Isoquinoline-4-carbonitrile
- CAS No.
- 34846-65-6
- Chemical Name:
- Isoquinoline-4-carbonitrile
- Synonyms
- ine-4-carbonitriL;4-Cyanoisoquinoline;4-Isoquinolinecarbonitrile;Isoquinoline-4-carbonitrile;4-Cyanoisoquinoline, 4-Cyano-2-azanaphthalene;ISOQUINOLINE-4-CARBONITRILE ISO 9001：2015 REACH
- CBNumber:
- CB5204920
- Molecular Formula:
- C10H6N2
- Molecular Weight:
- 154.17
- MDL Number:
- MFCD00957039
- MOL File:
- 34846-65-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 104 °C |
|---|---|
| Boiling point | 329.1±15.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 1.96±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C10H6N2/c11-5-9-7-12-6-8-3-1-2-4-10(8)9/h1-4,6-7H |
| InChIKey | NPDZTCFGRSYTPF-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=CC=C2)C(C#N)=CN=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P312-P260-P280 |
| HS Code | 2933499090 |
Isoquinoline-4-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | AB1208 | 4-CYANO-ISOQUINILINE 95% | 34846-65-6 | 1G | $55 | 2026-04-30 | Buy |
| AstaTech | AB1208 | 4-CYANO-ISOQUINILINE 95% | 34846-65-6 | 5G | $165 | 2026-04-30 | Buy |
| Apolloscientific | OR48030 | Isoquinoline-4-carbonitrile ≥95% | 34846-65-6 | 250mg | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS1289 | 4-Cyanoisoquinoline 95% | 34846-65-6 | 1g | $50 | 2026-06-04 | Buy |
| Activate Scientific | AS1289 | 4-Cyanoisoquinoline 95% | 34846-65-6 | 5g | $124 | 2026-06-04 | Buy |
Isoquinoline-4-carbonitrile Chemical Properties,Uses,Production
Synthesis
557-21-1
34784-02-6
34846-65-6
To a stirred solution of 3-bromoisoquinoline (Intermediate-12) (9.2 g, 44.2 mmol) in N,N-dimethylformamide (DMF) (15 mL) was sequentially added tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (10.2 g, 8.84 mmol) and zinc cyanide (Zn(CN)2) (10.34 g, 88.44 mmol. 2.0 equiv). The reaction system was degassed with nitrogen (N2) for 20 min to exclude oxygen. Subsequently, the reaction mixture was heated to 120 °C and the reaction was stirred at this temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. Insoluble impurities were removed by filtration and the filtrate was concentrated under reduced pressure to remove solvent. The resulting crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford the target compound 4-cyanoisoquinoline (3.4 g, 27.4% yield) as a pale yellow solid.
References
[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0220
Isoquinoline-4-carbonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou bayaoke Biotechnology Co., Ltd | 18626188356 | 1058187422@qq.com | China | 510 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from Isoquinoline-4-carbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | ISOQUINOLINE-4-CARBONITRILE
34846-65-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-01-15 | ISOQUINOLINE-4-CARBONITRILE
34846-65-6
|
$2.00 | 1g | 98%MIN | Career Henan Chemical Co |
-
- ISOQUINOLINE-4-CARBONITRILE
34846-65-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- ISOQUINOLINE-4-CARBONITRILE
34846-65-6
- $2.00
- 98%MIN
- Career Henan Chemical Co
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