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Boc-L-beta-Homoproline

Boc-L-beta-Homoproline structure

CAS No.: 56502-01-3

Chemical Name:: Boc-L-beta-Homoproline

Synonyms: Boc-b-HoPro-OH;Boc-β-HoPro-OH;BOC-BETA-HPRO-OH;Boc-β-HomoPro-OH;Boc-p-HomoPro-OH;BOC-BETA-HOPRO-OH;BOC-BETA3-HOMOPRO;BOC-PRO-(C*CH2)OH;boc-β3-homopro-oh;BOC-B-HOMOPROLINE

CBNumber:: CB5169171

Molecular Formula:: C11H19NO4

Molecular Weight:: 229.27

MDL Number:: MFCD01862939

MOL File:: 56502-01-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:00

Product description	Number	Pack Size	Price
Boc-β3-Homopro-OH ≥98.0% (TLC)	14982	1g	$85
BOC-L-BETA-HOMOPROLINE 97%	56180	1G	$82
BOC-L-BETA-HOMOPROLINE 97%	56180	5G	$250
BOC-L-BETA-HOMOPROLINE 97%	56180	10G	$480
(S)-2-(1-Boc-2-pyrrolidinyl)acetic Acid 95%	B8970	100mg	$22
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Boc-L-beta-Homoproline Properties

Melting point	98 °C
Boiling point	357.4±15.0 °C(Predicted)
Density	1.151±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.56±0.10(Predicted)
form	Crystalline Powder
color	White to off-white
BRN	478306
Major Application	peptide synthesis
InChI	InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(12)7-9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1
InChIKey	GDWKIRLZWQQMIE-QMMMGPOBSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC[C@H]1CC(O)=O
CAS DataBase Reference	56502-01-3(CAS DataBase Reference)
UNSPSC Code	12352202
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H319-H315

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

Boc-L-beta-Homoproline price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	14982	Boc-β3-Homopro-OH ≥98.0% (TLC)	56502-01-3	1g	$85	2023-06-20	Buy
AstaTech	56180	BOC-L-BETA-HOMOPROLINE 97%	56502-01-3	1G	$82	2026-04-30	Buy
AstaTech	56180	BOC-L-BETA-HOMOPROLINE 97%	56502-01-3	5G	$250	2026-04-30	Buy
AstaTech	56180	BOC-L-BETA-HOMOPROLINE 97%	56502-01-3	10G	$480	2026-04-30	Buy
Synthonix	B8970	(S)-2-(1-Boc-2-pyrrolidinyl)acetic Acid 95%	56502-01-3	100mg	$22	2026-05-06	Buy

Product number	Packaging	Price	Buy
14982	1g	$85	Buy
56180	1G	$82	Buy
56180	5G	$250	Buy
56180	10G	$480	Buy
B8970	100mg	$22	Buy

Boc-L-beta-Homoproline Chemical Properties,Uses,Production

Uses

Building block for necine alkaloids.

Uses

Boc-L-beta-homoproline is an amino acid derivative which is a reagent in the synthesis of dihydroisoxazole inhbitors of human transglutaminase 2, an enzyme that catalyzes the modification of glutamine residues. This enzyme has been implicated in numerous inflmmatory, fibrotic and other diseases.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

88790-37-8

56502-01-3

General procedure for the synthesis of (S)-2-(2-pyrrolidinyl)acetic acid from methyl (S)-2-(2-pyrrolidinyl)acetate: tert-butyl (2S)-2-(2-methoxy-2-oxoethyl)-1-pyrrolidinecarboxylate (8.35 g, 34.3 mmol) was dissolved in 150 mL of methanol. 50 mL of 1 M aqueous sodium hydroxide solution was added and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solution was concentrated under reduced pressure to about 100 mL. The concentrated solution was added to 300 mL of water and extracted twice with ether (2 x 100 mL). The aqueous phase was acidified to pH 2 with 12N hydrochloric acid and extracted with ether twice more (2 x 100 mL). The aqueous layer was saturated with saturated sodium chloride solution and then extracted with ether a third time (100 mL). All organic layers were combined, washed sequentially with water and saturated sodium chloride solution, and then dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the title compound (S)-2-(1-tert-butoxycarbonyl-2-pyrrolidinyl)acetic acid as a white solid (7.28 g, 31.7 mmol, 92.6% yield). peaks, 4H), 1.48 (single peak, 9H) ppm.

