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Ethyl 4-bromobutyrate

Ethyl 4-bromobutyrate Structure
Ethyl 4-bromobutyrate structure
CAS No.
2969-81-5
Chemical Name:
Ethyl 4-bromobutyrate
Synonyms
Ethyl 4-bromobutanoate;4-BROMOBUTYRIC ACID ETHYL ESTER;4- broMobutanoate;4-Bromobutanoic acid, ethyl ester;4- broMo ethyl;4-bromohexanoate;4-Bromobutylester;Ethyl 4-broMobutyr;BrCH2CH2CH2C(O)OC2H5;Ethl 4-broMobutyrate
CBNumber:
CB5216846
Molecular Formula:
C6H11BrO2
Molecular Weight:
195.05
MDL Number:
MFCD00000259
MOL File:
2969-81-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:10:49
Product description Number Pack Size Price
Ethyl 4-bromobutyrate 95% 167118 50g $64.8
Ethyl 4-bromobutyrate 95% 167118 250g $284
Ethyl 4-Bromobutyrate >97.0%(GC) B0999 25g $24
Ethyl 4-Bromobutyrate >97.0%(GC) B0999 100g $63
Ethyl 4-bromobutanoate 134599 100.00g $32
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Ethyl 4-bromobutyrate Properties

Melting point 98-100 °C
Boiling point 80-82 °C/10 mmHg (lit.)
Density 1.363 g/mL at 25 °C (lit.)
refractive index n20/D 1.456(lit.)
Flash point 195 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
form Liquid
color Clear colorless to yellow
Specific Gravity 1.363
Water Solubility immiscible
BRN 1749700
InChI 1S/C6H11BrO2/c1-2-9-6(8)4-3-5-7/h2-5H2,1H3
InChIKey XBPOBCXHALHJFP-UHFFFAOYSA-N
SMILES CCOC(=O)CCCBr
CAS DataBase Reference 2969-81-5(CAS DataBase Reference)
FDA UNII EZ8TY5JSD5
NIST Chemistry Reference Ethyl 4-bromobutyrate(2969-81-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38-22
Safety Statements  26-36-37/39
WGK Germany  3
HS Code  2915900090
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
2
2 0

Ethyl 4-bromobutyrate price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 167118 Ethyl 4-bromobutyrate 95% 2969-81-5 50g $64.8 2026-04-30 Buy
Sigma-Aldrich 167118 Ethyl 4-bromobutyrate 95% 2969-81-5 250g $284 2026-04-30 Buy
TCI Chemical B0999 Ethyl 4-Bromobutyrate >97.0%(GC) 2969-81-5 25g $24 2026-04-30 Buy
TCI Chemical B0999 Ethyl 4-Bromobutyrate >97.0%(GC) 2969-81-5 100g $63 2026-04-30 Buy
Matrix Scientific 134599 Ethyl 4-bromobutanoate 2969-81-5 100.00g $32 2026-05-18 Buy
Product number Packaging Price Buy
167118 50g $64.8 Buy
167118 250g $284 Buy
B0999 25g $24 Buy
B0999 100g $63 Buy
134599 100.00g $32 Buy

Ethyl 4-bromobutyrate Chemical Properties,Uses,Production

Description

Ethyl 4-bromobutyrate is a colourless volatile liquid organic or biological reagent. It is used in organic synthesis to prepare 4-bromobutyl ester, 4-bromobutyl amide and 4-bromobutyl ether. It is also used in the synthesis of poly(2,6-dimethyl-1,4-epoxyphenyl ether) and isotopic thieno[2,3-b]azepin-4-one thieno[2,3-b]-azepin-4-one with antitumour activity. In the biological field, it has been used in enzyme-linked immunosorbent assays for zilpaterol.

Chemical Properties

clear colorless to yellow liquid

Uses

A versatile building block and synthesis reagent

Uses

Ethyl 4-bromobutyrate is used as a building block for the preparation of firefly luciferase inhibitor-conjucated peptide derivatives. It finds application in the synthesis of poly(2,6,-dimethyl-1,4-phehylene oxide) and thieno(2,3-b)-azepin-4-ones.

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 2264, 1991 DOI: 10.1021/jo00006a061

Hazard

Strongly irritating to skin and eyes

Synthesis

4-Bromobutyric acid

2623-87-2

Ethyl 4-bromobutyrate

2969-81-5

Part A: Synthesis of ethyl 4-bromobutyrate To a solution of 4-bromobutyric acid (3 g, 18 mmol) in ethanol (30 mL) was added 5 mL of a dioxane solution of 4N HCl. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the volatile components were removed under vacuum. The concentrated residue was dissolved in 150 mL of dichloromethane. The organic phase was washed sequentially with saturated aqueous NaHCO3 (1 x 150 mL) and brine (1 x 150 mL), dried over anhydrous MgSO4, filtered, and the filtrate was concentrated under reduced pressure. The concentrated residue was dried under vacuum to give 3 g (85.5% yield) of ethyl 4-bromobutyrate as a yellow oil.1H NMR (300 MHz, CDCl3): δ1.22 (t, 3H, J = 7.15 Hz), 2.13 (m, 2H, J = 6.80 Hz), 2.45 (t, 2H, J = 7.15 Hz), 3.43 (t , 2H, J = 6.44Hz), 4.10 (q, 2H, J = 7.25Hz).

