HUMAN RANTES
- CAS No.
- 1927910-48-2
- Chemical Name:
- HUMAN RANTES
- Synonyms
- CCL8;HC14;MCP-2;SCYA8;SCYA10;RHRANTES;HUMAN CCL5;MCP-2, HUMAN;HUMAN RANTES;RANTES, HUMAN
- CBNumber:
- CB5157790
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00213042
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard Codes | T,Xn,F |
|---|---|
| Risk Statements | 23/24/25-36/37/38-36-20/21/22-11 |
| Safety Statements | 26-36/37/39-45-36/37-16 |
| WGK Germany | 3 |
| Storage Class | 10 - Combustible liquids |
HUMAN RANTES price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3269 | RANTES human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) | 20 μg | $485 | 2026-04-30 | Buy | |
| Biosynth | BL10005_R | Recombinant Human RANTES | 0.01mg | $556.88 | 2026-06-04 | Buy | |
| Biosynth | BL10005_R | Recombinant Human RANTES | 0.05mg | $1116.5 | 2026-06-04 | Buy | |
| Biorbyt Ltd | orb1909738 | Human CCL8 Protein, His Tag 90% | 100μg | $750 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb1909738 | Human CCL8 Protein, His Tag 90% | 1mg | $4060 | 2026-05-06 | Buy |
HUMAN RANTES Chemical Properties,Uses,Production
Uses
RANTES human has been used in following studies:
- In transmigration experiments to determine whether LFA-1 cross-linking could affect peripheral blood T lymphocytes (PBTL) migration in response to the chemokine RANTES.
- Luminol-dependent chemiluminescence assay to determine the effect of RANTES on reactive oxygen species (ROS) production by eosinophils.
Biological Activity
Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5.1 RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. The In1.1C variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV-1 infection.
Description
Monocyte Chemotactic Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8904 Dalton.
The MCP2 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. Rantes has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-g) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. Rantes is also an HIV-suppressive factor released from CD8+ T cells. The Rantes chemokine has been localized to chromosome 17 in humans.
HUMAN RANTES Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN RANTES Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 29717 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
