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| Product Name: | HUMAN RANTES | | Synonyms: | HUMAN SIS-DELTA;HUMAN MCP2 (CCL8);HUMAN MCP2 (CCL8) CHEMICALLY SYNTHESIZED CHEMOKINE;HUMAN CCL5;REC RANTES (HUMAN);RECOMBINANT HUMAN RANTES;RHRANTES;RANTES [HOMO SAPIENS] | | CAS: | 1927910-48-2 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN RANTES Structure]() |
| | HUMAN RANTES Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | color | white | | biological source | mouse |
| | HUMAN RANTES Usage And Synthesis |
| Uses | RANTES human has been used in following studies:
- In transmigration experiments to determine whether LFA-1 cross-linking could affect peripheral blood T lymphocytes (PBTL) migration in response to the chemokine RANTES.
- Luminol-dependent chemiluminescence assay to determine the effect of RANTES on reactive oxygen species (ROS) production by eosinophils.
| | Biological Activity | Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5.1 RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. The In1.1C variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV-1 infection. | | Description | Monocyte Chemotactic Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8904 Dalton.
The MCP2 is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. Rantes has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-g) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. Rantes is also an HIV-suppressive factor released from CD8+ T cells. The Rantes chemokine has been localized to chromosome 17 in humans. |
| | HUMAN RANTES Preparation Products And Raw materials |
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