Description
Histone H2A.Z is a variant of histone H2A, a nuclear protein and a component of the nucleosome core.1,2 It is a globular protein containing unstructured N- and C-terminal tails that extend outside of the nucleosome core that are subject to a variety of post-translational modifications (PTMs), including acetylation, methylation, and ubiquitination, which function as epigenetic regulators of transcription.3 Histone H2A.Z influences chromatin accessibility and nucleosome stability, regulating various cellular functions, including DNA replication and repair, mitosis, heterochromatin formation, and chromosome segregation.1,4 It is enriched at gene promoters and associated with active or repressed gene transcription in a manner dependent on species or PTMs, among other factors.5,4 Increased tumor H2A.Z levels are associated with decreased overall survival in patients with breast cancer.6 Cayman's Histone H2A.Z (C-Term) Monoclonal Antibody (Clone RM215) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications. The antibody recognizes the C-terminal region of histone H2A.Z independent of PTMs.WARNING This product is not for human or veterinary use.
