904 5g $804 Buy
069990 1g $870 Buy

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Chemical Properties,Uses,Production

Uses

6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one is used in the discovery/optimization of quinazolinones as new P2X3 receptor antagonists.

Uses

6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one is used in the discovery/optimization of quinazolinones as new P2X3 receptor antagonists.

Synthesis

Formamidine acetate

3473-63-0

Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride

1454-53-1

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

109229-22-3

1. in a 350 mL sealed reactor, ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (50.0 g, 0.168 mol), formamidine acetate (16.2 g, 0.201 mol), a methanolic solution of 4.37 M sodium methanolate (190 mL), and methanol (200 mL) were mixed. 2. the reaction mixture was heated to 85 °C and maintained for 16 hours. 3. Upon completion of the reaction, the mixture was cooled and concentrated under reduced pressure.4. The concentrated residue was dissolved in 1 N NaOH solution (150 mL), which was subsequently poured into ice water.5. The pH of the mixture was adjusted to 7 by slow addition of glacial acetic acid, and a tan solid precipitated.6. The solid was collected by filtration, and washed sequentially with water and cold ethyl ether.7. It was dried under high vacuum to afford 6-benzyl-5,6,7,8-tetrahydropyridine and [4,3-d]pyrimidin-4(3H)-one as a brown solid (26.2 g, 61.4% yield). 8. Mass spectrometry showed [M + H]+ = 242.2. 9. 1H NMR (DMSO-d6) δ: 2.29 (t, J = 5.8 Hz, 2H), 2.61 (t, J = 5.8 Hz, 2H), 3.26 (s, 2H), 3.64 (s, 2H), 3.65 (s, 2H), 3.66 (s, 2H), 3.67 (s, 2H), 3.67 (s, 2H). 3.64 (s, 2H), 7.21-7.36 (m, 6H), 7.96 (s, 1H).

References

[1] Patent: US2006/258689, 2006, A1. Location in patent: Page/Page column 22; 23; 27; 28
[2] Patent: US2008/275037, 2008, A1. Location in patent: Page/Page column 22
[3] Patent: WO2008/123963, 2008, A1. Location in patent: Page/Page column 44
[4] Patent: WO2011/103715, 2011, A1. Location in patent: Page/Page column 38
[5] Patent: WO2011/106276, 2011, A1. Location in patent: Page/Page column 38

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Preparation Products And Raw materials

Raw materials

Formamidine acetate 1-Benzyl-3-ethoxycarbonyl-4-piperidone Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride Sodium Methoxide Sodium hydroxide
Acetic acid

1of2

Preparation Products

TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49976 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29798 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10237 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		+86-029-86185165 +8618629664246 guoyuan@eastchinapharm.com China 1615 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58

View Lastest Price from 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one pictures 2020-01-13 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
109229-22-3
 US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Spectrum

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one(109229-22-3)1HNMR

109229-22-3(6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one)Related Search:

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6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 6-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one 3-d]pyriMidin-4(3H)-one 6-benzyl-5 6-benzyl-3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidin-4-one 6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyriMidin-4-one Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-4(3H)-one 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H) 6-benzyl-1H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-4-one 6-(phenylmethyl)-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one Pyrido[4,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-6-(phenylmethyl)- 5,6,7,8-Tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4(3H)-one 5,6,7,8-Tetrahydro-6-(benzyl)-pyrido[4,3-d]pyrimidin-4(3H)-one 109229-22-3 CHIRAL CHEMICALS