N4-Acetylcytosine
- CAS No.
- 14631-20-0
- Chemical Name:
- N4-Acetylcytosine
- Synonyms
- N-(2-Oxo-1,2-dihydropyriMidin-4-yl)acetaMide;N-ACETYLCYTOSINE;4-Acetylamino-2-hydroxypyrimidine;N4-AcetyL;N-Acetocytosine;N-Actyl cytosine;N4-ACETYLCYTOSINE;N’-4-Acetyl cytosine;N4-Acetylcytosine 99%;N4-Acetylcytosine >
- CBNumber:
- CB5174391
- Molecular Formula:
- C6H7N3O2
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00134466
- MOL File:
- 14631-20-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C (lit.) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Very Slightly) |
| form | Solid |
| pka | 7.60±0.10(Predicted) |
| color | Off-White to Pale Beige |
| BRN | 138451 |
| InChI | InChI=1S/C6H7N3O2/c1-4(10)8-5-2-3-7-6(11)9-5/h2-3H,1H3,(H2,7,8,9,10,11) |
| InChIKey | IJCKBIINTQEGLY-UHFFFAOYSA-N |
| SMILES | C(NC1=CC=NC(=O)N1)(=O)C |
| CAS DataBase Reference | 14631-20-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
N4-Acetylcytosine price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 377910 | N4-Acetylcytosine 99% | 14631-20-0 | 25g | $103 | 2026-04-30 | Buy |
| TCI Chemical | A2089 | N4-Acetylcytosine >98.0%(T) | 14631-20-0 | 5g | $27 | 2026-04-30 | Buy |
| TCI Chemical | A2089 | N4-Acetylcytosine >98.0%(T) | 14631-20-0 | 25g | $90 | 2026-04-30 | Buy |
| Usbiological | 258289 | N4-Acetylcytosine Asreported | 14631-20-0 | 50g | $323 | 2026-06-03 | Buy |
| Usbiological | 258289 | N4-Acetylcytosine Asreported | 14631-20-0 | 100g | $439 | 2026-06-03 | Buy |
N4-Acetylcytosine Chemical Properties, Uses, Production
Synthesis
Acetic anhydride (2.1 mL, 22.05 mmol) was added to a solution of cytosine (500 mg) in pyridine (2.5 mL) under stirring. The mixture was stirred overnight at room temperature. The mixture was diluted with EtOAc (2.0 mL), and stirred again at room temperature for 30 minutes. The resulting white solid was filtered off, washed with EtOAc, and then dried under vacuum to obtain the product N4-acetylcytosine.
Chemical Properties
Crstalline powder
Uses
N4-Acetylcytosine may be used in the preparation of cytidine. It may be used in the preparation of 1-(4-azido-4-deoxy-β-D-glucopyranosyl)cytosine.
Definition
ChEBI: N(4)-acetylcytosine is a pyrimidone that is cytosine bearing an N(4)-acetyl substituent. It is a pyrimidone, a nucleobase analogue and a member of acetamides. It is functionally related to a cytosine.
General Description
Four stable conformers of N4-acetylcytosine, and the one of the stable form containing an intramoleuclar six-membered ring have been reported by theoretical calculations.The infrared and FT-Raman spectra of N4-acetylcytosine in the solid phase has been reported.
Purification Methods
If TLC or paper chromatography shows that it contains unacetylated cytosine, then reflux it in Ac2O for 4hours, cool at 3-4o for a few days, collect the crystals, wash them with cold H2O, then EtOH and dry at 100o. It is insoluble in EtOH and dissolves in H2O with difficulty, but crystallises in prisms from hot H2O. It is hydrolysed by 80% aqueous AcOH at 100o/1hour. [UV: Brown et al. J Chem Soc 2384 1956, Codington et al. J Am Chem Soc 80 5164 1958.] It forms an Hg salt [Fox et al. J Am Chem Soc 79 5060 1957]. [Beilstein 25 III/IV 3657.]
N4-Acetylcytosine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Yuanmeng Biotechnology Co., Ltd | 027-68897569 18120462897 | fiona@yuanmengbio.com | China | 4653 | 58 |
| Shanghai Peiling Biological Technology Co., LTD | 13127581762 13127581762 | peilingchem@sina.com | China | 494 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from N4-Acetylcytosine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | N4-Acetylcytosine
14631-20-0
|
1Kg | 98% | 20Tons | Xinxiang Aurora Biotechnology Co.,Ltd. | ||
 |
2026-09-18 | N4-Acetylcytosine
14631-20-0
|
1KG | 99%min HPLC | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-07 | N4-Acetylcytosine
14631-20-0
|
1kg | 99%min | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. |
-
- N4-Acetylcytosine
14631-20-0
- $0.00
- 98%
- Xinxiang Aurora Biotechnology Co.,Ltd.
-
- N4-Acetylcytosine
14631-20-0
- $0.00
- 99%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- N4-Acetylcytosine
14631-20-0
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
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