Homogentisic acid
- CAS No.
- 451-13-8
- Chemical Name:
- Homogentisic acid
- Synonyms
- 2,5-DIHYDROXYPHENYLACETIC ACID;2-(2,5-dihydroxyphenyl)acetic acid;alcapton;Melanic acid;homogentisicaci;Homogentisic acid;Homogentisinic acid;HOMOGENTISIC ACID(RG);Homogentisic Acid >Homogentisic Acid, ≥ 97.0%
- CBNumber:
- CB5207860
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00004324
- MOL File:
- 451-13-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 150-152 °C (lit.) |
|---|---|
| Boiling point | 257.07°C (rough estimate) |
| Density | 1.3037 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in methanol. |
| pka | 4.4(at 25℃) |
| form | crystalline |
| color | off-white to tan |
| Water Solubility | very faint turbidity |
| Merck | 14,4737 |
| BRN | 2692860 |
| Major Application | food and beverages |
| InChI | 1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12) |
| InChIKey | IGMNYECMUMZDDF-UHFFFAOYSA-N |
| SMILES | OC(=O)Cc1cc(O)ccc1O |
| LogP | 0.860 |
| CAS DataBase Reference | 451-13-8(CAS DataBase Reference) |
| FDA UNII | NP8UE6VF08 |
| EPA Substance Registry System | Benzeneacetic acid, 2,5-dihydroxy- (451-13-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AH0589000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29182900 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
Homogentisic acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H0751 | Homogentisic acid crystalline | 451-13-8 | 100mg | $153 | 2026-04-30 | Buy |
| Sigma-Aldrich | H0751 | Homogentisic acid crystalline | 451-13-8 | 500mg | $385 | 2026-04-30 | Buy |
| Sigma-Aldrich | 92168 | Homogentisic acid analytical standard | 451-13-8 | 25MG | $126 | 2022-05-15 | Buy |
| TCI Chemical | D1050 | Homogentisic Acid >97.0%(HPLC)(T) | 451-13-8 | 1g | $210 | 2026-04-30 | Buy |
| TCI Chemical | D1050 | Homogentisic Acid >97.0%(HPLC)(T) | 451-13-8 | 5g | $674 | 2026-04-30 | Buy |
Homogentisic acid Chemical Properties, Uses, Production
Chemical Properties
off-white to tan crystals or crystalline powder
Uses
An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.
Uses
Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
- Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
- Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).
It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).
Definition
ChEBI: Homogentisic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions. It has a role as a human metabolite and a plant metabolite. It is a dihydroxyphenylacetic acid and a member of hydroquinones. It is functionally related to a phenylacetic acid. It is a conjugate acid of a homogentisate.
General Description
Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.
Purification Methods
Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]
Homogentisic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from Homogentisic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | HOMOGENTISIC ACID
451-13-8
|
$12.00-25.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-14 | HOMOGENTISIC ACID
451-13-8
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- HOMOGENTISIC ACID
451-13-8
- $12.00-25.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- HOMOGENTISIC ACID
451-13-8
- $8.80
- 97%-99%
- Career Henan Chemical Co
451-13-8 (Homogentisic acid) Related Search:
1of4
