Description
7-Deazaadenosine-5'-O-triphosphate is a modified nucleotide and an active metabolite of the nucleoside analog tubercidin (Item No. 35834).1 It is incorporated into the DNA of mouse L-cells using DNA polymerase α but not into the RNA of E. coli using RNA-dependent RNA polymerases (RdRps).1,2 7-Deazaadenosine-5'-O-triphosphate has been used as a probe for the ATP binding site of protein kinase A (PKA).3WARNING This product is not for human or veterinary use.
References
[1] G SEIBERT. Tubercidin metabolism in mouse L5178y cells in vivo and in vitro.[J]. Gan, 1978, 69 6: 739-747.
[2] SUSUMU NISHIMURA Morio I Fumio Harada. The selective utilization of tubercidin triphosphate as an ATP analog in the DNA-dependent RNA polymerase system[J]. Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966, 129 2: Pages 301-309. DOI: 10.1016/0005-2787(66)90372-8
[3] JÜRGEN HOPPE. Mapping the ATP-Binding Site in the Catalytic Subunit of A denosine-3′:5′-monophosphate-Dependent Protein Kinase[J]. The FEBS journal, 1978, 90 3: 427-432. DOI: 10.1111/j.1432-1033.1978.tb12621.x