References

[1] Patent: US5753660, 1998, A

Ethyl 4-bromobutyrate synthesis

96-48-0
64-17-5
2969-81-5
Synthesis of Ethyl 4-bromobutyrate from Gamma Butyrolactone and Ethanol

Ethyl 4-bromobutyrate Preparation Products And Raw materials

Raw materials

4-Bromobutyric acid Dichloromethane 1,4-Dioxane Ethanol Hydrochloric acid

Preparation Products

4-Bromo-1,1-bis-(3-methyl-thiophen-2-yl)-butan-1-ol ,97% 1-(4-Morpholinobutyl)hydrazine 4-BROMO-1,1-BIS(3-METHYL-2-THIENYL)-1-BUTENE Ethyl caprate 1-(4-(Pyrrolidin-1-yl)butyl)hydrazine
Diethyl succinosuccinate Ethyl 4-hydroxybutanoate S-(3-Carboxypropyl)-L-cysteine Ethyl 4-(bromomethyl)benzoate Ethyl 4-Nitrobutanoate
ethyl (Z)-oct-4-enoate Gamma Butyrolactone 5-Bromo-2-methyl-2-pentanol Butanoic acid, 4-(3-formylphenoxy)-, ethyl ester ETHYL 5-(2-CHLOROPHENYL)-5-OXOVALERATE
Ethyl 4-(4-methylphenyl)sulfanylbutanoate

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Ethyl 4-bromobutyrate Suppliers

Global( 550)Suppliers
Supplier Tel Email Country ProdList Advantage
Lewoo Pharmatech(Shanghai)Co.,Ltd
+86-15800805830 miao@lewoopharma.com.cn China 184 58
Zouping mingyuan import & export trading co., ltd
+86-0543-2240078 +8618364991597 myzhao793@163.com China 981 58
Nanjing Hike Biological Technology CO. Ltd. 		+86-025-52110956; +8613814852963 sales@njhkchem.com China 8 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5233 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Supplier Advantage
Lewoo Pharmatech(Shanghai)Co.,Ltd
58
Zouping mingyuan import & export trading co., ltd
58
Nanjing Hike Biological Technology CO. Ltd. 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

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View Lastest Price from Ethyl 4-bromobutyrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 4-bromobutyrate pictures 2026-01-26 Ethyl 4-bromobutyrate
2969-81-5
 US $0.00 / KG 25KG ≥99.0% 5tons Nanjing Liskon Biological Technology Co., Ltd
Ethyl 4-bromobutyrate pictures 2025-12-01 Ethyl 4-bromobutyrate
2969-81-5
 US $0.00-0.00 / KG 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Ethyl 4-bromobutyrate pictures 2025-09-25 Ethyl 4-bromobutyrate
2969-81-5
 US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

Ethyl 4-bromobutyrate Spectrum

Ethyl 4-bromobutyrate(2969-81-5)MSEthyl 4-bromobutyrate(2969-81-5)1HNMREthyl 4-bromobutyrate(2969-81-5)13CNMREthyl 4-bromobutyrate(2969-81-5)IR1Ethyl 4-bromobutyrate(2969-81-5)IR2Ethyl 4-bromobutyrate(2969-81-5)Raman

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BrCH2CH2CH2C(O)OC2H5 Butanoic acid, 4-bromo-, ethyl ester Ethyl gamma-bromobutyrate ETHYL 4-BROMO-N-BUTYRATE ETHYL 4-BROMOBUTYRATE ETHYL GAMMA-BROMO-N-BUTYRATE ETHYL G-BROMOBUTYRATE GAMMA-BROMOBUTYRIC ACID ETHYL ESTER Ethyl 4-bromibutyrate Ethyl 4-bromobutanoic acid 4-BROMO-N-BUTYRIC ACID ETHYL ESTER 1-Bromo-3-(carboethoxy)propane 3-(Ethoxycarbonyl)propyl bromide Butyric acid, 4-bromo-, ethyl ester 4-Bromobutanoic acid ethyl 4-Bromobutyric acid ethyl Ethyl 4-bromobutyrate ,98% 4-broMo ethyl butyrate Ethl 4-broMobutyrate Ethyl 4-broMobutyrate, 95% 100ML Ethyl 4-bromobutyrate,95% Ethyl 4-broMobutyr 4- broMo ethyl Ethyl 4-broMobutyrate 95% 4- broMobutanoate 4 - broMine ethyl butyrate Ethyl 4-bromobutanoate 98% 4-bromohexanoate Ethyl 4-bromobutyrate, 98%, for synthesis Ethyl 4-Bromobutyrate > Ethyl 4-Bromobutyrate, ≥ 97.0% 4-Bromobutylester 4-Bromobutanoic acid, ethyl ester Ethyl 4-bromobutanoate 4-BROMOBUTYRIC ACID ETHYL ESTER 4-Bromobutyrate ethyl 2969-81-5 BrCH23COOC2H5 BrCH23CO2CH2CH3 HALOGEN Carbonyl Compounds C6 to C7 Building Blocks Esters Organic Building Blocks Pyridines Acids & Esters Bromine Compounds C6 to C7 Carbonyl Compounds Esters bc0001