References

[1] Patent: WO2003/76440, 2003, A1. Location in patent: Page/Page column 140
[2] Journal of Organic Chemistry, 2005, vol. 70, # 22, p. 8730 - 8733
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 22, p. 3977 - 3988
[4] Tetrahedron Letters, 1997, vol. 38, # 20, p. 3609 - 3610

Boc-L-beta-Homoproline Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Triethylamine BOC-L-Prolinol Tosyl chloride Dichloromethane

POTASSIUM CYANIDE 4-Dimethylaminopyridine Boc-pyrrolidin-2-yl-acetic acid ethyl ester BOC-D-BETA-HOMOPROLINE (S)-1-Boc-2-(2-hydroxyethyl)pyrrolidine

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Preparation Products

Boc-L-beta-Homoproline Suppliers

Global( 195)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29817	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
GenicBio Limited	58
career henan chemical co	58
Accela ChemBio Inc.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58

View Lastest Price from Boc-L-beta-Homoproline manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	Boc-L-beta-Homoproline 56502-01-3	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2019-07-06	Boc-L-beta-Homoproline 56502-01-3	US $1.00 / kg	1kg	98%	100KG	Career Henan Chemical Co

Boc-L-beta-Homoproline
56502-01-3
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Boc-L-beta-Homoproline
56502-01-3
US $1.00 / kg
98%
Career Henan Chemical Co

Boc-L-beta-Homoproline Spectrum

Boc-L-beta-Homoproline(56502-01-3)¹HNMR

56502-01-3(Boc-L-beta-Homoproline)Related Search:

L-PROLINE-(4-3H(N)) Povidone iodine Ethyl 2-(Chlorosulfonyl)acetate cis-4-Hydroxy-L-proline BOC-L-Proline

N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone tert-Butanol Polyvinylpyrrolidone Ascoric Acid

BOC-D-BETA-HOMOPROLINE Acetic anhydride Phenylacetic acid METHYL-2-PYRROLIDONE Carbonyl iron powder

3-TERT-BUTOXYCARBONYLAMINO-HEXANOIC ACID (S)-(1-Boc-5-oxo-pyrrolidin-2-yl)acetic acid (S)-2-(2-PYRROLIDINYL)ACETIC ACID

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N-BOC-(2S)-PYRR(2-CHCOOH) N-BETA-T-BUTOXYCARBONYL-L-BETA-HOMOPROLINE (S)-2-(1-BOC-2-PYRROLIDINYL)ACETIC ACID (S)-N-T-BUTOXYCARBONYL-PYRROLIDINE-2-ACETIC ACID BOC-L-BETA-HOMOPROLINE BOC-BETA3-HOMOPRO BOC-BETA-HOPRO-OH BOC-BETA-HOMOPROLINE BOC-BETA-HOMOPRO-OH BOC-PRO-(C*CH2)OH Boc-L-beta(3)-homoproline Boc-L-b-homoproline boc-β3-homopro-oh BOC-B-HOMOPROLINE Boc-L-β-Homo-Pro-OH Boc-L-beta-HPro-OH N-beta-(t-Butyloxycarbonyl)-L-homoproline, (S)-N-t-Butyloxycarbonyl-2-(pyrrolidin-2-yl)acetic acid Boc-b-HoPro-OH 2-[(2S)-(1-tert-Butoxycarbonyl)pyrrolidin-2-yl]acetic acid (S)-2-(1-Boc-2-pyrrolidinyl)acetic acid, Boc-L-β3-homoproline Boc-beta-HoPro-OH 56502- Boc-L-β-homoproline≥ 98% (NMR) 2-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic acid BOC-BETA-HPRO-OH (S)-2-(carboxymethyl)pyrrolidinium chloride Boc-L-beta-homo-Pro (S)-2-Carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Boc-L-β-homoproline ,98% (S)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)acetic acid 2-Pyrrolidineacetic acid, 1-[(1,1-diMethylethoxy)carbonyl]-, (2S)- (S)-N-t-Butyloxycarbonyl-2-(pyrrolidin-2-yl)acetic acid N-beta-(t-Butyloxycarbonyl)-L-homoproline Boc-β-HomoPro-OH Boc-beta3-Homopro-OH Boc-L-β-Homoproline Boc-p-HomoPro-OH Boc-L-beta-Homoproline USP/EP/BP Boc-β-HoPro-OH (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine Boc-β³-Homopro-OH (S)-2-(1-Bocpyrrolidin-2-yl)-acetic acid 56502-01-3 C11H19N1O4 Specialty Synthesis Peptide Synthesis Unnatural Amino Acid Derivatives Beta-Amino Acids β-Homo Amino Acids Beta amino acids