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BOC-L-Proline

BOC-L-Proline structure

CAS No.: 15761-39-4

Chemical Name:: BOC-L-Proline

Synonyms: BOC-PRO-OH;(tert-butoxycarbonyl)-L-proline;BOC-PRO;N-BOC-L-PROLINE;(tert-butoxycarbonyl)proline;BOC-L-PRO;BOC-L-PRO-OH;N-BOC-PROLINE;N-(TERT-BUTOXYCARBONYL)-L-PROLINE;(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid

CBNumber:: CB3274189

Molecular Formula:: C10H17NO4

Molecular Weight:: 215.25

MDL Number:: MFCD00037324

MOL File:: 15761-39-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:11:47

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BOC-L-Proline Properties

Melting point	133-135 °C(lit.)
alpha	-60.5 º (c=1, HAc)
Boiling point	355.52°C (rough estimate)
Density	1.1835 (rough estimate)
refractive index	-60 ° (C=2, AcOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in acetic acid.
pka	4.01±0.20(Predicted)
form	Crystals or Crystalline Powder
color	White
optical activity	[α]20/D 61±2°, c = 2% in acetic acid
BRN	15828
Major Application	peptide synthesis
InChI	1S/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
InChIKey	ZQEBQGAAWMOMAI-ZETCQYMHSA-N
SMILES	CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O
CAS DataBase Reference	15761-39-4(CAS DataBase Reference)
EPA Substance Registry System	1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

TSCA listed

HS Code

2933 99 80

HazardClass

IRRITANT

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

BOC-L-Proline price More Price(105)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53003	Boc-Pro-OH Novabiochem?	15761-39-4	25g	$61.4	2026-04-30	Buy
Sigma-Aldrich	15490	Boc-Pro-OH ≥99.0% (T)	15761-39-4	5g	$40	2026-04-30	Buy
Sigma-Aldrich	8.53003	Boc-Pro-OH Novabiochem?	15761-39-4	100g	$141	2026-04-30	Buy
TCI Chemical	B1188	N-(tert-Butoxycarbonyl)-L-proline >99.0%(T)	15761-39-4	5g	$19	2026-04-30	Buy
TCI Chemical	B1188	N-(tert-Butoxycarbonyl)-L-proline >99.0%(T)	15761-39-4	25g	$55	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.53003	25g	$61.4	Buy
15490	5g	$40	Buy
8.53003	100g	$141	Buy
B1188	5g	$19	Buy
B1188	25g	$55	Buy

BOC-L-Proline Chemical Properties, Uses, Production

Description

N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

Chemical Properties

White to off-white microcrystalline powder

Uses

N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

Preparation

Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

References

[1] ALBRECHT BERKESSEL Johann L Burkhard Koch. Proline-Derived N-Sulfonylcarboxamides: Readily Available, Highly Enantioselective and Versatile Catalysts for Direct Aldol Reactions[J]. Advanced Synthesis & Catalysis, 2004, 346 9-10: 1141-1146. DOI: 10.1002/adsc.200404126
[2] JUNXING SHI . Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 10: Pages 3488-3491. DOI: 10.1016/j.bmcl.2012.03.089

BOC-L-Proline Preparation Products And Raw materials

Raw materials

Preparation Products

L-Proline benzyl ester hydrochloride D-1-N-Boc-prolinamide N-Boc prrolidin-2-ol Semax ANGIOTENSIN I, HUMAN

2-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Cetrorelix Boc-L-Proline-methyl ester ANGIOTENSIN II, HUMAN (S)-tert-butyl 2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate

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BOC-L-Proline Suppliers

Global Suppliers ( 745)

