Description
Histone H2A is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to a variety of post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, which function as epigenetic regulators of transcription.2,1 Histone H2A contains a C-terminal tail that, in contrast to other core histones, also extends outside of the nucleosome core and is highly variable, yielding a number of H2A variants that are subject to PTMs and differentially regulate nucleosome stability and chromatin structure.3 Serum histone H2A autoantibodies have been found in patients with drug-induced or spontaneous systemic lupus erythematosus (SLE).4 Cayman's Histone H2A (C-Term) Monoclonal Antibody (Clone RM225) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications. This antibody recognizes the C-terminal region of histone H2A independent of PTMs.WARNING This product is not for human or veterinary use.
