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Sodium 4-phenylbutyrate

Sodium 4-phenylbutyrate Structure
Sodium 4-phenylbutyrate structure
CAS No.
1716-12-7
Chemical Name:
Sodium 4-phenylbutyrate
Synonyms
SODIUM PHENYLBUTYRATE;PBNA;4PBA;Tributyrate;4-PHENYLBUTYRATE;Ammonaps;Nsc657802;4PBA SODIUM;4-PHENYLBUTYRATE, NA;Sodium 4-Phenylbutyr
CBNumber:
CB5213148
Molecular Formula:
C10H13NaO2
Molecular Weight:
188.2
MDL Number:
MFCD00800247
MOL File:
1716-12-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-20 20:20:01
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Sodium 4-phenylbutyrate Properties

Melting point 224-226°C (dec.)
storage temp. room temp
solubility H2O: ≥5mg/mL
form White to slightly yellow solid
color white to beige
Water Solubility water: 10mg/mL
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
InChI InChI=1S/C10H12O2.Na.H/c11-10(12)8-4-7-9-5-2-1-3-6-9;;/h1-3,5-6H,4,7-8H2,(H,11,12);;
InChIKey OBKXEAXTFZPCHS-UHFFFAOYSA-N
SMILES C(C1C=CC=CC=1)CCC(=O)O.[NaH]
CAS DataBase Reference 1716-12-7(CAS DataBase Reference)
FDA UNII NT6K61736T
NCI Drug Dictionary sodium phenylbutyrate
ATC code A16AX03
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
RTECS  CY9057220
HS Code  29163990
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

Sodium 4-phenylbutyrate price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000808 Sodium phenylbutyrate European Pharmacopoeia (EP) Reference Standard 1716-12-7 5 mg $167 2026-04-30 Buy
Sigma-Aldrich PHR3237 Sodium Phenylbutyrate pharmaceutical secondary standard, certified reference material 1716-12-7 500MG $267 2026-04-30 Buy
Sigma-Aldrich 567616 Sodium 4-Phenylbutyrate 1716-12-7 100mg $91.2 2026-04-30 Buy
Sigma-Aldrich 1614512 Sodium phenylbutyrate United States Pharmacopeia (USP) Reference Standard 1716-12-7 200mg $435 2026-04-30 Buy
Sigma-Aldrich Y0000808 Sodium phenylbutyrate European Pharmacopoeia (EP) Reference Standard 1716-12-7 15 mg $156 2025-07-31 Buy
Product number Packaging Price Buy
Y0000808 5 mg $167 Buy
PHR3237 500MG $267 Buy
567616 100mg $91.2 Buy
1614512 200mg $435 Buy
Y0000808 15 mg $156 Buy

Sodium 4-phenylbutyrate Chemical Properties, Uses, Production

Description

Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.
Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Description

Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins. It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors. Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.

Chemical Properties

White or yellowish-white powder.

Uses

ACE inhibitor, antihypertensive, Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.

Uses

Sodium 4-Phenylbutyrate is a histone-deacetylase inhibitor.

Uses

Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Definition

ChEBI: The organic sodium salt of 4-phenylbutyric acid. A prodrug for phenylacetate, it is used to treat urea cycle disorders.

brand name

Buphenyl (Medicis).

General Description

An antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.

Biological Activity

Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.

Biochem/physiol Actions

Sodium phenylbutyrate is a histone deacetylase inhibitor.

Side effects

Loss of appetite or menstrual changes (delayed/irregular/absent periods) may occur. Serious side effects including: drowsiness/lightheadedness, easy bruising/bleeding, fast/pounding heartbeat, mental/mood changes, tiredness, signs of metabolic imbalance (such as rapid breathing, muscle twitching/spasms).

Synthesis

4-Phenylbutyric acid

1821-12-1

Sodium 4-phenylbutyrate

1716-12-7

0.40 g (2.436 mmol) of 4-phenylbutyric acid was suspended in 30 mL of water, followed by the addition of 0.097 g (2.436 mmol) of sodium hydroxide. After complete dissolution of the acid, the reaction solution was concentrated by rotary evaporator and azeotropically dehydrated twice with toluene. Finally, 0.44 g (96.0% yield) of solid sodium 4-phenylbutyrate was obtained.

Metabolism

Sodium phenylbutyrate (4-PBA sodium salt; Sodium 4-phenylbutyrate) is a prodrug approved by the FDA and indicated as adjunctive therapy in urea cycle disorders. 4-PBA is rapidly metabolized to phenylacetate, an active metabolite, that conjugates with glutamine via acetylation to form phenylacetylglutamine, which is finally excreted by kidneys[2].

storage

Desiccate at -20°C

References

1) Engelhard et al. (1998), Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells; J. Neuro-Oncol., 37 97 2) Appelskog et al. (2004), Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells; Int. J. Oncol., 24 1419.
[2] Salvatore Villani. “Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer.” Pharmaceuticals 16 2 (2023).

Sodium 4-phenylbutyrate synthesis

1821-12-1
1716-12-7
Synthesis of Sodium 4-phenylbutyrate from 4-Phenylbutyric acid

Sodium 4-phenylbutyrate Preparation Products And Raw materials

Raw materials

4-Phenylbutyric acid Water 1-(3-Sulfo-4-phenoxy)-phenyl-3-heptadecyl-4-isopropyl-pyrazoline-5-one Sodium hydroxide

Preparation Products

Sodium 4-phenylbutyrate Suppliers

Global Suppliers ( 347)
Supplier Tel Email Country ProdList Advantage
Jinan Liheng Biotechnology Co., Ltd. 0531-18763987518 18763987518 levi@lihengpharm.com China 1760 58
Rushpharm Co.,Ltd. 025-66042949 15161141411 2244332520@qq.com China 55 58
Eastchem Technology Co., Ltd 18726868929 sales@eastchetech.com China 17 58
Hubei Langbowan Biopharmaceutical Co., Ltd  18086032675 3831791620@qq.com China 1887 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Supplier Advantage
Jinan Liheng Biotechnology Co., Ltd. 58
Rushpharm Co.,Ltd. 58
Eastchem Technology Co., Ltd 58
Hubei Langbowan Biopharmaceutical Co., Ltd  58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
VDM Biochemicals 64

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View Latest Price from Sodium 4-phenylbutyrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium 4-phenylbutyrate pictures 2026-09-02 Sodium 4-phenylbutyrate
1716-12-7
 $1.00-8.00 1KG 99% Henan Fengda Chemical Co., Ltd
Sodium 4-phenylbutyrate pictures 2026-08-20 Sodium 4-phenylbutyrate
1716-12-7
 $54.00-144.00 99.92% 10g TargetMol Chemicals Inc.
Sodium 4-phenylbutyrate pictures 2025-04-04 Sodium 4-phenylbutyrate
1716-12-7
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.

Sodium 4-phenylbutyrate Spectrum

Sodium 4-phenylbutyrate(1716-12-7)1HNMR

1716-12-7 (Sodium 4-phenylbutyrate) Related Search:

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