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Shanghai Chiral Chemicals Inc.	021-37285021 13472570865	tym7xi@aliyun.com	China	299	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
GenChem & GenPharm (Changzhou) Co., Ltd.	0519-85720003 18861157602	410649415@qq.com	China	111	58
Shouguang Jiasheng Chemical Co., Ltd.	0536-7971999 13583611556	sgjiasheng@hotmail.com	China	300	58
Nanjing Yihua Biotechnology Co., Ltd	13429882898; 13429882898	1096323105@qq.com	China	291	58
Hubei Jingxiang Technology Co., Ltd.	18136494513 13347833233	549483679@qq.com	China	21	58
Shanxi Nuocheng Biotechnology Co., Ltd	17835231871	572710841@qq.com	China	7931	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Shanghai Chiral Chemicals Inc.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Hobor Chemical Co., Ltd	60
GenChem & GenPharm (Changzhou) Co., Ltd.	58
Shouguang Jiasheng Chemical Co., Ltd.	58
Nanjing Yihua Biotechnology Co., Ltd	58
Hubei Jingxiang Technology Co., Ltd.	58
Shanxi Nuocheng Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76

View Latest Price from BOC-L-Proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	BOC-L-Proline 15761-39-4		1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	Boc-L-Proline 15761-39-4	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-07-30	BOC-L-Proline 15761-39-4	$200.00	1KG	98%	20TONS	Anhui Dexinjia Biopharm Co., Ltd

BOC-L-Proline
15761-39-4
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-L-Proline
15761-39-4
$5.00
99%
Henan Fengda Chemical Co., Ltd

BOC-L-Proline
15761-39-4
$200.00
98%
Anhui Dexinjia Biopharm Co., Ltd

BOC-L-Proline Spectrum

BOC-L-Proline(15761-39-4)MS BOC-L-Proline(15761-39-4)¹HNMR BOC-L-Proline(15761-39-4)IR1 BOC-L-Proline(15761-39-4)IR2 BOC-L-Proline(15761-39-4)Raman

15761-39-4 (BOC-L-Proline) Related Search:

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N-Boc-L-valine L-Proline BOC-L-PROLINE AMIDE tert-Butanol Butyl oleate

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BOC-L-PROLINE-OH L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid L-PROLINE-N-T-BOC BOC-L-Proline, 99+% 25GR (S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid N-Boc-L-Proline N-Boc-L-proline Boc-Pro-OH N-(tert-Butoxycarbonyl)-L-proline N-(tert-Butoxycarbonyl)-L-proline (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester The BOC-L- pro N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T) Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline Boc-Pro-OH >=99.0% (T) Daclatasvir Intermediates 3 1-tert-Butyloxycarbonyl-L-proline (S)-Boc-pyrrolidine-2-carboxylic acid Boc-L-proline≥ 98% (HPLC) TBOC-L-PROLINE T-BUTYLOXYCARBONYL-L-PROLINE RARECHEM AL BO 1463 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)- 1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate BOC-L-Proline, 99+% Boc-DL-Proline-OH TERT-BUTYLOXYCARBONYLPROLINE N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE Boc-Pro-OH (Boc-L-Proline N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Butoxycarbonylproilne N-(tert-Butoxycarbonyl)-L-proline ,98.5% (2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid (2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline) (2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester N-(TERT-BUTOXYCARBONYL)-L-PROILNE N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE N-T-BUTOXYCARBONYL-L-PROLINE N-T-BOC-L-PROLINE n-alpha-tert-boc-l-proline N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE N-ALPHA-T-BOC-L-PROLINE BOC-L-PROLINE extrapure 1-Tert-Butoxycarbonyl-L-proline Boc-L-proline ,98.5% BOC-PYRD(2)-OH BOC-PROLINE BOC-L-PROLINE (Tert-Butoxy)Carbonyl Pro-OH 1-(1,1-dimethylethyl)ester,(s)-2-pyrrolidinedicarboxylicacid N-(tert-Butoxycarbonyl)-L-proline> BOC-L-Proline USP/EP/BP N-(tert-butoxycarbonyl)-laevo-proline Pentanoicacid,2,9-dioxo-,methylester N-tert-Boc-L-Proline